発表論文
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英文（原著、総説及び著書）
1. Tsunematsu, T., Takihara, Y., Ishimuara, N., Pagano, M., TAkata, T., Kudo,
Y. (2013) Aurora-A controls pre-replicative complex foramtion and DNA replication
by promoting the stabilization of geminin in mitosis.
Nature Commun., in press.
2. Hirata, O., Okada, S., Tsumura, M., Kagawa, R., Miki, M., Kawaguchi, H.,
Nakamura, K., Boisson-Dupuis, S., Casanova, J.-L., Takihara, Y., Kobayashi,
M. (2013) Heterozygosity for the Y701C STAT1 mutation in a multiplex kindred
with multifocal osteomyelitis.
Ann. Hematol., in press.
3. Yasunaga, S., Ohtubo, M., Ohno, Y., Tanaka-Okamoto, M., Ishizaki, H.,
Shirai, M., Mihara, K., Brock, W.H., Miyoshi, J., Takihara, Y. (2013) Scmh1
has E3 ubiquitin ligase activity for Geminin and hitone H2A and regulates
Geminin stability directly or indirectly via transcriptional repression
of Hoxa9 and Hoxb4.
Mol. Cell. Biol. 33, 644-660..
4. Ohno, Y., Yasunaga, S., Janmohamed, S., Ohtsubo, M., Mihara, K., Iscove,
N., Takihara, Y. (2013) Hoxa9 transduction induces mouse hematopoietic
stem and progenitor cell activity through direct down-regulation of Geminin.
PLoS ONE 8(1):e53161.doi:10.1371/journal.pone.0053161.
5. Endo, K., Mihara, K., Oiwa, H., Yoshida, T., Mino, T., Sasaki, N., Takihara,
Y. (2013) Lung involvement at initial presentation in blastic plasmacytoid
dendritic cell neoplasm lacking cutaneous lesion.
Ann. Hematol. 2, 269-270.
6. Yoshida, T., Mihara, K., Sugihara, S., Arihiro, K., Mino, T., Sasaki, N.,
Takihara, Y. (2013) Splenectomy followed by administration of rituximab
is useful to treat a patient with hairy cell leukemia-variant.
Ann. Hematol. 92, 711-713..
7. Bhattacharyya, J., Mihara, K., Morimoto, K., Takihara, Y., Kimura, A.,
Hide, M. (2012) Elevated Interleukin-18 secretion from monoclonal IgM+ Bells in a patient with Schnitzler syndrome,
J. Am. Acad. Dermatol.67, e118-e120.
8. Tsumura, M., Okada, S., Sakai, H., Yasunaga, S,. Ohtsubo, M., Murata,
T., Obata, H., Yasumi, T., Kong, X., Abhyankar, A., Heike, T., Nakahata,
T., Nishikomori, R., Al-Muhsen, S., Boisson-Dupuis, S., Casanova, J.-L.,
AlSherhri, M., ElGhazali, G., Takihara, Y., Kobayashi, M. (2012) Dominant-negative
STAT1 mutations in the SH2 domain predispose to mycobacterial diseases.
Hum. Mutat. 33, 1377-1387.
9. Bhattacharyya, J., Mihara, K., Kitanaka, A., Yanagihara, K., Kudo, T.,
Takei, Y., Kuroda, T., Kimura, A., Takihara, Y. (2012) T-cell immunotherapy
with a chimeric receptor against CD38 is effective in eradicating refractory
B-lymphoma cells overexpressing survivin induced by BMI-1.
Blood Cancer J. 2, e75.
10. Prichaerts, P., Niessen, H., Mou-chel-Vielh, E., Dahlmans, V., Geijselaers,
C., Adriaens, M., Spaapen, F., Takihara, Y., Rapp, U., Peronnet, F., Voncken,
J.W. (2012) MK3 controls Polycomb-taret gene expression via negative feedback
on ERK.
Epigenetics Chromatin 5, 12.
11. Ozaki, Y., Matsui, H., Asou, H., Nagamachi, A., Aki, D., Honda, H., Yasunaga,
S., Takihara, Y., Yamamoto, T., Izumi, S., Ohsugi, M., Inaba, T. (2012)
Poly-ADP ribosylation of Miki by tankylase-1 promotes cntrosome maturation.
Mol. Cell 47, 694-706.
12. Bhattacharyya, J., Mihara, K., Ohtusbo, M., Yasunaga, S., Hoshi, M.,
Takihara, Y., Kimura, A. (2012) Overexpression of BMI-1 correlates with
drug resistance in B-cell lymphomas through the stabilization of survivin
expression.
Cancer Scie. 103, 34-41
13. Bhattacharyya, J., Mihara, K., Takihara, Y., Kimura, A. (2012) Successful treatment of
IgM-monoclonal gammopathy of undetermined significance associated with
cryoglobulinemia and cold agglutinin disease with immunochemotherapy with
rituximab, fludarabine, and cyclophosphamide.
Ann. Hematol. 91, 797-799.
14. Mihara, K., Bhattacharyya, J., Kitanaka, A., Yanagihara, K., Kubo, T., Takei, Y., Sakai, A., Asaoku, H., Takihara, Y., Kimura, A. (2012) T-cell
immunotherapy with a chimeric receptor against CD38 is effective in eliminating
myeloma cells.
Leukemia 26, 365-367.
15. Karakawa, S., Okada, S., Tsumura, M., Mizoguchi, Y., Ohno, N., Yasunaga,
S., Ohtsubo, M., Kawai T. Nishikomori, R., Sakaguchi, T., Takihara, Y., Kobayashi, M. (2011) Decreased expression in nuclear factor-kappaB essential
modulator due to a novel splice-site mutation caused X-linked ectodermal
dsplasia with immunodeficiency.
J. Clin. Immunol. 31, 762-772.
16. Takihara, Y. (2011) Role for Geminin in sustaining the activity of hematopoietic
stem cells.
Cell Cycll 10, 561-562.
17. Ohno, Y., Yasunaga, S., Ohtsubo, M., Mori, S., Tsumura, M., Okada, S.,
Ohta, T., Ohtani, K., Kobayashi, M., Takihara, Y. (2010) Hoxb4 transduction
down-regulates Geminin protein, providing hematopoietic stem and progenitor
cells with growth potential.
Proc. Natl. Acad. Sci. USA 107, 21529-21534.
18. Mihara, K., Yanagihara, K., Takigahira, M., Kitanaka, A., Imai, C., Bhattachayya,
J., Kubo, T., Takei, Y., Yasunaga, S., Takihara, Y., Kimura, A. (2010)
Synergistic and persistent effect of T-cell immunotherapy with anti-CD19
or anti-CD38 chimeric receptor in conjunction with rituximab on B-cell
non-Hodgkin's lymphoma.
British J. Haematol. 151, 37-46.
19. Shirao, K., Okada, S., Tajima, G., Tsumura, M., Hara, K., Yasunaga, S.,
Ohtsubo, M., Hata, I., Sakura, N., Shigematsu, Y., Takihara, Y., Kobayashi,
M. (2010) Molecular pathogenesis of a novel mutation, G108D, in short-chain
acyl-CoA dehydrogenase identified in subjects with short-chain acyl-CoA
dehydrogenase deficiency.
Human Genet. 127, 619-628.
20. Okada, S., Konishi, N., Tsumura, M., Shirao, K., Yasunaga, S., Sakai,
H., Nishikomori, R., Takihara, Y., Kobayashi M. (2009) Cardiac infiltration
in early-onset Sarcoidosis associated with a novel heterozygous mutation,
G418N, in CARD15.
Rheumatology 48, 706-707.
21. Mihara, K., Yanagihara, K., Takigahira, M., Imai, C., Kitanaka, A., Takihara,
Y., Kimura, A. (2009) Activated T Cell-mediated immunotherapy with a chimeric
receptor against CD38 in B-cell non-Hodgkin lymphoma.
J. Immunother. 32, 737-743.
22. Ishikawa, N., Okada, S., Miki, M., Shirao, K., Kihara, H., Tsumura, M.,
Nakamura, K., Kawaguchi, H., Ohtsubo, M., Yasunaga, S., Matsubara, K.,
Sako, M., Hara, J,. Shinohara, M., Kojima, S., Sato, T., Takihara, Y.,
Kobayashi, M. (2008) Neurodevelopmental abnormalities associated with severe
congenital neutropenia due to the R86X mutation in the HAX1 gene.
J. Med. Genet. 45, 802-807.
23. Bhattacharyya, J., Mihara, K., Yasunaga, S., Tanaka, H., Hoshi, M., Takihara,
Y., Kimura, A. (2008) BMI-1 expression is enhanced through transcriptional
and post-transcriptional regulation during the progression of chronic myeloid
leukemia.
Ann. Hematol. 88, 333-340.
24. Ohtsubo, M., Yasunaga, S., Ohno, Y., Tsumura, M., Okada, S., Ishikawa,
N., Shirao, K., Kikuchi, A., Nishitani, H., Kobayashi, M., Takihara, Y.
(2008) Polycomb-group complex 1 acts as an E3 ubiquitin ligase for Geminin
to sustain hematopoietic stem cell activity.
Proc. Natl. Acad. Sci. USA 105, 10396-10401, cited in This Week in PNAS.
25. Mihara, K., Kido, M., Nakaju, N., Fukumoto, S., Matsumoto, R., Takihara,
Y., Kimura, A. (2007) Exacerbation of acute leukemia bearing isolated i(17q)
along with proliferation of blasts with high BMI-1 expression.
Rinsho Ketsueki 48, 659-63.
26. Takihara, Y. (2008) Role of Polycomb-group genes in normal and malignant
stem cells.
Int. J. Hematol. 87, 25-34. (Review).
27. Mihara, K., Takihara, Y., Kimura, A. (2007) Genetic and epigenetic alterations
in myelodysplastic syndrome
Cytogenet. Cell Genet. 118, 297-303. (Review).
28. Chowdhury, M., Mihara, K., Yasunaga, S., Ohtaki, M., Takihara, Y., Kimura,
A. (2007) Expression of Polycomb-group (PcG) protein BMI-1 predicts prognosis
in patients with acute leukemia.
Leukemia 21, 1116-1122.
29. Ishikawa, N., Okada, S., Sato, T., Yasunaga, S., Ohtsubo, M., Takihara,
Y., Kobayashi, M. (2007) A novel mutation (Gln433Glu) in exon 12 combined
with the G insertion in exon 13 causes severe factor XI deficiency in Japanese
patients.
Blood Coagulation and Fibrinolysis 18: 519-523.
30. Okada, S., Ishikawa, N., Shirao, K., Kawaguchi, H., Tsumura, M., Ohno,
Y., Yasunaga, S., Ohtsubo, M., Takihara, Y., Kobayashi, M. (2007) The novel
IFNGR1 mutation 774del4 produces a truncated form of interferon-gamma receptor
1 and has a dominant-negative effect on interferon-gamma signal transduction.
J. Med. Genet. 44: 485-491.
31. Mihara, K., Chowdhury, M., Nakaju, N., Hidani, S., Ihara, A., Hyodo,
H., Yasunaga, S., Takihara, Y., Kimura, A. (2006) Bmi-1 is useful as a
novel molecular marker for predicting progression of myelodysplastic syndrome
and patient prognosis.
Blood 107, 305-308.
32. Fujimura, Y.I., Isono, K.I., Vidal, M., Endoh, M., Kajita, H., Mizutani-Koseki,
Y., Takihara, Y., van Lohuizen, M., Otte, A., Jenuwein, T., Deschamps,
J., Koseki, H. (2006) Distinct role of Polycomb group gene products in
transcriptionally repressed and active domains of Hoxb8.
Development 133, 2371-2381.
33. Isono, K., Fujimura, Y., Shinga, J., Yamaki, M., O-Wang, J., Takihara,
Y., Murahashi, Y., Takada, Y., Mizutani-Koseki, Y., Koseki, H. (2005) Mammalian
Polyhomeotic homologues Phc2 and Phc1 act in synergy to mediate Polycomb-repression
of Hox genes.
Mol. Cell Biol. 25, 6694-6706.
34. Luo, L., Yang, X., Takihara, Y., Knoetgen, H., Kessel, M. (2004) The cell
cycle-regulator Geminin inhibits Hox function through direct and Polycomb-mediated
interactions.
Nature 427, 749-753.
35. Luo, P., Tresini, M., Cristofalo, V., Chen, X., Saulewicz, A., Gray, M.D.,
Banker, D.E., Klingelhutz, A.L., Ohtsubo, M., Takihara, Y., Norwood, T.H.
(2004) Immortalization in a normal foreskin fibroblast culture following
transduction of Cyclin A2 or Cdk1 gene in retroviral vectors.
Exp. Cell Res. 294, 406-419.
36. Kim, J. Y., Sawada, A., Tokimasa, S., Ohta, H., Endo, H., Hara, J., Takihara,
Y. (2004) Defective long-term repopulating ability of hematopoietic stem
cells lacking Polycomb-group gene rae28.
Eur. J. Haematol. 73, 75-84.
37. Hashii, Y., Kim, J.Y., Sawada, A., Tokimasa, S., Hiroyuki, F., Ohta, H.,
Makiko, K., Takihara, Y., Ozono, K., Hara, J. (2004) A novel partner gene
CIP29 containing a SAP domain with MLL identified in infantile myelomonocytic
leukemia.
Leukemia 18, 1546-1548.
38. Miyagishima, H., Isono, K., Fujimura, Y., Iyo, M., Takihara ,Y., Masumoto.
H., Vidal, M., Koseki, H. (2003) Dissociation of mammalian Polycomb-group
proteins, Ring1B and Rae28/Ph1, from the chromatin correlates with configuration
changes of the chromatin in mitotic and meiotic prophase.
Histochem. Cell Biol. 120, 111-119.
39. Sawada, A., Takihara, Y., Kim, J. Y., Matsuda, Y., Tokimasa, S., Fujisaki,
H., Kubota, K., Endo, H., Onodera, T., Ohta, H., Ozono, K., Hara, J. (2003)
A congenital mutation of the novel gene LRRC8 causes agammaglobulinemia
in humans.
J. Clin. Invest. 112,1707-1713.
40. de Graaff, W., Tomotsune, D., Oosterveen, T., Takihara, Y., Koseki, H.,
Deschamps, J. (2003) Randomly inserted and targeted Hox/reporter fusions
transcriptionally silenced in Polycomb mutants.
Proc. Natl. Acad. Sci. USA 100,13362-13367.
41. Koga, H., Kaji, Y., Nishii, K., Shirai, M., Tomotsune, D., Osugi, T.,
Sawada, A., Kim, J. Y., Hara, J., Miwa, T., Yamauchi-Takihara, K., Shibata,
Y., Takihara, Y. (2002) Overexpression of the Polycomb-group gene rae28
in cardiomyocytes does not complement abnormal cardiac morphogenesis in
rae28-deficient mice, but causes dilated cardiomyopathy.
Lab. Invest. 82, 375-385, cited in cover.
42. Ohta, H., Sawada, A., Kim, J. Y., Tokimasa, S., Nishiguchi, S., Humphries,
R. K., Hara, J., Takihara, Y. (2002) The Polycomb-group gene rae28 is required
for sustaining activity of hematopoietic stem cells.
J. Exp. Med. 195, 759-770.
43. Shirai, M., Osugi, T., Koga, H., Kaji, Y., Takimoto, E., Komuro, I., Hara,
J., Miwa, T., Yamauchi-Takihara, K., Takihara, Y. (2002) The Polycomb-group
gene rae28 sustains Nkx2.5/Csx expression and is essential for cardiac
morphogenesis.
J. Clin. Invest. 110, 177-184, cited in cover.
44. Suzuki, M., Mizutani-Koseki, Y., Fujimura, Y., Miyagishima, H., Kaneko,
T., Takada, Y., Akasaka , T., Tanzawa, H., Takihara, Y., Nakano, M., Masumoto,
H., Vidal, M., Isono, K., Koseki, H. (2002) Involvement of the Polycomb-group
gene Ring1B in the specification of the anterior-posterior axis of vertebrates.
Development 129, 4171-4183.
邦文（総説及び著書）
1.瀧原義宏、安永晋一郎、大野芳典、大坪素秋（2012）幹細胞における細胞周期制御 特集：がん幹細胞研究の新たな展開 血液フロンティア（医薬ジャーナル社） 22, 33-43.
2.瀧原義宏 （2011)造血幹細胞の守護神Geminin 原医研ニュース 2, 6-7.
3.瀧原義宏 （2010）「細胞周期のフロンティア」細胞分化と増殖制御-造血幹細胞の活性支持におけるポリコーム複合体の機能 蛋白質 核酸 酵素（共立出版） pp. 230-235.
4.瀧原義宏 （2009）Gemininの制御と機能の多面性
特集「細胞周期研究の新たなステージ」
細胞工学（秀潤社）128, 29-33.
5.瀧原義宏 （2009）造血幹細胞の維持へのユビキチンープロテオソーム系の関与
生体の科学（医学書院）60, 563-569.
6.瀧原義宏 （2007）ポリコーム遺伝子群
造血器腫瘍アトラス（日本医事新報社）44-48.
7.瀧原義宏 （2007）がん幹細胞の活性を支持するポリコーム遺伝子群の役割
Biotherapy（癌と科学療法社）21, 75-82.
8.瀧原義宏 （2007）白血病幹細胞研究の新展開
Front Wave in Hematology（アトリスク）20, 4-7.
9.三原圭一朗、木戸みき、中十奈苗、福本祥子、松本涼子、瀧原義宏、木村昭郎（2007）BMI-1高発現芽球の増加に伴い、臨床経過の増悪をきたしたisolated
I(17q)染色体異常を有する急性白血病
臨床血液学会雑誌 48, 659-663.
10.瀧原義宏 （2006）「再生医学最前線」ポリコーム遺伝子群の分子機能と幹細胞制御：幹細胞を支持する分子基盤
医学のあゆみ（医歯薬出版） 217, 557-562.
11.瀧原義宏 （2006）幹細胞の活性を支持するポリコーム遺伝子群
放射線科学（実業広報社）49, 353-360.
12.瀧原義宏（2005）I. 幹細胞 - 2. 造血幹細胞の自己複製機構
Annual Review 血液 2005 (中外医学社) pp.11-24.
13.瀧原義宏（2005）再生医療教科書シリーズ（コロナ社）第3巻「再生医療のための分子生物学」18. 幹細胞のシグナル伝達 Hox/Polycomb
pp. 228-238.
14.瀧原義宏（2005）ポリコーム遺伝子群と造血幹細胞
医学のあゆみ（医歯薬出版）別冊「血液疾患 - state of arts Ver.3」pp. 52-54.
15.瀧原義宏 （2005）白血病は何時から治る病になったか？ ?造血幹細胞を用いた骨髄再生療法の現状と将来?
原子力システムニュース 16, 5-16.
16.瀧原義宏（2004）ポリコーム遺伝子群の機能
細胞工学（秀潤社）23, 74-80.
17.瀧原義宏（2004）自己複製能をもつ造血幹細胞を維持するためにはbmi1が必要である
分子細胞治療（先端医学社）3, 104-105.
18.瀧原義宏（2004）「News & Hot Paper Digest」細胞特性化とDNA複製制御の接点
実験医学（羊土社）22, 953.
19.瀧原義宏（2004）ポリコーム遺伝子群による造血制御
臨床血液 45, 363-371.
20.瀧原義宏、金 智裕（2003）ポリコーム遺伝子群と造血幹細胞
血液・腫瘍科（科学評論社）46,452-459.