主要発表論文

1.         ウイルス病 Viral diseases

1)      ウイルス性神経壊死症 Viral nervous necrosis (VNN)

2)      その他のウイルス病 Other viral diseases

2.         細菌病 Bacterial diseases

3.         バクテリオファージ療法 Bacteriophage therapy

4.         総説・解説 Reviews

 

1. ウイルス病 Viral diseases

1)      ウイルス性神経壊死症 Viral nervous necrosis (VNN)

Okinaka, Y. and T. Nakai (2008): Comparisons among the complete genomes of four betanodavirus genotypes. Dis. Aquat. Org. 80, 113-121

Ito, Y., Y. Okinaka, K. Mori, T. Sugaya, T. Nishioka, M. Oka and T. Nakai (2008): The variable region of RNA2 is sufficient to determine host specificity in betanodaviruses. Dis. Aquat. Org. 79, 199-205

Sakamoto, T., Y. Okinaka, K. Mori, T. Sugaya, T. Nishioka, H. Yamashita, M. Oka and T. Nakai (2008): Phylogenetic analysis of betanodavirus RNA2 identified from wild marine fish in oceanic regions. Fish Pathol. 43, 19-27

Hata, N., Y. Okinaka, T. Sakamoto, T. Iwamoto and T. Nakai (2007): Upper temperature limits for the multiplication of betanodaviruses. Fish Pathol. 42, 225-228

Furusawa, R., Y. Okinaka, K. Uematsu and T. Nakai (2007): Screening of freshwater fish species for their susceptibility to a betanodavirus. Dis. Aquat. Org. 77, 119-125

Furusawa, R., Y. Okinaka and T. Nakai (2006): Betanodavirus infection in the freshwater model fish medaka (Oryzias latipes). J. Gen. Virol. 87, 2333-2339

Iwamoto, T., K. Mise, A. Takeda, Y. Okinaka, K. Mori, M. Arimoto, T. Okuno and T. Nakai (2005): Characterization of Striped jack nervous necrosis virus subgenomic RNA3 and biological activities of its encoded protein B2. J. Gen. Virol., 86, 2807-2816

Pakingking R. Jr., K. Mori, T. Sugaya, M. Oka, Y. Okinaka and T. Nakai (2005): Aquabirnavirus-induced protection of marine fish against piscine nodavirus infection. Fish Pathol., 40, 125-131

Yamashita H., Y. Fujita, H. Kawakami and T. Nakai (2005): The Efficacy of Inactivated Virus Vaccine against Viral Nervous Necrosis (VNN). Fish Pathol., 40, 15-21

Gomez D K, J. Sato, K. Mushiake, T. Isshiki, Y. Okinaka and T. Nakai (2004): PCR-based detection of betanodaviruses from asymptomatic cultured and wild marine fish. J. Fish Dis., 27, 603-608

Banu G. R. and T. Nakai (2004) Inoculation of BALB/c Mice with Fish-pathogenic Nodaviruses. J. Comp. Pathol. 130, 202-204

Iwamoto T., Y. Okinaka, K. Mise, K. Mori, M. Arimoto, T. Okuno and T. Nakai (2004): Identification of host-specificity determinants in betanodaviruses using reassortants between striped jack nervous necrosis virus and sevenband grouper nervous necrosis virus. J. Virol. 78, 1256-1262

Mori K., Mangyoku T., Iwamoto T., Arimoto M., Tanaka S. and Nakai T. (2003): Serological relationships among genotypic variants of betanodavirus. Dis. Aquat. Org. 57, 19-26

Tanaka S., I. Kuriyama, T. Nakai and T. Miyazaki (2003): Susceptibility of cultured juveniles of several marine fish to the sevenband grouper nervous necrosis virus. J. Fish Dis. 26, 109-115

Ikenaga T., Y. Tatecho, T. Nakai and K. Uematsu (2002): Betanodavirus as a novel transneuronal tracer for fish. Neurosci. Lett. 331, 55-59

Yuasa K., I. Koesharyani, D. Roza, K. Mori, M. Katata and T. Nakai (2002): Immune response of humpback grouper Cromileptes altivelis injected with the recombinant coat protein of betanodvirus. J. Fish Dis., 25, 53-56.

Iwamoto T., K. Mise, K. Mori, M. Arimoto, T. Nakai and T. Okuno (2001): Establishment of an Infectious RNA Transcription System for Striped Jack Nervous Necrosis Virus, the Type Species of the Betanodavirus. J. Gen. Virol. 82:2653-2662

Lin L., J. He, K. Mori, T. Nishioka, J. L. Wu, S. Weng, K. Mushiake, M. Arimoto and T.   Nakai (2001): Mass mortalities associated with viral nervous necrosis in hatchery-reared groupers in the People’s Republic of China. Fish Pathol. 36: 186-188

P.A. Curtis, M. Drawbridge, T. Iwamoto, T. Nakai, R.P. Hedrick and A.P. Gendron (2001): Nodavirus infection of juvenile white seabass cultured in Southern California: First record of viral nervous necrosis (VNN) in North America. J. Fish Dis. 24:263-271

Iwamoto T., K. Mori, M. Arimoto, and T. Nakai (2001) A combined cell-culture and RT-PCR method for rapid detection of piscine nodaviruses. J. Fish Dis. 24:231-236

Iwamoto T., T. Nakai, K. Mori, M. Arimoto, K. Mise and I. Furusawa (2001): Transfection of striped jack nervous necrosis virus (SJNNV) RNA into fish cells. J. Fish    Dis. 24:185-188

Tanaka S., K. Mori, M. Arimoto, T. Iwamoto and T. Nakai (2001): Protective immunity of sevenband grouper Epinephelus septemfasciatus against experimental viral nervous necrosis (VNN). J. Fish Dis. 24, 15-22.

Iwamoto T., T. Nakai, K. Mori, M. Arimoto, and I. Furusawa (2000): Cloning of the fish cell line SSN-1 for piscine nodaviruses. Dis. Aquat. Org. 43:81-89

Iwamoto T., K. Mori, M. Arimoto and T. Nakai (1999): High permissivity of the fish cell line SSN-1 for piscine nodaviruses. Dis. Aquat. Org., 39:37-47.

Totland G., S. Grotmol, Y. MORITA, T. Nishioka and T. Nakai (1999): Pathogenicity of nodavirus strains from striped jack Pseudocaranx dentex and Atlantic halibut Hippoglossus hippoglossus, studied by waterborne challenge of yolk-sac larvae of both teleost species.  Dis. Aquat. Org., 38:167-175.

Tanaka, S., H. Aoki, and T. Nakai (1998): Pathogenicity of the nodavirus detected from diseased sevenband grouper Epinephelus septemfasciatus. Fish Pathol., 33, 31-36.

Munday, B.L. and T. Nakai (1997): Special topic review: nodaviruses as pathogens in larval and juvenile marine finfish.  World J. Microbiol. Biotechnol., 13, 375-381.

Nishizawa, T., M. Furuhashi, T. Nagai, T. Nakai, and K. Muroga (1997): Genomic classification of fish nodaviruses by molecular phylogenetic analysis of the coat protein gene.  Appl. Environ. Mirobiol., 63, 1633-1636.

Nguyen H.D., K. Mushiake, T. Nakai, and K. Muroga (1997): Tissue distribution of striped jack nervous necrosis virus (SJNNV) in adult striped jack.  Dis. Aquat. Org., 28, 87-91.

Fukuda Y., H.D. Nguyen, M. Furuhashi, and T. Nakai (1996): Mass mortality of cultured sevenband grouper, Epinephelus septemfasciatus, associated with viral nervous necrosis. Fish Pathol., 31, 165-170.

Nguyen H.D., T. Nakai, and K. Muroga (1996): Progression of striped jack nervous necrosis virus (SJNNV) infection in naturally and experimentally infected striped jack Pseudocaranx dentex larvae.  Dis. Aquat. Org., 24, 99-105.

Nishizawa T., K. Mori, M. Furuhashi, T. Nakai, I. Furusawa, and K. Muroga (1995): Comparison of the coat protein genes of five fish nodaviruses, the causative agents of viral nervous necrosis in marine fish.  J. Gen. Virol., 76, 1563-1569.

Nishizawa T., M. Kise, T. Nakai, and K. Muroga (1995): Neutralizing monoclonal antibodies to striped jack nervous necrosis virus (SJNNV).  Fish Pathol., 30, 111-114

Munday B.L., T. Nakai, and H.D. Nguyen (1994): Antigenic relationship of the picorna-like virus of larval barramundi, Lates calcarifer Bloch to the nodavirus of larval striped jack, Pseudocaranx dentex (Bloch & Schneider).  Aust. Vet. J., 71, 384

Nguyen H.D., T. Mekuchi, K. Imura, T. Nakai, T. Nishizawa, and K. Muroga (1994): Occurrence of viral nervous necrosis (VNN) in hatchery-reared juvenile Japanese flounder Paralichthys olivaceus.  Fisheries Science 60, 551-554

Nakai T., H.D. Nguyen, T. Nishizawa, K. Muroga, M. Arimoto, K. Ootsuki (1994): Occurrence of viral nervous necrosis in kelp grouper and tiger puffer. Fish Pathol. 29, 211-212. (in Japanese)

Mushiake k., T. Nishizawa, T. Nakai, I. Furusawa, and K. Muroga (1994): Control of VNN in striped jack: Selection of spawners based on the detection of SJNNV gene by polymerase chain reaction (PCR).  Fish Pathol. 29(3), 177-182

Nishizawa T., K. Mori, T. Nakai, I. Furusawa, and K. Muroga (1994): Polymerase chain reaction (PCR) amplification of RNA of striped jack nervous necrosis (SJNNV).  Dis.Aquat. Org. 18, 103-107.

Mushiake K., T. Nakai, K. Muroga, S. Sekiya, and I. Furusawa (1993): Viral nervous necrosis (VNN) of striped jack : Effects of plasma antibody level of spawners and spawning conditions on the occurrence of the disease in their offsprings.  Suisanzoshoku 41, 327-332. (in Japanese)

Arimoto M., K. Mori, T. Nakai, K. Muroga, and I. Furusawa (1993): Pathogenicity of the causative agent of viral nervous necrosis disease in striped jack, Pseudocaranx dentex (Bloch & Schneider).  J. Fish Dis. 16, 461-469

Mushiake K., M. Arimoto, T. Furusawa, I. Furusawa, T. Nakai, and K. Muroga (1992): Detection of antibodies against striped jack nervous necrosis virus (SJNNV) from brood stocks of striped jack.  Nippon Suisan Gakkaishi 58, 2351-2356.

Arimoto M., K. Mushiake, Y. Mizuta, T. Nakai, K. Muroga, and I. Furusawa (1992): Detection ofstriped jack nervous necrosis virus (SJNNV) by enzyme-linked immunosorbent assay (ELISA).  Fish Pathol. 27, 191-195.

Mori K., T. Nakai, K. Muroga, M. Arimoto, K. Mushiake, and I. Furusawa (1992): Properties of a new virus belonging to Nodaviridae found in larval striped jack (Pseudocaranx dentex) with nervous necrosis. Virology 187, 368-371.

Mori K., T. Nakai, M. Nagahara, K. Muroga, T. Mekuchi, and T. Kanno (1991): A viral disease in hatchery-reared larvae and juveniles of redspotted grouper. Fish Pathol. 26, 209-210.

 

2)      その他のウイルス病 Other viral diseases

Pakingking R. JR, Y. Okinaka, K. Mori, M. Arimoto, K. Muroga and T. Nakai (2004): In vivo and in vitro analysis of the resistance against viral haemorrhagic septicaemia virus in Japanese flounder (Paralichthys olivaceus ) precedingly infected with aquabirnavirus. Fish & Shellfish Immunol., 17, 1-11

Nakai T., K. Mori, K. Muroga, and T. Mekuchi (1991): Diagnosis of viral epidermal hyperplasia of Japanese flounder larvae by fluorescent antibody technique.  Nippon Suisan Gakkaishi 57, 1507-1510.

Iida Y., T. Nakai, M. Sorimachi, and K. Masumura (1991): Histopathology of a herpesvirus infection in larvae of Japanese flounder, Paralichthys olivaceus. J. Aquat. Org. 10, 59-63.

Iida Y., K. Masumura, T. Nakai, M. sorimachi, and H. Matsuda (1989): A viral disease in larvae and juveniles of Japanese flounder, Paralichthys olivaceus.  J. Aquat. Anim. Health. 1, 7-12.

Masumura K., Y. Iida, T. Nakai, and T. Mekuchi (l989): The effects of water temperature and fish age on a herpesvirus infection of Japanese flounder larvae, Paralichthys olivaceus. Fish Pathol. 24, 111-114. (in Japanese)

 

2. 細菌病 Bacterial diseases

Okuda J., Y. Arikawa, Y. Takeuchi, M. M. Mahmoud, E. Suzaki, K. Kataoka, T. Suzuki, Y. Okinaka, T. Nakai (2006): Intracellular replication of Edwardsiella tarda in murine macrophage is dependent on the type III secretion system and induces an up-regulation of anti-apoptotic NF-kB target genes protecting the macrophage from staurosporine-induced apoptosis. Microbial Pathogenesis 41, 226-240

Mahmoud M.M., J. Okuda and T. Nakai (2006): Sodium chloride-enhanced adherence of Edwardsiella tarda. Fish Pathol.  41, 165-170

Okuda J., S. Kanemaru, A. Yuasa, N. Nakaoka, H. Kawakami and T. Nakai (2006): A possible mechanism of quinolone resistance in Vibrio anguillarum. Fish Pathol., 41, 73-75

Kawanishi K., T. Yoshida, S. Yagashiro, M. Kijima, K. Yagyu, T. Nakai, M. Murakami, H. Morita and S. Suzuki (2006): Differences between Lactococcus garvieae isolated from the genus Seriola in Japan and those isolated from other animals (trout, terrestrial animals from Europe) with regard to pathogenicity, phage susceptibility and genetic characterization. J. Appl. Microbiol., 101, 496-504

Yasunobu H., Y. Arikawa, K. Furutsuka-Uozumi, M. Dombo, T. Iida, M.M.Mahmoud, J.Okuda and T. Nakai (2006): Induction of hemagglutinating activity of Edwardsiella tarda by sodium chloride. Fish Pathol., 41, 29-34

Okuda J., T. Nakai, S.C. Park, T. Oh, T. Nishino, T. Koitabashi and M. Nishibuchi (2002): The toxR gene of Vibrio anguillarum: not a virulence regulator but a good tool for diagnosis.  Proceedings of International Commemorative Symposium 70th Anniversary of The Japanese Society of Fisheries Science Fisheries Science vol.68 supplement II, November 2002, The Japanese Society of Fisheries Science Tokyo, Japan

Matsubara D., M. Tanaka, Y. Soumyo, K. Hirakawa, R. Doi, T. nakai (2002) Therapeutic effects of antimicrobial compounds agains bacillary necrosisof larval Pacific oyster. Fish Pathol. 37, 183-188. (in Japanese)

Ooyama T, Y Hirokawa, T Minami, H Yasuda, T Nakai, M Endo, L Ruangpan, T Yoshida (2002): Cell surface properties of Lactococcus garvieae strains and their immunogenicity in yellowtail, Seriola quinqueradiata. Dis. Aquat. Org. 51, 169-177

Park S.C. and T. Nakai (2002): Relationship between in vitro motility of Pseudomonas plecoglossicida and clinical conditions in affected ayu. Fish Pathol., 37, 141-144.

Okuda J., T. Nakai, S.C. Park, T. Oh, T. Nishino, T. Koitabashi and M. Nishibuchi (2001): The toxR gene of Vibrio (Listonella) anguillarum is involved in expression control of the major outer membrane proteins rather than virulence. Infect. Immun. 69:6091-6101

Varaporn Vuddhakul, T. Nakai, C. Matsumoto, T. Oh, T. Nishino, C.H. Chen, M. Nishibuchi, and J. Okuda (2000): Analysis of gyrB and toxR gene sequences of Vibrio hollisae and development of gyrB-and toxR-targeted PCR methods for isolation of V. hollisae from the environment and its identification. Appl. Environ. Microbiol. 66:3506-3514

Park S.-C., I. Shimamura, M. Hagihira, and T. Nakai (2000): A brown pigment-producing strain of Pseudomonas plecoglossicida isolated from ayu with hemorrhagic ascites.  Fish Pathol., 35: 91-92.

Leobert D. de la Pena, T. Nakai and K. Muroga (1998): Experimental infection of kuruma prawn (Penaeus japonicus) with Vibrio penaeicida. Bermidgeh 50: 128-133

Varin Tanasomwang, T. Nakai, Y. Nishimura and K. Muroga (1998): Vibrio-inhibiting marine bacteria isolated from black tiger shrimp hatchery.  Fish Pathol., 33, 459-466

Sugumar, G., T. Nakai, Y. Hirata, D. Matsubara, and K. Muroga (1998): Vibrio splendidus biovar II as the causative agent of bacillary necrosis of Japanese oyster Crassostrea gigas.  Dis. Aquat. Org., 33, 111-116.

Sugumar, G., T. Nakai, Y. Hirata, D. Matsubara, and K. Muroga (1998): Pathogenicity of Vibrio splendidus biovar II, the causative bacterium of bacillary necrosis of Japanese oyster larvae. Fish Pathol., 33, 79-84.

de la Pena L.D., H. Koube, T. Nakai, and K. Muroga (1997): Detection of Vibrio penaeicida in kuruma prawn after transport. Fish Pathol., 32, 233-234.

Nakai, T. Y. Nishimura, and K. Muroga (1997): Detection of Vibrio penaeicida from apparently healthy kuruma prawns by RT-PCR.  Bull. Eur. Ass. Fish Pathol., 17, 131-133.

Rashid, M.M., T. Nakai, K. Muroga, and T. Miyazaki (1997): Pathogenesis of experimental edwardsiellosis in Japanese flounder Paralichthys olivaceus. Fish. Sci., 63, 384-387.

Suprapto H., T. Hara, T. Nakai, and K. Muroga (1996): Purification of a lethal toxin of Edwardsiella tarda.  Fish Pathol., 31, 203-207.

Genmoto K., T. Nishizawa, T. Nakai, and K. Muroga (1996): 16S rRNA targeted RT-PCR for the detection of Vibrio penaeicida, the pathogen of cultured kuruma prawn Penaeus japonicus.  Dis. Aquat. Org., 24, 185-189.

Suprapto H., T. Nakai, and K. Muroga (1995): Toxicity of extracellular products and intracellular components of Edwardsiella tarda in the Japanese eel and flounder. J. Aquat. Anim. Health, 7, 292-297.

Mekuchi T., T. Kiyokawa, K. Honda, T. Nakai, and K. Muroga (1995): Vaccination trials in the Japanese flounder against edwardsiellosis.  Fish Pathol., 30, 251-256. (in Japanese)

Mekuchi T., T. Kiyokawa, K. Honda, T. Nakai, and K. Muroga (1995): Infection experiments with Edwardsiella tarda in the Japanese flounder.  Fish Pathol., 30, 247-250. (in Japanese)

de la Pena L.D., T. Nakai, and K. Muroga (1995): Dynamics of Vibrio sp. PJ in organs of orally infected kuruma prawn, Penaeus japonicus.  Fish Pathol., 30, 39-45.

Mamnur Rashid M., T.Mekuchi, T. Nakai, and K. Muroga (1994): A serological study on Edwardsiella tarda strains isolated from diseased Japanese flounder (Paralichthys olivaceus).  Fish Pathol., 29, 277.

Mamnur Rashid M., K. Honda, T. Nakai, and K. Muroga (1994): An ecological study on Edwardsiella tarda in flounderfarms.  Fish Pathol. 29, 221-227.

de la Pena L.D., T. Tamaki, K. Momoyama, T. Nakai, and K. Muroga (1993): Characteristics of the causative bacterium of vibriosis in the kuruma prawn, Penaeus japonicus.  Aquaculture 115, 1-12

de la Pena L.D., K. Momoyama, T. Nakai, and K. Muroga (1992): Detection of the causative bacterium of vibriosis in kuruma prawn, Penaeus japonicus. Fish Pathol. 27, 223-228.

Kiiyukia C., A. Nakajima, T. Nakai, K. Muroga, H. Kawakami, and H. Hashimoto (1992) Vibrio cholerae non-O1 isolated from ayu fish (Plecoglossus altivelis) in Japan. Appl. Environ. Microbiol. 58, 3078-3082

Kakuta I. and T. Nakai (1992): Blood changes in Japanese eels, Anguilla japonica, experimentally infected with typical or atypical Aeromonas salmonicida.  Comp. Biochem. Physiol. 103A, 151-155

Meguro Y., T. Nakai, K. Muroga, and M. Sorimachi (1991): A cell line derived from the fin of Japanese flounder, Paralichthys olivaceus.  Fish Pathol. 26, 69-75.

Nakai T., N. Fujiie, K. Muroga, M. Arimoto, Y. Mizuta, and S. Matsuoka (1992): Pasteurella piscicida infection in hatchery-reared juvenile striped jack. Fish Pathol. 27, 103-108.

Nakamura Y., T. Nakai, and K. Muroga (1990): Induction of antibody producing cells in some fishes by immunization with Vibrio anguillarum O-antigen.  Fish Pathol. 25,  225-230.  (in Japanese)

Kanno T., T. Nakai, and K. Muroga (l990): Scanning electron microscopy on the skin surface of ayu Plecoglossus altivelis infected with Vibrio anguillarum. Dis. Aquat. Org. 8, 73-75.

Kanno T., T. Nakai, and K. Muroga (1989): Mode of transmission of vibriosis among ayu Plecoglossus altivelis.  J. Aquat. Anim. Health 1, 2-6.

Nakai T., K. Muroga, and K. Masumura (l989): Immersion vaccination of juvenile rockfish Sebastes schlegeli by Vibrio ordalii and Vibrio anguillarum antigens. Suisanzoshoku 37, l29-132.  (in Japanese)

Nakai T., M. Miyakawa, K. Muroga, and K. Kamito (1989): The tissue distribution of atypical Aeromonas salmonicida in artificially infected Japanese eels, Anguilla japonica. Fish Pathol. 24, 23-28.

Nakai T., T. Kanno, E. R. Cruz, and K. Muroga (1987): The effects of iron compounds on the virulence of Vibrio anguillarum in Japanese eels and ayu. Fish Pathol. 22, 185-189.

Kanemori Y., T. Nakai, and K. Muroga (1987): The role of extracellular protease produced by Vibrio anguillarum.  Fish Pathol. 22, 153-158.

Muroga K., M. Iida, H. Matsumoto, and T. Nakai (l986): Detection of Vibrio anguillarum from waters.  Bull. Japan. Soc. Sci. Fish. 52, 641-647.

Nakai T., H. Hanada, and K. Muroga (1985): First records of Pseudomonas anguilliseptica infection in cultured ayu, Plecoglossus altivelis.  Fish Pathol. 20, 481-484. (in Japanese)

Inamura H., T. Nakai, and K. Muroga (1985): An extracellular protease produced by Vibrio anguillarum.  Bull. Japan. Soc. Sci. Fish. 51, 1915-1920.

Nakai T. (1985): Resistance of Pseudomonas anguilliseptica to bactericidal action of fish serum.  Bull. Japan. Soc. Sci. Fish. 51, 1431-1436.

Mushiake K., T. Nakai, and K. Muroga (1985): Lowered phagocytosis in the blood of eels exposed to copper.  Fish Pathol. 20, 49-53. (in Japanese)

Nakai T., K. Muroga, H. Y. Chung, and G. H. Kou (1985): A serological study on Pseudomonas anguilliseptica isolated from diseased eels in Taiwan.  Fish Pathol. 19, 259-261.

Nakai T, Y. Kanemori, K. Nakajima, and K. Muroga (1985): The fate of Pseudomonas anguilliseptica in artificially infected eels Anguilla japonica.  Fish Pathol. 19, 253-258.

Darunee Sae-Oui, K. Muroga, and T. Nakai (1984):  A case of Edwardsiella tarda infection in cultured colored carp Cyprinus carpio.  Fish Pathol. 19, 197-199.

Muroga K., K. Satoh, and T. Nakai (1984): Growth temperature of five bacterial pathogens for eel.  Fish Pathol. 19, 193-196. (in Japanese)

Mushiake K., K. Muroga, and T. Nakai (1984): Increased susceptibility of Japanese eel Anguilla japonica to Edwardsiella tarda and Pseudomonas anguilliseptica following exposure to copper.  Bull. Japan. Soc. Sci. Fish. 50, 1797-1801

Ohtsuka H., T. Nakai, K. Muroga, and Y. Jo (1984): Atypical Aeromonas salmonicida isolated from diseased eels.  Fish Pathol. 19, 101-107.  (in Japanese)

Inamura H., K. Muroga, and T. Nakai (1984): Toxicity of extracellular products of Vibrio anguillarum.  Fish Pathol. 19, 89-96.

Minagawa T., T. Nakai, and K. Muroga (1983): Edwardsiella tarda in eel culture environment.  Fish. Pathol. 17, 243-250.  (in Japanese)

Nakai T., K. Muroga, K. Ohnishi, Y. Jo, and H. Tanimoto (1982): Studies on red spot disease of pond-cultured eels - IX.  A field vaccination trial.  Aquiculture 30, 131-135. (in Japanese)

Nakai T. and K. Muroga (1982): Pseudomonas anguilliseptica isolated from European eels (Anguilla anguilla) in Scotland.  Fish. Pathol. 17, 147-150.  (in Japanese)

Nakai T., K. Muroga, and H. Wakabayashi (1982): An immunoelectrophoretic analysis of Pseudomonas anguilliseptica antigens.  Bull. Japan. Soc. Sci. Fish. 48, 363-367

Nakai T., K. Muroga, and H. Wakabayashi (1981): Serological properties of Pseudomonas anguilliseptica in agglutination.  Bull. Japan. Soc. Sci. Fish. 47, 699-703.

Nakai T. and K. Muroga (1979): Studies on red spot disease of pond-cultured eels - V. Immune response of the Japanese eel to the causative bacterium Pseudomonas anguilliseptica. Bull. Japan. Soc. Sci. Fish., 45, 817-821.

Muroga K., T. Nakai, and T. Sawada (1977): Studies on red spot disease of pond-cultured eels - IV. Physiological characteristics of the causative bacterium, Pseudomonas anguilliseptica.  Fish Pathol. 12(1), 33-38.  (in Japanese)

 

3. バクテリオファージ療法 Bacteriophage therapy

Matsuoka S. and T. Nakai (2004): Seasonal appearance of Edwardsiella tarda and its bacteriophages in the culture farms of Japanese flounder. Fish Pathol., 39, 145-152

Nakai T. (2003): A new approach to control bacterial infections in aquaculture. In : Agrobiotechnology and Plant Tissue Culture (S.S. Bhojwani and W.-Y. Soh eds), pp.165-168, Science Publishers, Enfield, USA.

Park S.C. and T. Nakai (2003): Bacteriophage control of Pseudomonas plecoglossicida infection in ayu. Dis Aquat Org. 53, 33-39

Nakai T. and S.C. Park (2002): Mini-review Bacteriophage therapy of infectious diseases in aquaculture. Res. Microbiol., 153, 13-18.

Park S.-C., I. Shimamura, M. Fukunaga, K. Mori and T. Nakai (2000): Isolation of bacteriophages specific to a fish pathogen, Pseudomonas plecoglossicida, as a candidate for disease control.  Appl. Environ. Microbiol., 66:1416-1422.

Nakai T., R. Sugimoto, K.-H. Park, S. Matsuoka, K. Mori, T. Nishioka, K. Maruyama (1999): Protective effects of bacteriophage on experimental Lactococcus garvieae infection in yellowtail. Dis. Aquat. Org., 37, 33-41

Park, K.H., H. Kato, T. Nakai, and K. Muroga (1998): Phage typing of Lactococcus garvieae (formerly Enterococcus seriolicida) a pathogen of cultured yellowtail. Fish. Sci., 64, 62-64.

Park, K.-H., S. Matsuoka, T. Nakai, and K. Muroga (1997): A virulent bacteriophage of Lactococcus garvieae (formerly Enterococcus seriolicida) isolated from yellowtail Seriola quinqueradiata.  Dis. Aquat. Org., 29, 145-149.

 

4.       総説・解説 Reviews

中井敏博(2007)ヒトと動物の細菌感染症に対するバクテリアファージ療法. 化学療法の領域. Vol.23, No.8, 28-34

中井敏博(2007)バクテリオファージで魚の細菌感染症を防ぐ. 日本水産学会誌. Vol.73, No.4, 795-798

中井敏博(2007)畜産動物および魚類の感染症の現状とその対策(3):魚類のウイルス感染症の現状と対策. Bokin Bonsai. Vol.35, No.2, 119-129

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