原著論文 (1991年より）
Belousoff, M. J., Shapira, T., Bashan, A., Zimmerman, E., Rozenberg, H., Arakawa, K., Kinashi, H. and Yonath, A. (2011) Crystal structure of the synergistic antibiotic pair, lankamycin and lankacidin, in complex with the large ribosomal subunit. Proc. Natl. Acad. Sci. USA, in press.
Suzuki, T., Mochizuki, S., Yamamoto, S., Arakawa, K. and Kinashi, H. (2010) Regulation of lankamycin biosynthesis in Streptomyces rochei by two SARP genes, srrY and srrZ. Biosci. Biotechnol. Biochem., 74, 819-827.
Auerbach, T., Mermershtain, I., Davidovich, C., Bashan, A., Belousoff, M., Wekselman, I., Zimmerman, E., Xiong, L., Klepacki, D., Arakawa, K., Kinashi, H., Mankin, A. and Yonath, A. (2010) The structure of ribosome-lankacidin complex reveals ribosomal sites for synergistic antibiotics. Proc. Natl. Acad. Sci. USA, 107, 1983-1988.
Tatsuno, S., Arakawa, K. and Kinashi, H. (2009) Extensive mutational analysis of modular-iterative mixed biosynthesis of lankacidin in Streptomyces rochei. Biosci. Biotechnol. Biochem., 73, 2712-2719.
Migita, A., Watanabe, M., Hirose, Y., Watanabe, K., Tokiwano, T., Kinashi, H. and Oikawa, H. (2009) Identification of a gene cluster of polyether antibiotic lasalocid from Streptomyces lasaliensis. Biosci. Biotechnol. Biochem., 73, 169-176.
Arakawa, K., Suzuki, T. and Kinashi, H. (2008) Gene disruption analysis of two glycosylation steps in lankamycin biosynthesis in Streptomyces rochei. Actinomycetol., 22, 35-41.
Yamamoto, S., He, Y., Arakawa, K. and Kinashi, H. (2008) gamma-Butyrolactone-dependent expression of the SARP gene srrY plays a central role in the regulatory cascade leading to lankacidin and lankamycin production in Streptomyces rochei. J. Bacteriol., 190, 1308-1316.
Tatsuno, S., Arakawa, K. and Kinashi, H. (2007) Analysis of modular-iterative mixed biosynthesis of lankacidin by heterologous expression and gene fusion. J. Antibiot., 60, 700-708.
Arakawa, K., Mochizuki, S., Yamada, K., Noma, T. and Kinashi, H. (2007) gamma-Butyrolactone autoregulator-receptor system involved in lankacidin and lankamycin production and morphological differentiation in Streptomyces rochei. Microbiology, 153, 1817-1827.
Arakawa, K., Kodama, K., Tatsuno, S., Ide, S. and Kinashi, H. (2006) Analysis of the loading and hydroxylation steps in lankamycin biosynthesis in Streptomyces rochei. Antimicrob. Agents Chemother. 50, 1946-1952.
Arakawa, K., Sugino, F., Kodama, K., Ishii, T. and Kinashi, H. (2005) Cyclization mechanism for the synthesis of macrocyclic antibiotic lankacidin in Streptomyces rochei. Chem. Biol. 12, 249-256.
Yamasaki, M. and Kinashi, H. (2004) Two chimeric chromosomes of Streptomyces coelicolor A3(2) generated by single crossover of the wild-type chromosome and linear plasmid SCP1. J. Bacteriol., 186, 6553-6559.
Uchida, T., Ishihara, N., Zenitani, H., Hiratsu, K. and Kinashi, H. (2004) Circularized chromosome with a large palindromic structure in Streptomyces griseus mutants. J. Bacteriol., 186, 3313-3320.
Bentley, S.D., Brown, S., Murphy, L.D., Harris, D.E., Quail, M.A., Parkhill, J., Barrell, B.G., McCormick, J.R., Santamaria, R.I., Losick, R., Yamasaki, M., Kinashi, H., Chen, C.W., Chandra, G., Jakimowicz, D., Kieser, H.M. and Chater, K.F. (2004) SCP1, a 356,023 base pair linear plasmid adapted to the ecology and developmental biology of its host, Streptomyces coelicolor A3(2). Mol. Microbiol., 51, 1615-1628.
Mochizuki, S., Hiratsu, K., Suwa, M., Ishii, T., Sugino, F., Yamada, K. and Kinashi, H. (2003) The large linear plasmid pSLA2-L of Streptomyces rochei has an unusually condensed gene organization for secondary metabolism. Mol. Microbiol., 48, 1501-1510.
Inoue, S., Higashiyama, K., Uchida, T., Hiratsu, K. and Kinashi H. (2003) Chromosomal circularization in Streptomyces griseus by nonhomologous recombinaton of deletion ends. Biosci. Biotechnol. Biochem., 67, 1101-1108.
Yamasaki, M., Ikuto, Y., Ohira, A., Chater, K. and Kinashi, H. (2003) Limited regions of homology between linear and circular plasmids encoding methylenomycin biosynthesis in two independently isolated streptomycetes. Microbiology, 149, 1351-1356.
Uchida, T., Miyawaki, M. and Kinashi, H. (2003) Chromosomal arm replacement in Streptomyces griseus. J. Bacteriol., 185, 1120-1124.
Arakawa, K., Bowers, S.G., Michels, B., Trin, V. and Mahmud, T. (2003) Biosynthetic studies on the alpha-glucosidase inhibitor acarbose: the chemical synthesis of isotopically labeled 2-epi-5-epi-valiolone analogs. Carbohydr. Res., 338, 2075-2082.
Goshi, K., Uchida, T., Lezhava, A., Yamasaki, M., Hiratsu, H., Shinkawa, H. and Kinashi, H. (2002) Cloning and analysis of the telomere and terminal inverted repeat of the linear chromosome of Streptomyces griseus. J. Bacteriol., 184, 3411-3415.
Inada, K., Kinashi, H., Nimi, O., Hasegawa, T. and Shinkawa, H. (2002) Characterization of the dnaK locus in Streptomyces griseus. Actinomycetologica, 16, 37-40.
Morita, D., Miyoshi, K., Matsui, Y., Toh-e, A., Shinkawa, H., Miyakawa T. and Mizuta, T. (2002) Rpf2p, an evolutionarily conserved protein, interacts with ribosomal protein L11 and is essential for the processing of 27 SB pre-rRNA to 25 S rRNA and the 60 S ribosomal subunit assembly in Saccharomyces cerevisiae. J. Biol. Chem., 277, 28780-28786.
Naganawa, H., Hashizume, H., Kubota, Y., Sawa, R., Takahashi, Y., Arakawa, K., Bowers, S. G., and Mahmud, T. (2002) Biosynthesis of the cyclitol moiety of pyralomicin 1a in Nonomuraea spiralis MI178-34F18. J. Antibiot., 55, 578-584.
Arakawa, K., Muller, R., Mahmud, T., Yu, T.-W., Floss, H. G. (2002) Characterization of the early stage aminoshikimate pathway in the formation of 3-amino-5-hydroxybenzoic acid: the RifN protein specifically converts kanosamine into kanosamine 6-phosphate. J. Am. Chem. Soc., 124, 10644-10645.
Yamasaki, M., Redenbach, M. and Kinashi, H. (2001) Integrated structures of the linear plasmid SCP1 in two bidirectional donor strains of Streptomyces coelicolor A3(2). Mol. Gen. Genet., 264, 634-642.
Hiratsu, K., Mochizuki, S. and Kinashi, H. (2000) Cloning and analysis of the replication origin and the telomeres of the linear plasmid pSLA2-L in Streptomyces rochei. Mol. Gen. Genet., 263, 1015-1021.
Yamasaki, M., Miyashita, K., Cullum, J. and Kinashi, H. (2000) A complex insertion sequence cluster at a point of interaction between the linear plasmid SCP1 and the linear chromosome of Streptomyces coelicolor A3(2). J. Bacteriol., 182, 3104-3110.
Suwa, M., Sugino, H., Mori, E., Sasaoka, A., Fujii, S., Shinkawa, H., Nimi, O. and Kinashi, H. (2000) Identification of two polyketide synthase gene clusters on the linear plasmid pSLA2-L in Streptomyces rochei. Gene, 246, 123-131.
Kameoka, D., Lezhava, A., Zenitani, H., Hiratsu, K., Goshi, K., Kawamoto, M., Inada, K., Shinkawa, H. and Kinashi, H. (1999) Analysis of fusion junctions of circularized chromosomes in Streptomyces griseus. J. Bacteriol., 181, 5711-5717.
Zhang, H., Shinkawa, H., Kinashi, H. and Hasegawa, T. (1999) Protoplasting, regeneration and transformation of rare actinomycetes. Actinomycetologica, 13, 42-48.
Kinashi, H., Fujii, S., Hatani, A., Kurokawa, T. and Shinkawa, H. (1998) Physical mapping of the linear plasmid pSLA2-L and localization of the eryAI and actI homologs. Biosci. Biotech. Biochem., 62, 1892-1897.
Redenbach, M., Ikeda, K., Yamasaki, M. and Kinashi, H. (1998) Cloning and physical mapping of the EcoRI fragments of the giant linear plasmid SCP1. J. Bacteriol., 180, 2796-2799.
Ueda, K., Hsheh, C.-W., Tosaki, T., Shinkawa, H., Beppu, T. and Horinouchi, S. (1998) Characterization of an A-factor-responsive repressor for amfR essential for onset of aerial mycelium formation in Streptomyces griseus. J. Bacteriol., 180, 5085-5093.
Zhang, H., Shinkawa, H., Ishikawa, J., Kinashi, H. and Nimi, O. (1997) Improvement of transformation system in Streptomyces using a modified regeneration medium. J. Ferment. Bioeng., 83, 217-221.
Lezhava, A., Kameoka, D., Sugino, H., Goshi, K., Shinkawa, H., Nimi, O., Horinouchi, S., Beppu, T. and Kinashi, H. (1997) Chromosomal deletions in Streptomyces griseus that remove the afsA locus. Mol. Gen. Genet., 253, 478-483.
Redenbach, M., Kieser, H.M., Denapaite, D., Eichner, A., Cullum, J., Kinashi, H. and Hopwood, D.A. (1996) A set of ordered cosmids and a detailed genetic and physical map for the 8 Mb Streptomyces coelicolor A3(2) chromosome. Mol. Microbiol., 21, 77-96.
Shinkawa, H., Kawamoto, K., Ohmori, Y., Kinashi, H. and Nimi, O. (1996) Cloning and nucleotide sequence of the genes for hrdA and hrdD: Members of rpoD family in Streptomyces griseus. Actinomycetologica, 20, 23-34.
Kuramoto, A., Lezhava, A., Taguchi, S., Momose, H. and Kinashi, H. (1996) The location and deletion of the genes which code for SSI-like protease inhibitors in Streptomyces species. FEMS Microbiol. Lett., 139, 37-42.
Lezhava, A., Mizukami, T., Kajitani, T., Kameoka, D., Redenbach, M., Shinkawa, H., Nimi, O. and Kinashi, H. (1995) Physical map of the linear chromosome of Streptomyces griseus. J. Bacteriol., 177, 6492-6498.
Shinkawa, H., Hatada, Y., Okada, M., Kinashi, H. and Nimi, O. (1995) Nucleotide sequence of a principal sigma factor gene (hrdB) of Streptomyces griseus. J. Biochem., 118, 494-499.
Kinashi, H., Doi, M. and Nimi, O. (1995) Isolation of large linear plasmids from β-lactam-producing Streptomyces strains. Biotechnol. Letters, 17, 243-246.
H. Shinkawa, Fujita, N., Shiina, T., Tanaka, K., Takahashi, H., Ishihama, A. and Nimi, O. (1995) Purification and characterization of RNA polymerase holoenzyme (EσB) from vegetative-phase mycelia of Streptomyces griseus. J. Biochem., 118, 488-493.
Kinashi, H., Mori, E., Hatani, A. and Nimi, O. (1994) Isolation and characterization of large linear plasmids from lankacidin producing Streptomyces species. J. Antibiot., 47, 1447-1455.
Hatada, Y., Shinkawa, H., Kawamoto, K., Kinashi, H. and Nimi, O. (1994) Cloning and nucleotide sequence of a hsp70 gene from Streptomyces griseus. J. Ferment. Bioeng., 77, 461-467.
Hatada, Y., Shinkawa, H., Kinashi, H. and Nimi, O. (1994) Induction of pleiotropic mutation in Streptomyces griseus by incubation under stress conditions for mycelial growth. Biosci. Biotech. Biochem., 58, 990-991.
Doi, K., Gartner, A., Ammerer, G., Errede, B., Shinkawa, H., Sugimoto, K. and Matsumoto, K. (1994) MSG5, a novel protein phosphatase promotes adaptation to pheromone response in S. cerevisiae. EMBO J., 13, 61-70.
Kinashi, H., Murayama, M., Matsushita, H. and Nimi, O. (1993) Structural analysis of the giant linear plasmid SCP1 in various Streptomyces coelicolor strains. J. Gen. Microbiol., 139, 1261-1269.
Kinashi, H., Murayama, M. and Hanafusa, T. (1992) Integration of SCP1, a giant linear plasmid, into the Streptomyces coelicolor chromosome. Gene, 115, 35-41.
Hanafusa, T. and Kinashi, H. (1992) The structure of an integrated copy of the giant linear plasmid SCP1 in the chromosome of Streptomyces coelicolor 2612. Mol. Gen. Genet., 231, 363-368.
Kinashi, H., Shimaji-Murayama, M. and Hanafusa, T. (1991) Nucleotide sequence analysis of the unusually long terminal inverted repeats of a giant linear plasmid, SCP1. Plasmid, 26, 123-130.
Kinashi, H. and Shimaji-Murayama, M. (1991) Physical characterization of SCP1, a giant linear plasmid from Streptomyces coelicolor. J. Bacteriol., 173, 1523-1529.
Ueki, N., Kinashi, H. and Mizuno, T. (1991) Primary characterization of curved DNA segments cloned from Streptomyces DNA with extremely high G/C-contents. Agric. Biol. Chem., 55, 173-180.
Shinkawa, H., Sugiyama, M., Hatada, Y., Ohuchi, T., Udagawa, M. and Nimi, O. (1991) Silence of streptomycin 6-phosphotransferase gene derived by incubation at high temperature in Streptomyces griseus. Biotechnol. Lett., 13, 537-542.
総説・本・紀要など
Arakawa, K. (2010) Characterization of the biosynthetic gene clusters located on the Streptomyces linear plasmid, Actinomycetol., 24, 24-30.
荒川賢治, 木梨陽康 (2008) 線状プラスミド上の抗生物質生合成クラスターの解析とその応用. バイオサイエンスとインダストリー, 66, 504-508.
荒川賢治 (2008) ポリエーテル系抗生物質生合成研究の最近の進歩. ファルマシア, 44, 453-454.
Kinashi, H. (2008) Antibiotic production, linear plasmids and linear chromosomes in Streptomyces, Actinomycetol., 22, 20-29
木梨陽康 (2007) 放線菌の線状レプリコンの再編成とゲノム進化. 化学と生物, 45, 619-626
Chater, K. F. and Kinashi, H. (2007) Streptomyces linear plasmids: their discovery, functions, interactions with other replicons, and evolutionary significance. Microbiology Monographs, Vol. 7, Microbial Linear Plasmids, ed. by Meinhardt, F., and Klassen, R., Springer, Berlin/Heidelberg, Germany, p. 1-31
荒川賢治, 児玉和也, 鈴木夏実, 井手彩洋子, 木梨陽康, 株本浩樹, 有澤章 (2006) １４員環マクロライド抗生物質ランカマイシンのスターターユニットおよび水酸化反応の解析. 第４８回天然有機化合物討論会講演要旨集, 451-456.
木梨陽康 (2004) 放線菌のゲノム構造と生物機能の多様性. 日本農芸化学会誌, 78, 1067-1069.
荒川賢治, 望月進, 杉野文規, 石井達也, 児玉和也, 木梨陽康 (2004) ランカサイジン生合成遺伝子群の機能解析および大員環形成機構の解明. 第４６回天然有機化合物討論会講演要旨集, 485-490.
内田哲也, 木梨陽康 (2003) Streptomyces griseus の線状染色体のダイナミックな構造変化の解析. 応用微生物学研究, 1, 76-84 .
木梨陽康 (1999) 抗生物質を作る細菌, 放線菌の線状プラスミドと線状染色体. バイオテクノロジー講義, pp. 42-49, 朝倉書店.
木梨陽康 (1998) 放線菌の線状染色体のダイナミックな構造変化と染色体の起源・進化. 蛋白質核酸酵素, 43, 1453-1460.
木梨陽康 (1997) 放線菌の線状ゲノム(染色体・プラスミド)の構造と機能の解析. 工学部シリーズ−広島大学工学部, pp. 172-173, 三田出版会.
長谷川徹, 新川英典 (1997) 微生物の新たな機能, 潜在機能の探索と開発. 工学部シリーズ−広島大学工学部, pp. 176-179, 三田出版会.
Shinkawa, H. (1996) Transcription apparatus and its relatives in Streptomyces , Actinomycetologica, 10, 112-120.
木梨陽康 (1996) 放線菌−抗生物質を作る微生物−. 技術最前線８２話−２１世紀の技術社会を拓く, pp. 98-99, 広島大学工学部.
木梨陽康 (1995) 放線菌のゲノム構造：線状プラスミドから線状染色体へ. バイオサイエンスとインダストリー, 53, 763-767.
Kinashi, H. (1994) Linear plasmids from actinomycetes , Actinomycetologica, 8, 87-96.
Kinashi, H. (1994) Pulsed-field gel electrophoresis: Isolation and analysis of large linear plasmids , Methods in Gene Technology, Vol. 2, ed. by Dale J.W. and Sanders P.G., pp. 227-240, JAI Press, London, UK.
新川英典 (1992) 生物工学実験書, 日本生物工学会編, 培風館, 分担執筆.