原著論文

2016

Narushima, M., Uchigashima, M., Yagasaki, Y., Harada, T., Nagumo, Y., Uesaka, N., Hashimoto, K., Aiba, A., Watanabe, M., Miyata, M., Kano, M. The Metabotropic Glutamate Receptor Subtype 1 Mediates Experience-Dependent Maintenance of Mature Synaptic Connectivity in the Visual Thalamus. Neuron91, 1097-1109 (2016)

Miyake, K., Ohta, T., Nakayama, H., Doe, N., Terao, Y., Oiki, E., Nagatomo, I., Yamashita, Y., Abe, T., Nishikura, K., Kumanogoh, A., Hashimoto, K., Kawahara, Y. CAPS1 RNA Editing Promotes Dense Core Vesicle Exocytosis. Cell Rep.17, 2004-2014 (2016)

Matsumoto-Makidono, Y., Nakayama, H., Yamasaki, M., Miyazaki, T., Kobayashi, K., Watanabe, M., Kano, M., Sakimura, K., Hashimoto, K. Ionic Basis for Membrane Potential Resonance in Neurons of the Inferior Olive. Cell Rep.16, 994-1004 (2016)

Ichikawa, R., Hashimoto, K., Miyazaki, T., Uchigashima, M., Yamasaki, M., Aiba, A., Kano, M., Watanabe, M. Territories of heterologous inputs onto Purkinje cell dendrites are segregated by mGluR1-dependent parallel fiber synapse elimination. Proc Natl Acad Sci U S A.113, 2282-2287 (2016).

2015

Morino, H., Matsuda, Y., Muguruma, K., Miyamoto, R., Ohsawa, R., Ohtake, T., Otobe, R., Watanabe, M., Maruyama, H., Hashimoto, K., Kawakami, H. A mutation in the low voltage-gated calcium channel CACNA1G alters the physiological properties of the channel, causing spinocerebellar ataxia. Mol Brain.8:89 (2015).

Ageta-Ishihara, N., Yamazaki, M., Konno, K., Nakayama, H., Abe, M., Hashimoto, K., Nishioka, T., Kaibuchi, K., Hattori, S., Miyakawa, T., Tanaka, K., Huda, F., Hirai, H., Hashimoto, K., Watanabe, M., Sakimura, K., Kinoshita, M. A CDC42EP4/septin-based perisynaptic glial scaffold facilitates glutamate clearance. Nat. Commun.6:10090 (2015).

Muguruma, K., Nishiyama, A., Kawakami, H., Hashimoto, K., Sasai, Y. Self-organization of polarized cerebellar tissue in 3D culture of human pluripotent stem cells. Cell Rep. 10, 537-550 (2015).


2014

Kawata, S., Miyazaki, T., Yamazaki, M., Mikuni, T., Yamasaki, M., Hashimoto, K., Watanabe, M., Sakimura, K. & Kano, M. Global scaling down of excitatory postsynaptic responses in cerebellar purkinje cells impairs developmental synapse elimination. Cell Rep. 8, 1119-1129 (2014).

Piochon C, Kloth AD, Grasselli G, Titley HK, Nakayama H, Hashimoto K, Wan V, Simmons DH, Eissa T, Nakatani J, Cherskov A, Miyazaki T, Watanabe M, Takumi T, Kano M, Wang SS, Hansel C. Cerebellar plasticity and motor learning deficits in a copy-number variation mouse model of autism. Nat. Commun. 5, 5586 (2014).


Ohtani, Y., Miyata, M., Hashimoto, K., Tabata, T., Kishimoto, Y., Fukaya, M., Kase, D., Kassai, H., Nakao, K., Hirata, T., Watanabe, M., Kano, M., & Aiba, A. The synaptic targeting of mGluR1 by its carboxyl-terminal domain is crucial for cerebellar function. J. Neurosci. 34, 2702-2712 (2014).

2013


Kawamura, Y., Nakayama, H., Hashimoto, K., Sakimura, K., Kitamura, K. & Kano, M. Spike timing-dependent selective strengthening of single climbing fiber inputs to Purkinje cells during cerebellar development. Nat. Commun. 4, 2732 (2013)

Takeda, I., Takahashi, T., Ueno, H., Morino, H., Ochi, K., Nakamura, T., Hosomi, N., Kawakami, H., Hashimoto, K., Matsumoto M. Autosomal recessive Andersen?Tawil syndrome with a novel mutation L94P in Kir2.1. , Neurology and Clinical Neuroscience 1 (2013)

2012


Uesaka, N., Mikuni, T., Hashimoto, K., Hirai, H., Sakimura, K. & Kano, M. Organotypic coculture preparation for the study of developmental synapse elimination in mammalian brain. J. Neurosci. 32, 11657-11670 (2012)

Tanimura, A., Uchigashima, M., Yamazaki, M., Uesaka, N., Mikuni, T., Abe, M., Hashimoto, K., Watanabe, M., Sakimura, K. & Kano, M. Synapse type-independent degradation of the endocannabinoid 2-arachidonoylglycerol after retrograde synaptic suppression. Proc. Natl. Acad. Sci. U S A. 109, 12195-12200 (2012)

Nakayama H, Miyazaki T, Kitamura K, Hashimoto K, Yanagawa Y, Obata K, Sakimura K, Watanabe M, Kano M. GABAergic Inhibition Regulates Developmental Synapse Elimination in the Cerebellum. Neuron 74, 384-396 (2012)

Miyazaki T, Yamasaki M, Hashimoto K, Yamazaki M, Abe M, Usui H, Kano M, Sakimura K, Watanabe M. Cav2.1 in Cerebellar Purkinje Cells Regulates Competitive Excitatory Synaptic Wiring, Cell Survival, and Cerebellar Biochemical Compartmentalization. J. Neurosci. 32, 1311-1328 (2012)


2011

Ichikawa, R., Yamasaki, M., Miyazaki, T., Konno, K., Hashimoto, K., Tatsumi, H., Inoue, Y., Kano, M., Watanabe, M. Developmental switching of perisomatic innervation from climbing fibers to Basket cell fibers in cerebellar Purkinje cells. J Neurosci. 31, 16916-16927 (2011)

Hashimoto, K., Tsujita, M., Miyazaki, T., Kitamura, K., Yamazaki, M., Shin, H.S., Watanabe, M., Sakimura, K. Kano, M Postsynaptic P/Q-type Ca2+ channels in cerebellar Purkinje cells mediate synaptic competition among multiple climbing fiber inputs during postnatal development. Proc. Natl. Acad. Sci. USA. 108, 9987-9992 (2011)

Miyata, M., Kishimoto, Y., Tanaka, M., Hashimoto, K., Hirashima, N., Murata, Y., Kano, M., Takagishi, Y.. A Role for Myosin Va in Cerebellar Plasticity and Motor Learning: A Possible Mechanism Underlying Neurological Disorder in Myosin Va Disease. J Neurosci. 31, 6067-6078 (2011)


2010

Tanimura, A., Yamazaki, M., Hashimotodani, Y., Uchigashima, M., Kawata, S., Abe, M., Kita, Y., Hashimoto, K., Shimizu, T., Watanabe, M., Sakimura, K. & Kano, M. The endocannabinoid 2-arachidonoylglycerol produced by diacylglycerol lipase α mediates retrograde suppression of synaptic transmission. Neuron 65, 320-327 (2010)

2009

Taniguchi, S., Nakazawa, T., Tanimura, A., Kiyama, Y., Tezuka, T., Watabe, AM., Katayama, N., Yokoyama, K., Inoue, T., Izumi-Nakaseko, H., Kakuta, S., Sudo, K., Iwakura, Y., Umemori, H., Inoue, T., Murphy, NP., Hashimoto, K., Kano, M., Manabe, T. & Yamamoto, T. Involvement of NMDAR2A tyrosine phosphorylation in depression-related behavior. EMBO J 28, 3717-3729 (2009)

Hashimoto, K., Ichikawa, R., Kitamura, K., Watanabe, M. & Kano, M. Selective translocation of the “winner” climbing fiber to Purkinje cell dendrite and subsequent elimination of the “loser” from the soma during cerebellar development. Neuron 63, 106-118 (2009).

Tanimura, A., Kawata, S., Hashimoto, K. & Kano, M. Not glutamate but endocannabinoids mediate retrograde suppression of cerebellar parallel fiber to Purkinje cell synaptic transmission in young adult rodents. Neuropharmacology 57, 157-163 (2009).

2007

Ohkawa, N., Hashimoto, K., Hino, T., Migishima, R., Yokoyama, M., Kano, M. & Inokuchi, K. Motor discoordination of transgenic mice overexpressing a microtubule destabilizer, stathmin, specifically in Purkinje cells. Neurosci. Res. 59, 93-100 (2007). 

Kakizawa, S., Kishimoto, Y., Hashimoto, K., Miyazaki, T., Furutani, K., Shimizu, H., Fukaya, M., Nishi, M., Sakagami, H., Ikeda, A., Kondo, H., Kano, M., Watanabe, M., Iino, M. & Takeshima, H. Junctophilin-mediated channel crosstalk essential for cerebellar synaptic plasticity. EMBO J. 26, 1924-1933 (2007).

Kina, S., Tezuka, T., Kusakawa, S., Kishimoto, Y., Kakizawa, S., Hashimoto, K., Ohsugi, M., Kiyama, Y., Horai, R., Sudo, K., Kakuta, S., Iwakura, Y., Iino, M., Kano, M., Manabe, T. and Yamamoto, T. Involvement of protein-tyrosine phosphatase PTPMEG in motor learning and cerebellar long-term depression. Eur. J. Neurosci. 26, 2269-2278 (2007).

Takagishi, Y., Hashimoto, K., Kayahara, T., Watanabe, M., Otsuka, H., Mizoguchi, A., Kano, M. & Murata, Y. Diminished climbing fiber innervation of Purkinje cells in the cerebellum of myosin Va mutant mice and rats. Dev. Neurobiol. 67, 909-923 (2007).

Tabata, T., Kawakami, D., Hashimoto, K., Kassai, H., Yoshida, T., Hashimotodani, Y., Fredholm, B., Sekino, Y., Aiba, A. & Kano, M. G protein-Independent Neuromodulatory Action of Adenosine on Metabotropic Glutamate Signaling in Mouse Cerebellar Purkinje Cells. J. Physiol. 581, 693-708 (2007). 

Narushima, M., Uchigashima, M., Fukaya, M., Matsui, M., Manabe, T., Hashimoto, K., Watanabe, M. & Kano, M. Tonic enhancement of endocannabinoid-mediated retrograde suppression of inhibition by cholinergic interneuron activity in the striatum. J. Neurosci. 27, 496-506 (2007).

2006

Narushima, M., Uchigashima, M., Hashimoto, K., Watanabe, M. & Kano, M. Depolarization-induced suppression of inhibition mediated by endocannabinoids at synapses from fast-spiking interneurons to medium spiny neurons in the striatum. Eur. J. Neurosci. 24, 2246-2252 (2006).

Yamasaki, M., Hashimoto, K. & Kano, M. Miniature synaptic events elicited by presynaptic Ca2+ rise are selectively suppressed by cannabinoid receptor activation in cerebellar Purkinje cells. J. Neurosci. 26, 86-95 (2006).

Narushima, M., Hashimoto, K. & Kano, M. Endocannabinoid-mediated short-term suppression of excitatory synaptic transmission to medium spiny neurons in the striatum. Neurosci. Res. 54, 159-164 (2006).

Miyazaki, T., Hashimoto, K., Uda, A., Sakagami, H., Nakamura, Y., Saito, S. Y., Nishi, M., Kume, H., Tohgo, A., Kaneko, I., Kondo, H., Fukunaga, K., Kano, M., Watanabe, M. & Takeshima, H. Disturbance of cerebellar synaptic maturation in mutant mice lacking BSRPs, a novel brain-specific receptor-like protein family. FEBS Lett. 580, 4057-4064 (2006).

Kawamura, Y., Fukaya, M., Maejima, T., Yoshida, T., Miura, E., Watanabe, M., Ohno-Shosaku, T., Kano, M. The CB1 cannabinoid receptor is the major cannabinoid receptor at excitatory presynptic site in the hippocampus and cerebellum J. Neurosci. 26, 2991-3001 (2006)


2005年以前

Tabata, T., Haruki, S., Nakayama, H., Kano, M. GABAergic activation of an inwardly rectifying K+ current in mouse cerebellar Purkinje cells. J. Physiol. 563, 443-457 (2005)

Tabata, T., Araishi, K., Hashimoto, K., Hashimotodani, Y., van der Putten, H., Bettler, B. & Kano, M. Ca2+ activity at GABAB receptors constitutively promotes metabotropic glutamate signaling in the absence of GABA. Proc. Natl. Acad. Sci. USA 101, 16952-16957 (2004).

Sato, M., Tabata, T., Hashimoto, K., Nakamura, K., Nakao, K., Katsuki, M., Kitano, J., Moriyoshi, K., Kano, M. & Nakanishi, S. Altered agonist sensitivity and desensitization of neuronal mGluR1 responses in knock-in mice by a single amino acid substitution at the PKC phosphorylation site. Eur. J. Neurosci. 20, 947-955 (2004).

Miyazaki, T., Hashimoto, K(共同第一著者)., Shin, H. S., Kano, M. & Watanabe, M. P/Q-type Ca2+ channel α1A regulates synaptic competition on developing cerebellar Purkinje cells. J. Neurosci. 24, 1734-1743 (2004).

Kitao, Y., Hashimoto, K., Matsuyama, T., Iso, H., Tamatani, T., Hori, O., Stern, D. M., Kano, M., Ozawa, K. & Ogawa, S. ORP150/HSP12A regulates Purkinje cell survival: a role for endoplasmic reticulum stress in cerebellar development. J. Neurosci. 24, 1486-1496 (2004).

Manita, S., Kawamura, Y., Sato, K., Inoue, M., Kudo, Y., Miyakawa, H. Predominant contribution of N-type Ca2+ channels for glutamate release at rat CA3-CA1 synapses. Eur. J. Pharmacol. 499, 265-274 (2004)

Nakayama, H., Oda, Y. Common Sensory Inputs and Differential Excitability of Segmentally Homologous Reticulospinal Neurons in the Hindbrain. J. Neurosci. 24, 3199-3209 (2004)

Kawamura, Y., Manita, S., Nakamura, T., Inoue, M., Kudo, Y., Miyakawa, H. Glutamate release increases during mossy-CA3 LTP, but not during Schaffer-CA1 LTP. Eur. J. Neurosci. 19, 1591-1600 (2004)

Takeda, Y., Akasaka, K., Lee, S., Kobayashi, S., Kawano, H., Murayama, S., Takahashi, N., Hashimoto, K., Kano, M., Asano, M., Sudo, K., Iwakura, Y. & Watanabe, K. Impaired motor coordination in mice lacking neural recognition molecule NB-3 of the contactin/F3 subgroup. J. Neurobiol. 56, 252-265 (2003).

Hashimoto, K. & Kano, M. Functional differentiation of multiple climbing fiber inputs during synapse elimination in the developing cerebellum. Neuron 38, 785-796 (2003).

Kasuga, A., Enoki, R., Hashimoto, Y., Akiyama, H., Kawamura, Y., Inoue, M., Kudo, Y., Miyakawa, H. Optical detection of dendritic spike initiation in hippocampal CA1 pyramidal neuron. Neuroscience 118, 899-907 (2003) .

Yoshida, T., Hashimoto, K., Zimmer, A., Maejima, T., Araishi, K. & Kano, M. The cannabinoid CB1 receptor mediates retrograde signals for depolarization-induced suppression of inhibition in cerebellar Purkinje cells. J. Neurosci. 22, 1690-1697 (2002).

Watase, K., Weeber, E. J., Xu, B., Antalffy, B., Yuva-Paylor, L., Hashimoto, K., Kano, M., Atkinson, R., Sun, Y., Armstrong, D. L., Sweatt, J. D., Orr, H. T., Paylor, R. & Zoghbi, H. Y. A long CAG repeat in the mouse Sca1 locus replicates SCA1 features and reveals the impact of protein solubility on selective neurodegeneration. Neuron 34, 905-919 (2002).

Nishi, M., Hashimoto, K., Kuriyama, K., Komazaki, S., Kano, M., Shibata, S. & Takeshima, H. Motor discoordination in mutant mice lacking junctophilin type 3. Biochem. Biophys. Res. Commun. 292, 318-324 (2002).

Miyata, M., Kim, H. T., Hashimoto, K., Lee, T. K., Cho, S. Y., Jiang, H., Wu, Y., Jun, K., Wu, D., Kano, M. & Shin, H. S. Deficient long-term synaptic depression in the rostral cerebellum correlated with impaired motor learning in phospholipase Cβ4 mutant mice. Eur. J. Neurosci. 13, 1945-1954 (2001).

Maejima, T., Hashimoto, K., Yoshida, T., Aiba, A. & Kano, M. Presynaptic inhibition caused by retrograde signal from metabotropic glutamate to cannabinoid receptors. Neuron 31, 463-475 (2001).

Hashimoto, K., Ichikawa, R., Takechi, H., Inoue, Y., Aiba, A., Sakimura, K., Mishina, M., Hashikawa, T., Konnerth, A., Watanabe, M. & Kano, M. Roles of glutamate receptor δ2 subunit (GluRδ2) and metabotropic glutamate receptor subtype 1 (mGluR1) in climbing fiber synapse elimination during postnatal cerebellar development. J. Neurosci. 21, 9701-9712 (2001).

McGee, A. W., Topinka, J. R., Hashimoto, K., Petralia, R. S., Kakizawa, S., Kauer, F., Aguilera-Moreno, A., Wenthold, R. J., Kano, M. & Bredt, D. S. PSD-93 knock-out mice reveal that neuronal MAGUKs are not required for development or function of parallel fiber synapses in cerebellum. J. Neurosci. 21, 3085-3091 (2001).

Miyata, M., Finch, E. A., Khiroug, L., Hashimoto, K., Hayasaka, S., Oda, S. I., Inouye, M., Takagishi, Y., Augustine, G. J. & Kano, M. Local calcium release in dendritic spines required for long-term synaptic depression. Neuron 28, 233-244 (2000).

Ichise, T., Kano, M., Hashimoto, K., Yanagihara, D., Nakao, K., Shigemoto, R., Katsuki, M. & Aiba, A. mGluR1 in cerebellar Purkinje cells essential for long-term depression, synapse elimination, and motor coordination. Science 288, 1832-1835 (2000).

Miyata, M., Okada, D., Hashimoto, K., Kano, M. & Ito, M. Corticotropin-releasing factor plays a permissive role in cerebellar long-term depression. Neuron 22, 763-775 (1999).

Hashimoto, K., Fukaya, M., Qiao, X., Sakimura, K., Watanabe, M. & Kano, M. Impairment of AMPA receptor function in cerebellar granule cells of ataxic mutant mouse stargazer. J. Neurosci. 19, 6027-6036 (1999).

Watase, K., Hashimoto, K., Kano, M., Yamada, K., Watanabe, M., Inoue, Y., Okuyama, S., Sakagawa, T., Ogawa, S., Kawashima, N., Hori, S., Takimoto, M., Wada, K. & Tanaka, K. Motor discoordination and increased susceptibility to cerebellar injury in GLAST mutant mice. Eur. J. Neurosci. 10, 976-988 (1998).

Watanabe, D., Inokawa, H., Hashimoto, K., Suzuki, N., Kano, M., Shigemoto, R., Hirano, T., Toyama, K., Kaneko, S., Yokoi, M., Moriyoshi, K., Suzuki, M., Kobayashi, K., Nagatsu, T., Kreitman, R. J., Pastan, I. & Nakanishi, S. Ablation of cerebellar Golgi cells disrupts synaptic integration involving GABA inhibition and NMDA receptor activation in motor coordination. Cell 95, 17-27 (1998).

Kano, M., Hashimoto, K., Watanabe, M., Kurihara, H., Offermanns, S., Jiang, H., Wu, Y., Jun, K., Shin, H. S., Inoue, Y., Simon, M. I. & Wu, D. Phospholipase cβ4 is specifically involved in climbing fiber synapse elimination in the developing cerebellum. Proc. Natl. Acad. Sci. USA 95, 15724-15729 (1998).

Hashimoto, K. & Kano, M. Presynaptic origin of paired-pulse depression at climbing fibre- Purkinje cell synapses in the rat cerebellum. J. Physiol. 506, 391-405 (1998).

Offermanns, S., Hashimoto, K.(共同第一著者) , Watanabe, M., Sun, W., Kurihara, H., Thompson, R. F., Inoue, Y., Kano, M. & Simon, M. I. Impaired motor coordination and persistent multiple climbing fiber innervation of cerebellar Purkinje cells in mice lacking Gαq. Proc. Natl. Acad. Sci. USA 94, 14089-14094 (1997).

Kurihara, H., Hashimoto, K., Kano, M., Takayama, C., Sakimura, K., Mishina, M., Inoue, Y. & Watanabe, M. Impaired parallel fiber-->Purkinje cell synapse stabilization during cerebellar development of mutant mice lacking the glutamate receptor d2 subunit. J. Neurosci. 17, 9613-9623 (1997).

Kano, M., Hashimoto, K., Kurihara, H., Watanabe, M., Inoue, Y., Aiba, A. & Tonegawa, S. Persistent multiple climbing fiber innervation of cerebellar Purkinje cells in mice lacking mGluR1. Neuron 18, 71-79 (1997).

Miyata, M., Hashimoto, K., Kano, M. & Ito, M. Corticotropin releasing factor (CRF) induces long-lasting depression of parallel fiber to Purkinje cell synaptic transmission in rat cerebellum. J. Physiol. (Paris) 90, 419-420 (1996).

Chen, C., Kano, M., Abeliovich, A., Chen, L., Bao, S., Kim, J. J., Hashimoto, K., Thompson, R. F. & Tonegawa, S. Impaired motor coordination correlates with persistent multiple climbing fiber innervation in PKCγ mutant mice. Cell 83, 1233-1242 (1995).

Kano, M., Hashimoto, K., Chen, C., Abeliovich, A., Aiba, A., Kurihara, H., Watanabe, M., Inoue, Y. & Tonegawa, S. Impaired synapse elimination during cerebellar development in PKCγ mutant mice. Cell 83, 1223-1231 (1995).


英文総説


Hashimoto, K. & Kano, M. Synapse elimination in the developing cerebellum. Cellular and Molecular Life Sciences, 70, 4667-4680 (2013).

Kano, M., Nakayama, H., Hashimoto, K., Kitamura, K., Sakimura, K., Watanabe, M. Calcium-dependent regulation of climbing fibre synapse elimination during postnatal cerebellar development. J. Physiol.. 591, 3151-3158 (2013)

Kano M, Hashimoto K. Activity-Dependent Maturation of Climbing Fiber to Purkinje Cell Synapses during Postnatal Cerebellar Development. Cerebellum. 11, 449-450 (2012)


Yamazaki, M., Fukaya, M., Hashimoto, K., Yamasaki, M., Tsujita, M., Itakura, M., Abe, M., Natsume, R., Takahashi, M., Kano, M., Sakimura, K. & Watanabe, M. TARPs γ-2 and γ-7 are essential for AMPA receptor expression in the cerebellum. Eur. J. Neurosci. 31, 2204-2220 (2010)

Kano, M. & Hashimoto, K. Synapse elimination in the central nervous system. Curr. Opin. Neurobiol. 19, 154-161 (2009).

Hashimoto, K., Yoshida, T., Sakimura, K., Mishina, M., Watanabe, M. & Kano, M. Influence of parallel fiber-purkinje cell synapse formation on postnatal development of climbing fiber-purkinje cell synapses in the cerebellum. Neuroscience. 162, 601-611 (2009).

Kano, M., Hashimoto, K. & Tabata, T. Type-1 metabotropic glutamate receptor in cerebellar Purkinje cells: a key molecule responsible for long-term depression, endocannabinoid signalling and synapse elimination. Philos. Trans. R. Soc. Lond. B Biol. Sci. 363, 2173-2186 (2008).

Hashimoto, K. & Kano, M. Postnatal development and synapse elimination of climbing fiber to Purkinje cell projection in the cerebellum. Neurosci. Res. 53, 221-228 (2005).

Kano, M., Ohno-Shosaku, T., Maejima, T., Yoshida, T. & Hashimoto, K.    Retrograde modulation of synaptic transmission mediated by endogenous cannabinoids. Curr. Neuropharmacol. 2, 49-57 (2004).

Hashimoto, K., Miyata, M., Watanabe, M. & Kano, M. Roles of phospholipase Cβ4 in synapse elimination and plasticity in developing and mature cerebellum. Mol. Neurobiol. 23, 69-82 (2001).

Hashimoto, K., Watanabe, M., Kurihara, H., Offermanns, S., Jiang, H., Wu, Y., Jun, K., Shin, H. S., Inoue, Y., Wu, D., Simon, M. I. & Kano, M. Climbing fiber synapse elimination during postnatal cerebellar development requires signal transduction involving Gαq and phospholipase Cβ4. Prog. Brain Res. 124, 31-48 (2000).


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神経生理学


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