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Takano M, Otani Y, Tanda M, Kawami M, Nagai J, Yumoto R. Paclitaxel-resistance conferred by altered expression of efflux and influx transporters for paclitaxel in the human hepatoma cell line, HepG2.$@!!(JDrug Metab Pharmacokinet. 24(5):418-427 (2009)Katsube T, Yano Y, Wajima T, Yamano Y, Takano M. Pharmacokinetic/pharmacodynamic modeling and simulation to determine effective dosage regimens for doripenem.J Pharm Sci. 2009 Nov 10. [Epub ahead of print]
Sato K, Nagai J, Mitsui N, Ryokoyumoto, Takano M. Effects of endocytosis inhibitors on internalization of human IgG by Caco-2 human intestinal epithelial cells.$@!!(J
Life Sci. 2009 Oct 30. [Epub ahead of print]
Tanaka Y, Inkyo M, Yumoto R, Nagai J, Takano M, Nagata S. Nanoparticulation of poorly water soluble drugs using a wet-mill process and physicochemical properties of the nanopowders.$@!!(J Chem Pharm Bull (Tokyo). 57(10):1050-1057 (2009)
Ikehata M, Yumoto R, Kato Y, Nagai J, Takano M. Mechanism of insulin uptake in rat alveolar type II and type I-like epithelial cells.$@!!(JBiol Pharm Bull. 32(10):1765-1769 (2009)
Fujii K, Nagai J, Sawada T, Yumoto R, Takano M. Effect of PEGylation of N-WASP181-200 on the Inhibitory Potency for Renal Aminoglycoside Accumulation. Bioconjug Chem. 20(8): 1553-1558 (2009)
Yumoto R, Hamada S, Okada K, Kato Y, Ikehata M, Nagai J, Takano M. Effect of ursodeoxycholic acid treatment on the expression and function of multidrug resistance-associated protein 2 in rat intestine. J Pharm Sci. 98(8):2822-2831 (2009)
Tagawa M, Yumoto R, Oda K, Nagai J, Takano M. Low-affinity transport of FITC-albumin in alveolar type II epithelial cell line RLE-6TN. Drug Metab Pharmacokinet. 23(5):318-327 (2008)
Yumoto R, Tagawa M, Nagai J, Sakai M, Kuwata N, Kihira K, Ishino T, Hirakawa K, and Takano M. Clinical effects of Neo-Burow$@!G(Js solution and important points in its preparation. Jpn J Health Care Sci. 34(10):951-955 (2008)
Katsube T, Yano Y, Yamano Y, Munekage T, Kuroda N, Takano M. Pharmacokinetic-pharmacodynamic modeling and simulation for bactericidal effect in an in vitro dynamic model. J Pharm Sci. 97(9):4108-4117 (2008).
Vaara M, Fox J, Loidl G, Siikanen O, Apajalahti J, Hansen F, Frimodt-Møller N, Nagai J, Takano M, Vaara T. Novel polymyxin derivatives carrying only three positive charges are effective antibacterial agents. Antimicrob Agents Chemother. 52(9):3229-3236 (2008)
Taogoshi T, Nagai J, Yumoto R and Takano M. Transport of prostaglandin E1 across rat erythrocyte membrane. Biol. Pharm. Bull. 31(6):1288-1291(2008)
Ikehata M, Yumoto R, Nakamura K, Nagai J, Takano M. Comparison of Albumin Uptake in Rat Alveolar Type II and Type I-like Epithelial Cells in Primary Culture. Pharm. Res. 25(4)913-922 (2008)
Murakami S, Nagai J, Fujii K, Yumoto R, Takano M.Influences of dosage regimen and co-administration of low-molecular weight proteins and basic peptides on renal accumulation of arbekacin in mice. J Antimicrob Chemother. 61(3)658-664 (2008)
Ikehata M, Yumoto R, Nakamura K, Nagai J, Takano M. Comparison of Albumin Uptake in Rat Alveolar Type II and Type I-like Epithelial Cells in Primary Culture. Pharm Res. 25(4)913-922 (2008)
Yokooji, T., Murakami, T., Nagai, J. and Takano, M.: Role of intestinal efflux transporters in the intestinal absorption of methotrexate in rats. J. Pharm. Pharmacol., 59(9):1263-1270 (2007)
Patanasethanont D, Nagai J, Matsuura C, Fukui K, Sutthanut K, Sripanidkulchai BO, Yumoto R and Takano M. Modulation of function of multidrug resistance associated-proteins by Kaempferia parviflora extracts and their components. Eur. J. Pharmacol.; 566(1-3), 67-74 (2007)
Yokooji, T., Murakami, T., Nagai, J. and Takano, M.: Site-specific bidirectional efflux of 2,4-dinitrophenyl-S-glutathione, a substrate of multidrug resistance-associated proteins, in rat intestine and Caco-2 cells. J. Pharm. Pharmacol., 59(4):513-520 (2007)
Patanasethanont, D., Nagai, J., Yumoto, R., Murakami, T., Sutthanut, K., Sripanidkulchai, B., Yenjai, C. and Takano, M.Effects of Kaempferia parviflora extracts and their flavone constituents on P-glycoprotein function. J. Pharm. Sci., 96(1) 223-233 (2006)
Ogawa, K., Yumoto, R., Hamada, N., Nagai, J. and Takano, M.: Interaction of valproic acid and carbapenem antibiotics with multidrug resistance-associated proteins in erythrocyte membranes. Epilepsy Res., 71, 76-87 (2006)
Yokooji, T., Murakami, T., Yumoto, R., Nagai, J. and Takano, M.: Function of multidrug resistance-associated protein 2 in acute hepatic failure rats. Eur. J. Pharmacol., 546(1-3), 152-160, 2006.
Nagai J., Taogoshi T., Tokunaga, A., Nishikawa H., Murakami T., Takano M.: Characterization of prostaglandin E1 transport in rat renal brush-border membrane, Drug Metabol. Pharmacokin., 21(3), 186-193 (2006)
Nagai J., Saito M., Adachi Y., Yumoto R., Takano M.: Inhibition of gentamicin binding to rat renal brush-border membrane by megalin ligands and basic peptides, J. Control. Release, 112(1):43-50, (2006)
Yumoto R, Nishikawa H, Okamoto M, Katayama H, Nagai J, Takano M.: Clathrin-mediated endocytosis of FITC-albumin in alveolar type II epithelial cell line RLE-6TN. Am J Physiol Lung Cell Mol Physiol. 290(5):L946-955, (2006)
Junyaprasert VB, Soonthornchareonnon N, Thongpraditchote S, Murakami T, Takano M.: Inhibitory effect of thai plant extracts on P-glycoprotein mediated efflux. Phytother. Res. 20(1):79-81 (2006)
Nagai, J., Nasu, R., Murakami T. and Takano M.: Characterization of prostaglandin E1 transport by rat renal cortical slices. Eur. J. Pharmacol., 525(1-3):128-134 (2005)
Yokooji, T., Murakami, T., Ogawa, K., Yumoto, R., Nagai, J. and Takano, M.: Modulation of intestinal transport of 2,4-dinitrophenyl-S-glutathione, a multidrug resistance-associated protein 2 substrate, by bilirubin treatment in rats. J. Pharm. Pharmacol., 57(5), 579-585 (2005)
Omoda, K., Murakami, T., Yumoto, R., Nagai, J., Maeda, Y., Kiribayashi, Y. and Takano, M.: Increased erythrocyte distribution of valproic acid in pharmacokinetic interaction with carbapenem antibiotics in rat and human. J. Pharm. Sci., 94(8), 1685-1693 (2005)
Funakoshi, S., Murakami, T., Yumoto, R., Kiribayashi, Y. and Takano, M.: Role of organic anion transporting polypeptide 2 in pharmacokinetics of digoxin and beta-methyldigoxin in rats. J. Pharm. Sci., 94(6), 1196-1203 (2005)
Ikeda, H., Murakami, T., Takano, M., Usui, T. and Kihira, K.: Pharmacokinetic interaction on valproic acid and recurrence of epileptic seizures during chemotherapy in an epileptic patient. Br. J. Clin. Pharmacol., 59(5), 593-597 (2005)
Taogoshi, T., Nomura, A., Murakami, T., Nagai, J. and Takano, M.: Transport of prostaglandin E1 across the blood-brain barrier in rats. J. Pharm. Pharmacol., 57, 61-66 (2005)
Ishibashi, Y., Murakami T., Yumoto, R., Sakai, M., Shintani, H., Itaha, H., Kanbe, M., Masuda, S., Yajin, K., Kihira, K., and Takano, M.: Pharmaceutical and pharmacological evaluation of Burow's solution (aluminum acetate solution), a hospital preparation, and development of its rapid preparation method. Yakugaku Zasshi, 124 (11), 833-840 (2004)
Takano M., Koyama Y., Nishikawa H., Murakami, T. and Yumoto, R.: Segment-selective absorption of lysozyme in the intestine. Eur. J. Pharmacol., 502 (1-2), 149-155 (2004)Maeda, Y., Kiribayashi, Y., Moriya, T., Maruhashi, A., Omoda, K., Funakoshi, S., Murakami, T. and Takano, M.: Dosage adjustment of ribavirin based on renal function in Japanese patients with chronic hepatitis C. Ther. Drug Monit., 26 (1), 9-15 (2004)$@!!(J
Murakami, T., Sato, A., Inatani, M., Sakurai, H., Yumoto, R., Nagai, J. and Takano, M.: Effect of neonatal exposure of 17b-estradiol and tamoxifen on hepatic CYP3A activity at developmental periods in rats. Drug Metabol. Pharmacokin., 19, 96-102 (2004)
Watanabe, A., Nagai, J., Adachi, Y., Katsube, T., Kitahara, Y., Murakami, T. and Takano, M.: Targeted prevention of renal accumulation and toxicity of gentamicin by aminoglycoside binding receptor antagonists. J. Control. Release, 95, 423-433 (2004)
Yumoto, R., Murakami, T. and Takano, M.: Differential effect of acute hepatic failure on in-vivo and in-vitro P-glycoprotein functions in the intestine. Pharm. Res., 20 (5), 765-771 (2003)
Funakoshi, S., Murakami, T., Yumoto, R., Kiribayashi, Y. and Takano, M.:
Role of P-glycoprotein in pharmacokinetics and drug interactions of digoxin and beta-methyldigoxin in rats. J. Pharm. Sci., 92 (7), 1455-1463 (2003)Nagai, J., Katsube T., Murakami, T. and Takano, M.: Effect of gentamicin on pharmacokinetics of lysozyme in rats: interaction between megalin substrates in the kidney. J. Pharm. Pharmacol., 54, 1491-1496 (2002)
Tsutsumi, Y., Deguchi, T., Takano, M., Takadate, A., W. E. Lindup and Otagiri, M.: Renal disposition of a furan dicarboxylic acid and other uremic toxins in the rat. J. Pharm. Exp. Ther., 303(2), 880-887 (2002)
Yumoto, R. and Takano, M.: Promotion of clinical pharmacy research based on collaboration between university and hospital or community pharmacy -Questionnaire survey of pressent situations and needs-, Jpn. J. Pharm. Health Care Sci., 28(5), 484-488 (2002)
Takano, M., Nakanishi, N., Kitahara, Y., Sasaki, Y., Murakami, T. and Nagai, J: Cisplatin-induced inhibition of receptor-mediated endocytosis of protein in the kidney. Kidney Int., 62, 1707-1717 (2002)
Murakami, T., Fukuda, T., Yumoto, R., Nagai, J., Kuramoto, T. and Takano, M.: Interaction of endogenous compounds in human and rat urine with P-glycoprotein. Drug Metabol. Pharmacokin., 17(3), 245-252 (2002)
Maeda, Y., Funnakoshi, S., Makamura, M., Fukuzawa, M., Kugawa, Y., Yamasaki, M., Tsukiai, S., Murakami, T. and Takano, M.: Possible mechanism for pharmacokinetic interaction between lidocaine and mexiletine. Clin. Pharm. Ther., 71(5), 389-397(2002)
Nagai, J., Tanaka, H., Nakanishi, N., Murakami, T. and Takano, M.: Role of megalin in the renal handling of aminoglycosides. Am. J. Physiol., 281, F337-F344 (2001)
Sasaki, Y., Nagai, J., Kitahara, Y., Takai, N., Murakami, T. and Takano, M.: Expression of chloride channel, ClC-5, and its role in receptor-mediated endocytosis of albumin in OK cells. Biochem. Biophys. Res. Commun., 282(1), 212-218 (2001)
Huang, Z.-H., Murakami, T., Okochi, A., Yumoto, R., Nagai, J. and Takano, M.: Expression and function of P-glycoprotein in rats with carbon tetrachloride-induced acute hepatic failure. J. Pharm. Pharmacol., 53, 873-881 (2001)
Yumoto, R., Murakami, T., Sanemasa, M., Nasu, R., Nagai, J. and Takano, M.: Pharmacokinetic interaction of cytochrome P450 3A-related compounds with rhodamine 123, a P-glycoprotein substrate, in rats pretreated with dexamethasone. Drug Metab. Dispos., 29, 145-151 (2001)
Huang, Z.-H., Murakami, T., Okochi, A., Yumoto, R., Nagai, J. and Takano, M.: Expression and function of P-glycoprotein in rats with glycerol-induced acute renal failure. Eur. J. Pharmacol., 406, 453-460 (2000)
Shiraishi, Y., Nagai, J., Murakami, T. and Takano, M.: Effect of cisplatin on H+ transport by H+-ATPase and Na+/H+ exchanger in rat renal brush-border membrane. Life Sci., 67 (9), 1047-1058 (2000)
Kajikawa, T., Mishima, K. H., Murakami, T. and Takano, M.: Role of P-glycoprotein in ocular clearance of rhodamine 123 in rabbits. Pharm. Res., 17 (4), 479-481 (2000)
Katahira, N., Murakami, T., Kugai, S., Yata, N. and Takano, M.: Enhancement of topical delivery of a lipophilic drug from charged multilamellar liposomes. J. Drug Target., 6 (6), 405-414 (1999)
Higashikawa, F., Murakami, T., Makino, M. and Takano, M.: Hepatic metabolic clearance of midazolam, a cytochrome P-450 3A substrate, in the presence of ketoconazole in rats. Pharm. Pharmacol. Commun., 5, 529-536 (1999)
Higashikawa, F., Murakami, T., Kaneda, T., Kato, A. and Takano, M.: In-vivo and in-vitro metabolic clearance of midazolam, a cytochrome P-450 3A substrate, by the liver under normal and increased enzyme activity in rats. J. Pharm. Pharmacol., 51, 405-410 (1999)
Kajikawa, T., Mishima, K. H., Murakami, T. and Takano, M.: Role of P-glycoprotein in distribution of rhodamine 123 into aqueous humor in rabbits. Curr. Eye Res., 18 (3), 240-246 (1999)
Yumoto, R., Murakami, T., Nakamoto, Y., Hasegawa, R., Nagai, J. and Takano, M.: Transport of rhodamine 123, a P-glycoprotein substrate, across rat intestine and Caco-2 cell monolayers in the presence of cytochrome P450 3A-related compounds. J. Pharmacol. Exp. Ther., 289 (1), 149-155 (1999)
Higashikawa, F., Murakami, T., Kaneda, T., Kato, A. and Takano, M.: Dose-dependent intestinal and hepatic first-pass metabolism of midazolam, a cytochrome P450 3A substrate with differently modulated enzyme activitiy in rats. J. Pharm. Pharmacol., 51, 67-72 (1999)
Hatta, T., Ohmori, H., Murakami, T., Takano, M., Yamashita, K. and Yasuda, M.: Neurotoxic effects of phenytoin on postnatal mouse brain development following neonatal administration. Neurotoxicol. Teratol., 21 (1), 21-28 (1999)
Murakami, T., Sato, M., Higashikawa, F., Okochi, A., Higashi, Y., Yata, N. and Takano, M.: Hepatic clearance of ONO-5046, a novel neutrophil elastase inhibitor, in rats and in the rat perfused liver. J. Pharm. Pharmacol., 50, 425-430 (1998)
Nagai, J., Yano, I., Hashimoto, Y., Takano, M. and Inui, K.: Efflux of intracellular a-ketoglutarate via p-aminohippurate/dicarboxylate exchange in OK kidney epithelial cells. J. Pharmacol. Exp. Ther., 285, 422-427 (1998)
Hashimoto, Y., Murakami, T., Kumasa, C., Higashi, Y., Yata, N. and Takano, M.: In-vivo calibration of microdialysis probe by use of endogenous glucose as an internal recovery marker: measurement of skin distribution of tranilast in rats. J. Pharm. Pharmacol., 50, 621-626 (1998)
Shiraishi, Y., Nagai, J., Kaneyuku, F., Higashi, Y., Murakami, T. and Takano, M.: Renal organic anion secretion and a-ketoglutarate level in rats with chronic metabolic acidosis. Pharm. Pharmacol. Commun., 4 (6), 301-304 (1998)
Yano, I., Takayama, A., Takano, M., Inatani, M., Tanihara, H., Ogura, Y., Honda, Y. and Inui, K.: Pharmacokinetics and pharmacodynamics of acetazolamide in patients with transient intraocular pressure elevation. Eur. J. Clin. Pharmacol., 54 63-68 (1998)
Takano, M., Hasegawa, R., Fukuda, T., Yumoto, R., Nagai, J. and Murakami, T.: Interaction with P-glycoprotein and transport of erythromycin, midazolam and ketoconazole in Caco-2 cells. Eur. J. Pharmacol., 358, 289-294 (1998)
Takami, K., Saito, H., Okuda, M., Takano, M. and Inui, K.: Distinct characteristics of transcellular transport between nicotine and tetraethylammonium in LLC-PK1 cells. J. Pharmacol. Exp. Ther., 286 (2), 676-680 (1998)
Kunihara, M., Nagai, J., Murakami, T. and Takano, M.: Renal excretion of rhodamine 123, a P-glycoprotein substrate, in rats with glycerol-induced acute renal failure. J. Pharm. Pharmacol., 50, 1161-1165 (1998)
Tanaka, K., Hirai, M., Tanigawara, Y., Ueda, K., Takano, M., Hori, R. and Inui, K.: Relationship between expression level of p-glycoprotein and daunorubicin transport in LLC-PK1 cells transfected with human MDR1 gene. Biochem. Pharmacol., 53, 741-746 (1997)
Nakamura, T., Kokuryo, T., Takano, M. and Inui, K.: Renal excretion of vancomycin in rats with acute renal failure. J. Pharm. Pharmacol., 49, 154-157 (1997)
Harada, S., Murakami, T., Higashi, Y., Takano, M. and Yata, N.: Enhancing mechanisms of decanoic acid for the permeation of water-soluble compounds through Caco-2 cell monolayers. Pharm. Sci., 3, 175-178 (1997)
Yano, I., Ito, T., Takano, M. and Inui, K.: Evaluation of renal tubular secretion and reabsorption of levofloxacin in rats. Pharm. Res., 14 (4), 508-511 (1997)
$@LPLZDjG7!"?.2,G5M}!"@8ED5AOB!"B<>e>HIW!"9bLn445W!"LpED!!EP!'%1%m%$%IHn(J $@8|@-am:/<#NE$N8=>u$H%H%i%K%i%9%H$r;HMQ$7$?%$%*%sF3F~K!$K$h$k<#NE7P83!"(J Drug Delivery System 12 (2), 115-120 (1997)
Nagai, J., Yano, I., Hashimoto, Y., Takano, M. and Inui, K.: Inhibition of PAH transport by parathyroid hormone in OK cells: Involvement of protein kinase C pathway. Am. J. Physiol., 273, F674-679 (1997)
Nakamura, T., Takano, M., Yasuhara, M. and Inui, K.: In-vivo clearance study of vancomycin in rats. J. Pharm. Pharmacol., 48, 1197-1200 (1996)
Nabekura, T., Takano, M., Kimura, M., Yasuhara, M. and Inui, K.: Modulation of organic cation transport and lipid fluidity by benzyl alcohol in rat renal brush-border membranes. Pharm. Res., 13 (7), 1077-1080 (1996)
Takano, M., Nagai, J.,Yasuhara, M. and Inui, K.: Regulation of p-aminohippurate transport by protein kinase C in OK kidney epithelial cells. Am. J. Physiol., 271, F469-F475 (1996)
Hashimoto, Y., Otsuki, Y., Odani, A., Takano, M., Hattori, H., Furusho, K. and Inui, K.: Effect of CYP2C polymorphisms on the pharmacokinetics of phenytoin in Japanese patients with epilepsy. Biol. Pharm. Bull., 19(8), 1103-1105 (1996)
Okuda, M., Saito, H., Urakami, Y., Takano, M. and Inui, K.: cDNA cloning and functional expression of a novel rat kidney organic cation transporter, OCT2. Biochem. Biophys. Res. Commun., 224, 500-507 (1996)
Nabekura, T., Takano, M. and Inui, K.: Cholesterol modulates organic cation transport activity and lipid fluidity in rat renal brush-border membranes. Biochim. Biophys. Acta, 1283, 232-236 (1996)
Nabekura, T., Takano, M. and Inui, K.: Effects of benzyl alcohol on organic ion transport in rat renal basolateral membranes. Pharm. Sci., 2, 415-417 (1996)
Nabekura, T., Takano, M. and Inui, K.: Developmental maturation of organic cation transport in rat renal brush-border membranes. Pharm. Sci., 2, 423-425 (1996)
Odani, A., Hashimoto, Y., Takayanagi, K., Otsuki, Y., Koue, T., Takano, M., Yasuhara, M., Hattori, H., Furusho, K. and Inui, K.: Population pharmacokinetics of phenytoin in Japanese patients with epilepsy: Analysis with a dose-dependent clearance model. Biol. Pharm. Bull. 19 (3), 444-448 (1996)
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