Functional Molecular Science - 医薬機能分子科学教室

********* Original Articles (Total Number of Citations = 5273 : 120 articles) ****************
Highly sensitive detection of protein phosphorylation by using improved Phos-tag Biotin,
Proteomics, 12, 932-937 (2012)
E. Kinoshita, E. Kinoshita-Kikuta, Y. Sugiyama, Y. Fukuda, T. Ozeki, and T. Koike

Separation and identification of four distinct serine-phosphorylation states of ovalbumin by Phos-tag affinity electrophoresis,
Electrophoresis, 33, 849-855 (2012)
E. Kinoshita-Kikuta
, E. Kinoshita, and T. Koike

Phos-tag SDS-PAGE systems for phosphorylation profiling of proteins with a wide range of molecular masses under neutral pH conditions,
Proteomics, 12, 192-202 (2012)
E. Kinoshita,
E. Kinoshita-Kikuta, and T. Koike

A Phos-tag-based fluorescence resonance energy transfer system for the analysis of the kinase reaction of a substrate peptide,
Analytical Methods, 3, 1303-1309 (2011),
M. Somura, K. Takiyama, E. Kinoshita-Kikuta, E. Kinoshita, and T. Koike

Zinc(II)–cyclen polyacrylamide gel electrophoresis for detection of mutations in short Ade/Thy-rich DNA fragments,
Analytical Biochemistry, 408, 348-350 (2011),
E. Kinoshita, E. Kinoshita-Kikuta, N. Harada, and T. Koike

Improved Phos-tag SDS-PAGE under neutral pH conditions for advanced protein phosphorylation profiling,
Proteomics, 11, 319-323 (2011),
E. Kinoshita and
E. Kinoshita-Kikuta

A novel phosphate-affinity bead immobilized with Phos-tag for separation and enrichment of phosphopeptides and phosphoproteins,
Journal of Integrated Omics, 1, 157-169 (2011),
E. Kinoshita-Kikuta, A. Yamada, C. Inoue, E. Kinoshita, and T. Koike

Genotyping and mapping assay of single-nucleotide polymorphisms in CYP3A5 using DNA-binding zinc(II) complexes,
Clinical Biochemistry, 43, 302-306 (2010),
E. Kinoshita, E. Kinoshita-Kikuta, H. Nakashima, and T. Koike

Dibridged Bis(zinc(II)-cyclen): A Novel Host Molecule of Malonate Dianion in Aqueous Solution,
Bulletin of the Chemical Society of Japan, 83, 267-272 (2010),
H. Fujioka, S. Kishida, T. Ishizu, M. Shiro, E. Kinoshita, and T. Koike

A clean-up technology for the simultaneous determination of lysophosphatidic acid and sphingosine-1-phosphate by matrix-assisted laser desorption/ionization time-of-flight mass spectrometry using a phosphate-capture molecule, Phos-tag,
Rapid Communications in Mass Spectrometry, 24, 1075-1084 (2010),
J. Morishige, M. Urikura, H. Takagi, K. Hirano, T. Koike, T. Tanaka, and K. Satouchi

The DNA-binding activity of mouse DNA methyltransferase 1 is ragulated phosphorylation with casein kinase 1σ/ε,
Biochemical Journal, 427, 489-497 (2010),
Y. Sugiyama, N. Hatano, N. Sueyoshi, I. Suetake, S. Tajima, E. Kinoshita, E. Kinoshita-Kikuta, T. Koike, and I. Kameshita

Separation and detection of large phosphoproteins using Phos-tag SDS-PAGE,
Nature Protocols, 4, 1513-1521 (2009),
E. Kinoshita, E. Kinoshita-Kikuta, and T. Koike

Mobility shift detection of phosphorylation on large proteins using a Phos-tag SDS-PAGE gel strengthened with agarose,
Proteomics, 9, 4098-4101(2009),
E. Kinoshita, E. Kinoshita-Kikuta, H. Ujihara, and T. Koike

Two-dimensional phosphate affinity gel electrophoresis for the analysis of phosphoprotein isotypes,
Electrophoresis, 30, 550-559 (2009),
E. Kinoshita, E. Kinoshita-Kikuta,
M. Matsubara, Y. Aoki, S. Ohie, Y. Mouri, and T. Koike

Formation of lysophosphatidic acid, a wound-healing lipid, during digestion of cabbage leaves,
Bioscience, Biotechnology, and Biochemistry, 73, 1293-1300 (2009),
T. Tanaka, G. Horiuchi, M. Matsuoka, K. Hirano, A. Tokumura, T. Koike, and K. Satouchi

A Phos-tag-based fluorescence resonance energy transfer system for the analysis of the dephosphorylation of phosphopeptides,
Analytical Biochemistry, 388, 235-241 (2009),
K. Takiyama, E. Kinoshita, E. Kinoshita-Kikuta, Y. Fujioka, Y. Kubo, and T. Koike

Phos-tag beads as an immunoblotting enhancer for selective detection of phosphoproteins in cell lysates,
Analytical Biochemistry, 389, 83-85 (2009),
E. Kinoshita-Kikuta, E. Kinoshita, and T. Koike

Phosphate-affinity Gel Electrophoresis Using a Phos-tag Molecule for Phosphoproteome Study,
Current Proteomics, 6, 104-121 (2009),
E. Kinoshita, E. Kinoshita-Kikuta, and T. Koike

Cytotoxic 16-β-[(D-Xylopyranosyl)oxy]oxohexadecanyl Triterpene Glycosides from a Malagasy Plant, Physena sessiliflora,
Phytochemistry, 70, 1195-1202 (2009),
M. Inoue, K. Ohtani, R. Kasai, M. Okukubo, M. Andriantsiferana, K.Yamasaki, and T. Koike

FANCI phosphorylation functions as a molecular switch to turn on the Fanconi anemia pathway,
Nature Structural & Molecular Biology, 15, 1138-1146 (2008),
M. Ishiai, H. Kitao, A. Smogorzewska, J. Tomida, A. Kinomura, E. Uchida, A. Saberi, E. Kinoshita, E. Kinoshita-Kikuta, T. Koike, S. Tashiro, S. J. Elledge, and M. Takata

An Efficient Identification Method of a Specific Binding Protein for a Bioactive Compound Using On-bead Digestion and Mass Spectrometry,
Bulletin of the Chemical Society of Japan, 81, 1599-1604 (2008),
M. Sakai, M. Fruya, H. Endo, K. Yamaoka, S. Kondo, and T. Koike

Detection of the Gua/Cyt-to-Cyt/Gua mutation in a Gua/Cyt-lined sequence using Zn(II)-cyclen polyacrylamide gel electrophoresis,
Analytical Biochemistry, 380, 122-127 (2008),
E. Kinoshita, E. Kinoshita-Kikuta,
M. Yoshimoto, and T. Koike

Separation of phosphoprotein isotypes having the same number of phosphate groups using phosphate-affinity SDS-PAGE,
Proteomics, 8, 2994-3003 (2008),
E. Kinoshita, E. Kinoshita-Kikuta, M. Matsubara, S. Yamada, H. Nakamura, Y. Shiro, Y. Aoki, K. Okita, and T. Koike


A mobility-shift detection method for DNA methylation analysis using phosphate-affinity polyacrylamide gel electrophoresis,
Analytical Biochemistry, 378, 102-104 (2008),
E. Kinoshita-Kikuta,
E. Kinoshita, and T. Koike

Differential effects of linear and cyclic polyamines on NMDA receptor activities,
Neurochemistry International, 53, 38-44 (2008),
T. Masuko, M. Miyake, K. Kusama-Eguchi, T. Koike, E. Kimura, Y. Kizawa, K. Kashiwagi, K. Igarashi, and T. Kusama


Label-free kinase profiling using phosphate-affinity polyacrylamide gel electrophoresis,
Molecular & Cellular Proteomics, 6, 356-366 (2007),
E. Kinoshita-Kikuta, Y. Aoki, E. Kinoshita, and T. Koike

A single nucleotide polymorphism genotyping method using phosphate-affinity polyacrylamide gel electrophoresis,
Analytical Biochemistry, 361, 294-298 (2007),
E. Kinoshita, E. Kinoshita-Kikuta, and T. Koike

Non-SCN5A Related Brugada Syndromes: Verification of Normal Splicing and Trafficking of SCN5A without Exonic Mutation,
Annals of Human Genetics, 71, 8-17 (2007),
Y. Nakano, S. Tashiro, E. Kinoshita, E. Kinoshita-Kikuta, S. Takenaka, M. Miyoshi, H. Ogi, E. Sakoda, T. Okimoto, Y. Hirai, N. Oda, F. Miura, K. Yamaoka, T. Koike, and K. Chayama

Separation of a phosphorylated-His protein using phosphate-affinity polyacrylamide gel,
Analytical Biochemistry, 360, 160-162 (2007),
S. Yamada, H. Nalkamura, E. Kinoshita, E. Kinoshita-Kikuta, T. Koike, and Y. Shiro

Novel type of phosphate-affinity electrophoresis for protein kinase profiling,
Seibutu Butusurikagaku, 51, 199-206 (2007),
E. Kinoshita, E. Kinoshita-Kikuta, Y. Aoki, and T. Koike

Identification on Membrane and Characterization of Phosphoproteins Using an Alkoxide-Bridged Dinuclear Metal Complex as a Phosphate-Binding Tag Molecule,
Journal of Biomolecular Techniques, 18, 278-286 (2007),
T. Nakanishi, E. Ando, M. Furuta, E. Kinoshita, E. Kikuta-Kinoshita, T. Koike, S. Tsunasawa, and O. Nishimura

Phosphate-binding tag: A new tool to visualize phosphorylated proteins,
Molecular & Cellular Proteomics, 5, 749-757 (2006),
E. Kinoshita, E. Kinoshita-Kikuta, K. Takiyama, and T. Koike

Enrichment of phosphorylated proteins from cell lysate using phosphate-affinity chromatography at physiological pH,
Proteomics, 6, 5088-5095 (2006),
E. Kinoshita-Kikuta, E. Kinoshita, A. Yamada, M. Endo, and T. Koike

Reliable and Cost-effective Screening of Inherited Heterozygosity by Using Zn(II)-Cyclen Polyacrylamide Gel Electrophoresis,
Clinical Chemistry, 51, 2195-2198 (2005),
E. Kinoshita, E. Kinoshita-Kikuta, H. Kojima, Y. Nakano, K. Chayama, and T. Koike

Detection and Quantification of On-Chip Phosphorylated Peptides by Surface Plasmon Resonance Imaging Techniques Using a Phosphate Capture Molecule,
Analytical Chemistry, 77, 3979-3985 (2005),
K. Inamori, M. Kyo, Y. Nishiya, Y. Inoue, T. Sonoda, E. Kinoshita, T. Koike, and Y. Katayama


A heteroduplex-preferential Tm depressor for the specificity-enhanced DNA polymerase chain reaction,
Analytical Biochemistry, 337, 154-160 (2005),
E. Kinoshita, E. Kinoshita-Kikuta, and T. Koike


Novel immobilized zinc(II) affinity chromatography for phosphopeptides and phosphorylated proteins,
Journal of Separation Science, 28, 155-162 (2005),
E. Kinoshita, A. Yamada, H. Takeda, E. Kinoshita-Kikuta, and T. Koike

An Alkoxide-bridged Dinuclear Zinc(II) Hexaazacryptate: a Novel Phosphate Capture Molecule in Aqueous Solution,
Bulletin of the Chemical Society of Japan, 78, 125-131 (2005),
E. Kinoshita, K. Ishikawa, E. Kinoshita-Kikuta, K. Ohtani, M. Shiro, and T. Koike

Recognition of phosphate monoester dianion by an alkoxide-bridged dinuclear zinc(II) complex,
Dalton Transactions, 1189-1193 (2004),

E. Kinoshita, M. Takahashi, H. Takeda, M. Shiro, and T. Koike

Inhibition of NADPH-dependent enzyme activities using the dinuclear zinc chelate, Phos-tag, and reactivation depending on phosphate ion concentrations,
Journal of Analytical Bio-Science, 27, 224-248 (2004),
Y. Nishiya, K. Tsuji, and T. Koike

Quantitative analysis of lysophosphatidic acid by time-of-flight mass spectrometry using a phosphate capture molecule,
Journal of Lipid Research, 45, 2145-2150 (2004),

T. Tanaka, H. Tsutsui, K. Hirano, T. Koike, A. Tokumura, and K. Satouchi

Production of 1,2-Didocosahexaenoyl Phosphatidylcholine by Bonito Muscle Lysophosphatidylcholine/Transacylase,
Journal of Biochemistry, 136, 477-483 (2004),

K. Hirano, H. Matsui, T. Tanaka, F. Matsuura, K. Satouchi, and T. Koike

A macrocyclic zinc(II) fluorophore as a detector of apoptosis,
Proc. Natl. Acad. Sci. USA, 100, 3731-3736 (2003),

E. Kimura, S. Aoki, E. Kikuta, and T. Koike

A Novel Antibacterial 8-Chloroquinoline with a Distorted Orientation of N1-(5-Amino-2,4-difluorophenyl) Group,
Journal of Medicinal Chemistry, 46, 1905-1917 (2003),
Y. Kuramoto, Y. Ohshita, J. Yoshida, A. Yazaki, M. Shiro, and T. Koike

Computer-aided design of a factor Xa inhibitor by using MCSS functionality maps and a CAVEAT linker search,
Journal of Molecular Graphics and Modeling, 22, 105-114 (2003),
Y. Takano, M. Koizumi, R. Takarada, M. Kaminuma-Takimoto, R. Czerminski, and T. Koike

Matrix-assisted laser desorption/ionization time-of-flight mass spectrometry of phosphorylated compounds using a novel phosphate capture molecule,
Rapid Communications in Mass Spectrometry, 17, 2075-2081 (2003),
H. Takeda, A. Kawasaki, M. Takahashi, A. Yamada, and T. Koike

A novel procedure for simple and efficient genotyping of single nucleotide polymorphisms by using Zn(II)-cyclen complex,
Nucleic Acids Research, 30, e126(1-6) (2002),
E. Kinoshita-Kikuta, E. Kinoshita, and T. Koike

Synthesis and characterization of the zinc(II)-fluorophore, 5-dimethylamino naphthalene-1-sulfonic acid [2-(1,5,9-triazacyclododec-1-yl)-ethyl]-amide and its zinc(II) complex,
J. Chem. Soc., Dalton Transactions, 1764-1768 (2002),
T. Koike, T. Abe, M. Takahashi, K. Ohtani, E. Kimura, and M. Shiro

A Novel Prokaryotic Phospholipase A2: Characterization, Gene Cloning, and Solution Structure,
Journal of Biological Chemistry, 277, 20051-20058 (2002),
M. Sugiyama, K. Ohtani, M. Izuhara, T. Koike, K. Suzuki, S. Imamura, and H. Misaki

The Construction of The Latest Medicinal Information Service System in Medical Field,
Japanese Journal of Drug Imaformatics, 4, 67-73 (2002),
K. Ohtani, M. Takahashi, and T. Koike

Streptomyces Phospholipase A2: Its Use in the Enzymatic Measurement of Calcium(II) Ion Content,
Actinomycetologica, 16, 17-20 (2002),
M. Sugiyama, T. Koike, T. Kumagai, Y. Matoba, and S. Imamura

Effects of bis(aromatic) pendants on recognition of nucleobase thymine by zinc(II)-1,4,7,10-tetraazacyclododecane,
Supramolecular Chemistry, 14, 95-102 (2002),
E. Kimura, N. Katsube, T. Koike, M. Shiro, and S. Aoki

Novel mechanism of blocking Na channels in squid axon by three macrocyclic polyamine analogues and two spider toxins,
British Journal of Pharmcology, 132, 63-72 (2001),
M. Yakehiro, Y. Furukawa, T. Koike, E. Kimura, T. Nakajima, K. Yamaoka, and I. Seyama

Controlling Gene Expression by Zinc(II)-Macrocycic Tetraamine Complexes,
Journal of Inorganic Biochemistry, 79, 253-259 (2000),
E. Kikuta, T. Koike, and E. Kimura

Three-Dimensional Supermolecules Assembled from a Tris(Zn-cyclen) Complex and Di- and Tri-anionic Cyanuric Acid in Aqueous Solution,
Journal of The American Chemical Society, 122, 576-584 (2000),
S. Aoki, M. Shiro, T. Koike, and E. Kimura

Elaboration of Selective and Efficient Recognition of Thymine Base in Dinucleotides, Single-stranded and Double-stranded DNA by Acridinylcyclen,
Journal of The American Chemical Society, 122, 4668-4677 (2000),
E. Kimura, H. Kitamura, K. Ohtani, and T. Koike

Selective Recognition of Consecutive G Sequence in Double-Stranded DNA by Zinc(II)-Macrocycic Tetraamine Complex Appended with an Anthraquinone,
Journal of Inorganic Biochemistry, 82, 239-249 (2000),
E. Kikuta, R. Matsubara, N. Katsube, T. Koike, and E. Kimura

Dynamic Enolate Recognition in Aqueous Solution by Zinc(II) in a Phenacyl-pendant Cyclen Complex: Implications for the Role of Zinc(II) in Class II Aldolases,
Journal of The American Chemical Society, 121, 1267-1274 (1999),
E. Kimura, T. Gotoh, T. Koike, and M. Shiro

Novel Recognition of Thymine Base in Double-Stranded DNA by Zinc(II)-Macrocyclic Tetraamine Complexes Appended with Aromatic Groups,
Journal of The American Chemical Society, 121, 5426-5436 (1999),
E. Kikuta, M. Murata, N. Katsube, T. Koike, and E. Kimura

Selective and Efficient Recognition of Thymidylylthymidine (TpT) by Bis(Zn-cyclen) and Thymidylylthymidylylthymidine (TpTpT) by Tris(Zn-cyclen),
Chemistry, A Europian Journal, 5, 3113-3123 (1999),
E. Kimura, M. Kikuchi, H. Kitamura, and T. Koike

A new macrocyclic tetraamine, 2,4-dinitrophenylcyclen: synthesis, cation reporter properties, and recognition of 1-methylthymine by its zinc(II) complex,
Inorganica Chimica Acta, 270, 424-432 (1998),
T. Koike, T. Gotoh, S. Aoki, E. Kimura, and M. Shiro

Structure and O2-uptake Properties of a Novel Ni(II) Complex of Pyridyl-pendant dioxocyclam,
Journal of Biological and Inorgorganic Chemistry, 2, 74-82 (1997),
E. Kimura, M. Sasada, M. Shionoya, T. Koike, H. Kurosaki, and M. Shiro

A Tris(Zinc(II)-1,4,7,10-tetraazacyclododecane) Complex as a New Receptor for Phosphate Dianions in Aqueous Solution,
Journal of The American Chemical Society, 119, 3068-3076 (1997),
E. Kimura, S. Aoki, T. Koike, and M. Shiro

Facile and Selective, Electrostatic Stabilization of Uracil N(1)-Anion by a Proximate Protonated Amine: A Chemical Implication for Why Uracile N(1) is Chosen for Glycocylation Site,
Journal of The American Chemical Society, 119, 10909-10919 (1997),
E. Kimura, H. Kitamura, T. Koike, and M. Shiro

A New Bis(zinc(II)-cyclen) Complex as A Novel Chelator for Barbiturates and Phosphates,
Heterocycles, 42, 775-787 (1996),
H. Fujioka, T. Koike, N. Yamada, and E. Kimura

A New Cyclam with a Triphenylphosphine-pendant and Its Metal Complexes,
Inorganica Chimica Acta, 246, 151-158 (1996),
E. Kimura, Y. Kodama, M. Shionoya, and T. Koike

Novel Properties of Cooperative Dinuclear Zinc(II) Ions: The Selective Recognition of Phosphomonoester and Their P-O Ester Bond Cleavage by New Dinuclear Zinc(II) Cryptate,
Journal of The American Chemical Society, 118, 3091-3099 (1996),
T. Koike, M. Inoue, E. Kimura, and M. Shiro

Bis-(zinc(II)-cyclen) Complex as a Novel Receptor of Barbiturates in Aqueous Solution,
Chemistry, A Europian Journal, 2, 617-623 (1996),
T. Koike, M. Takashige, E. Kimura, H. Fujioka, and M. Shiro

Differntial Contribution of Metal Complexation and Dimerization to the Chemotherapeutic Potential of Bicyclen-Zinc(II) Complex against Human Immunodeficiency Virus,
Biological Pharmaceutical Bulletin, 19, 456-458 (1996),
Y. Inoue, T. Kanamori, T. Yoshida, T. Koike, M. Shionoya, H. Fujioka, and E. Kimura

Hydrolysis of Lophophilic Esters Catalyzed by a Zinc(II) Complex of a Long Alkyl-pendant Macrocyclic Teteramine in Micellar Solution,
Journal of The American Chemical Society, 118, 10963-10970 (1996),
E. Kimura, H. Hashimoto, and T. Koike

A Novel Biomimetic Zinc(II)-fluorophore, Dansylamidoethyl-pendant Cyclen,
Journal of The American Chemical Society, 118, 12696-12703 (1996),
T. Koike, T. Watanabe, S. Aoki, E. Kimura, and M. Shiro

The Catalytic Carboxyester Hydrolysis by a New Zinc(II) Complex with an Alcohol-Pendant Cyclen (1-(2-Hydroxyethyl)-1,4,7,10-tetraazacyclododecane): A Novel Model for Indirect Activation of the Serine Nucleophile by Zinc(II) in Zinc Enzymes,
Journal of The American Chemical Society, 117, 1210-1219 (1995),
T. Koike, S. Kajitani, I. Nakamura, E. Kimura, and M. Shiro

Formation Equilibrium of a Copper(II)-binuclear Complex of a New Pyridyl-containing Tetraoxo Octaaza Macrocyclic Ligand,
Bulletin of the Chemical Society of Japan, 1627-1633 (1995),
M. Kodama, T. Koike, and E. Kimura

Phosphodiester Hydrolysis by a New Zinc(II) Macrocyclic Tetraamine Complex with an Alcohol Pendant: Elucidation of the Role of Ser-102 and Zinc(II) in Alkaline Phosphatase,
Journal of The American Chemical Society, 117, 8304-8311 (1995)
E. Kimura, Y. Kodama, T. Koike, and M. Shiro

A Zinc(II)-cyclone Complex Attached to an Anthraquinone Moiety that Acts as a Redox-active Nucleobase Receptor in Aqueous Solution,
Bulletin of The Chemical Society of Japan, 2465-2469 (1995),
J. H. R. Tucker, M. Shionoya, T. Koike, and E. Kimura

Dimeric Macrocyclic Polyamine with Potent Inhibitory Activity against Human Immunodeficiency Virus,
Aniviral Chemistry & Chemotherapy, 6, 337-344 (1995),
Y. Inoue, T. Kanamori, M. Sugiyama, T. Yoshida, T. Koike, M. Shionoya, K. Enomoto, K. Suehiro, and E. Kimura

Inhibition of Human Immunodeficiency Virus Type 1 (HIV-1) Replication by Macrocyclic Polyamines and Their Metal Complexes,
Biological and Pharmaceutical Bulletin, 17, 243-250 (1994),
Y. Inoue, T. Kanamori, T. Yoshida, B. Xianhe, M. Shionoya, T. Koike, and E. Kimura

Carboxyester Hydrolysis Promoted by a New Zinc(II) Macrocyclic Triamine Complex with an Alkoxide-pendant: A Model Study for the Serine Alkoxide Nucleophile in Zinc Enzyme,
Journal of The American Chemical Society, 116, 4764-4771 (1994),
E. Kimura, I. Nakamura, T. Koike, M. Shionoya, Y. Kodama, T. Ikeda, and M. Shiro

Role of Zinc(II) in β-Lactamase II: A Model Study with a Zinc(II)-Macrocyclic Tetraamine (1,4,7,10-Tetraazacyclododecane, Cyclen) Complex,
Journal of The American Chemical Society, 116, 8443-8449 (1994),
T. Koike, M. Takamura, and E. Kimura

Chemical Sensing Based on Membrane Potential Change Induced by Host-Guest Complexation at Membrane Surface,
Supramolecular Chemistry, 4, 101-113 (1994),
K. Odashima, R. Naganawa, H. Radecka, M. Kataoka, E. Kimura, T. Koike, K. Tohda, M. Tange, H. Furuta, J. L. Sessler, K. Yagi, and Y. Umezawa

The Gold(III)-cyclam Complexes: X-ray Crystal Structure and a Useful Macrocyclic Effect on Reduction of Gold(III) for Development of New Gold Metal Plating,
Journal of Coordination Chemistry, 28,33-49 (1993),
E. Kimura, Y. Kurogi, T. Koike, M. Shionoya, and Y. Iitaka

Novel Bifunctional Macrocyclic Chelating Agents Appended with a Pendant-Type Carboxymethylamino Ligand and Nitrobenzyl Group and Stability of the Y(III) Complexes,
The Journal of Organic Chemistry, 58, 1955-1958 (1993),
K. Takenouchi, K. Watanabe, Y. Kato, T. Koike, and E. Kimura

A New Cyclam with an NH2-Pendant Donor, 6-Amino-1,4,8,11-tetraazacyclotetradecane, and Its Nickel(II) Complexes,
Inorganic Chemistry, 32, 2779-2784 (1993),
E. Kimura, M. Haruta, T. Koike, M. Shionoya, K. Takenouchi, and Y. Iitaka

Kinetics and Mechanism of the Hydration of CO2 and Dehydration of HCO3- Catalyzed by a Zn(II) Complex of 1,5,9-Triazacyclododecane as a Model for Carbonic Anhydrase,
Inorganic Chemistry, 32, 5749-5755 (1993),
X. Zhang, R. van Eldik, T. Koike, and E. Kimura

Novel Pendant-type Macrocyclic Bifunctional Chelating Agents: Carboxymethylamino Derivatives of 2-(4-Nitrobenzyl)-1,4,7,10-tetraazacyclododecane-N,N',N"",N'''-tetraaxetic Acid and Their Complex Formation with Yttrium(III),
The Journal of Organic Chemistry, 58, 6895-6899 (1993),
K. Takenouchi, M. Tabe, K. Watanabe, A. Hazato, Y. Kato, M. Shionoya, T. Koike, and E. Kimura

Potentiometric Discrimination between Planar and Octahedral Anionic Metal Cyano Complexes by Liquid Membranea Electrodes Based on Lipophilic Macrocyclic Dioxopolyamines,
Electroanalysis, 5, 731-738 (1993),
R. Naganawa, H. Redecka, M. Kataoka, K. Tohda, K. Odashima, Y. Umezawa, E. Kimura, and T. Koike

X-ray structural Study of Zinc(II) Inclusion Complex of a Phenolate-Pendant Cyclam,
Journal of Inclusion Phenomena Molecular Recognition in Chemistry, 12, 377-378 (1992),
E. Kimura, H. Kurosaki, T. Koike, and K. Toriumi

A Versatile Macrocyclic [12]aneN3 for Interconversion of Tetrahedral and Trigonal Bipyramidal Zinc(II) Complexes: Relevance to Four- and 5-Coordinate Geometries of Zinc(II) in Carbonic Anhydrase,
Chemistry Letters, 787-790 (1992),
E. Kimura, T. Koike, M. Shionoya, and M. Shiro

The First Anionic Sulfonamide-Binding Zinc(II) Complexes with a Macrocyclic Triamine: Chemical Verification of the Sulfonamide Inhibition of Carbonic Anhydrase,
Journal of The American Chemical Society, 114, 7338-7345 (1992),
T. Koike, E. Kimura, I. Nakamura, Y. Hashimoto, and M. Shiro

Role of Substituents in Copper(II) Extraction with N,N""-Bis(8-quinolyl)malonamides,
The Journal of The Chemical Society, Dalton Transactions, 2679-2683 (1992),
T. Hirose, K. Hiratani, K. Kasuga, K. Saito, T. Koike, E. Kimura, Y. Nagawa, and H. Nakanishi

Thermodynamic and Kinetic Studies of Lanthanide Complexes of 1,4,7,10,13-Pentaaza-cyclopentadecane-N,N',N"",N'"",N""""-pentaacetic Acid and 1,4,7,10,13,16-Hexaazacyclo-octadecane-N,N',N"",N""',N"""",N""""'-Hexaacetic Acid,
Inorganic Chemistry, 30, 1270-1273 (1991),
M. Kodama, T. Koike, A. B. Mahatma, and E. Kimura

Roles of Zinc(II) Ion in Phosphatases. A Model Study with Zinc(II)-Macrocyclic Polyamine Complexes,
Journal of The American Chemical Society, 113, 8935-8941 (1991),
T. Koike and E. Kimura

A Study of New Bis(macrocyclic polyamine) Ligands as Inorganic and Organic Anion Recepters,
The Journal of Organic Chemistry, 55, 42-46 (1990),
E. Kimura, Y. Kuramoto, T. Koike, H. Fujioka, and M. Kodama

Comparison of Potentiometric Responce Behavior of Liquid Membranes incorpotrated with N4 and N5 Lipophilic Macrocyclic Polyamines,
Bunseki Kagaku, 39, 671-676 (1990),
R. Naganawa, M. Kataoka, K. Odashima, Y. Umezawa, E. Kimura, and T. Koike

A Novel Cyclam Appended with 3-Hydroxypyridine. An Ambident Donor Ligand Comprising a Pyridyl N and a Pyridinolate O-Donors,
Inorganic Chemistry, 29, 4991-4996 (1990),
E. Kimura, Y. Kotake, T. Koike, M. Shionoya, and M. Shiro

Polarographic Study of the Rates of the Dissociation Reactions of the Eu(III)-HAHA Complex and of the Eu(III)-, Gd(III)-, and Ho(III)- PAPA Complexes,
Bulletin of the Chemical Society of Japan, 63, 2639-2645 (1990),
M. Kodama, A. B. Mahatma, T. Koike, and E. Kimura

The Electrochemical Study of Ag(II) Complexes of Polyaza Macrocycles and their Acetic Acid Derivatives,
Bulletin of the Chemical Society of Japan, 63, 2803-2808 (1990),
M. Kodama, A. B. Mahatma, T. Koike, and E. Kimura

A Zinc(II) Complex of 1,5,9,-Triazacyclododecane ([12]aneN3) as a Model for Carbonic Anhydrase,
Journal of The American Chemical Society, 112, 5805-5811 (1990),
E. Kimura, T. Shiota, T. Koike, M. Shiro, and M. Kodama

Acid Properties of Zn(II) and Cd(II) in Complexation with Macrocyclic Oxo Polyamine Ligands,
Inorganic Chemistry, 29, 4621-4629 (1990),
E. Kimura, T. Koike, T. Shiota, and Y. Iitaka

A Convenient Synthesis of a Macrocyclic Dioxo Pentaamine and X-ray Crystal Structure of Its Monohydrazoic Acid Salt,
The Journal of Organic Chemistry, 54, 3998-4000 (1989),
E. Kimura, H. Anan, T. Koike, and M. Shiro

A Copper(I) N,N,N',N"",N""-Pentamethyldiethylenetriamine Complex and Its Carbon Monoxide Adduct in Aqueous Solutions,
Inorganic Chemistry, 28, 2998-3001 (1989),
E. Kimura, T. Koike, M. Kodama, and D. Meyerstein

Complexation Reactions of Copper(II) Ions with 16-Membered and 18-Membered Monocyclic Dioxopolyamines in an Aqueous Solution,
Bulletin of the Chemical Society of Japan, 62, 4044-4046 (1989),
M. Kodama, H. Anan, T. Koike, and E. Kimura

Potentiometric Liquid Membrane Sensors That Discriminate Linear Homologs and Geometrical/Positional Isomers of Dicarboxylates,
Analytical Letters, 22, 1089-1105 (1989),
M. Kataoka, R. Naganawa, K. Odasima, Y. Umezawa, E. Kimura, and T. Koike

A Trigonal Bipyramidal Zinc(II) Complex of Phenol-pendant Macrocyclic Triamine,
Inorganic Chemistry, 27, 3687-3688 (1988),
E. Kimura, T. Koike, and K. Toriumi

First X-Ray Crystal Structures of Nickel(II)-Oxocyclam Complexes: Effects of the Deprotonated Amide and of an Intramolecular Pendant Pyridine on the Cyclam Ligand Field,
Inorganic Chemistry, 27, 1036-1040 (1988),
E. Kimura, T. Koike, H. Nada, and Y. Iitaka

Potentiometric Adenosine Triphosphate Polyanion Sensor Using a Lipophilic Macrocyclic Polyamine Liquid Membrane,
Analytical Chemistry, 60, 2392-2396 (1988),
Y. Umezawa, M. Kataoka, W. Takami, E. Kimura, T. Koike, and H. Nada

The o-Methoxyphenol-Pendant Cyclam Complexes: A Novel Molecule Designed for Intramolecular Redox Coupling between Monodentate Catecholate and Metal Ions in an N4 Macrocycle,
Journal of The American Chemical Society, 109, 5528-5529 (1987),
E. Kimura, S. Joko, T. Koike, and M. Kodama

New-Dimensional Cyclam: Synthesis, Crystal Structure, and Chemical Properties of Macrocyclic Tetraamines Bearing a Phenol Pendant,
Inorganic Chemistry, 26, 2975-2983 (1987),
E. Kimura, T. Koike, K. Uenishi, M. Hediger, M. Kuramoto, S. Joko, Y. Arai, M. Kodama, and Y. Iitaka

A New Mg(II) Ion Receptor: Macrocyclic Polyamines Bearing an Intraannular Phenolic Group,
Journal of The American Chemical Society, 109, 6212-6213 (1987),
E. Kimura, Y. Kimura, T. Yatsunami, M. Shionoya, and T. Koike

A potent superoxide dismutase-like activity by cimetidine-copper complex,
Free Radicals in Clinical Medicine, 1, 79-81 (1987) ,
E. Kimura and T. Koike

Molecular Structure of a Nickel(II) Complex with Phenolate-Appended Cyclam,
Inorganic Chemistry, 25, 402-404 (1986),
E. Kimura, T. Koike, and Y. Iitaka

Complexes of the Histamine H2-Antagonist Cimetidine with Divalent and Monovalent Copper Ions,
Inorganic Chemistry, 25, 2242-2246 (1986),
E. Kimura, T. Koike, Y. Shimizu, and M. Kodama

Crystal and Solution Structures of Nickel(II)-13-Membered Macrocyclic Tetramine [1,4,7,10-Tetraazacyclotridecanenickel(II)] Effected by a Pendant Phenol,
Chemistry Letters, 1137-1140 (1986),
E. Kimura, K. Uenishi, T. Koike, and Y. Iitaka

Novel Electrochemical Behaviour of a Nickel(II)-13-Membered Macrocyclic Tetra-amine effected by a Pendant Phenol,
J. C. S. Chemical Communications, 1110-1111 (1986),
E. Kimura, T. Koike, K. Uenishi, and R. B. Davidson

A New Cyclam providing the First Example Unequivocally Proven by X-Ray Crystallography of a Pendent Co-ordinated Pyridyl Group,
J. C. S. Chemical Communications, 1322-1323 (1986),
E. Kimura, T. Koike, H. Nada, and Y. Iitaka

Synthesis and Metal Complexes of Macrocyclic Triamines Bearing a Phenol Pendant,
Inorganic Chemistry, 25, 3883-3886 (1986),
E. Kimura, M. Yamaoka, M. Morioka, and T. Koike

Novel Synthesis and Complex Properties of Macrocyclic Tetraamines Appended with Phenol as an Axial Donor,
J. C. S. Chemical Communications, 385-386 (1985),
E. Kimura, T. Koike, and M. Takahashi

Rapid Oxidative Metal Insertion into a Macrocyclic Ring from a 'Metal-out' Position and Identification of a Stable 'Metal-in' Isomer of a Ni(II)-Cyclamtetra-acetate Complex,
J. C. S. Chemical Communications, 1341-1343 (1985),
E. Kimura, T. Koike, M. Yamaoka, and M. Kodama

Metal Chelates of Sulphur-containing Polyamine Macrocycles and Oxygenation of the Corresponding Cobalt(II) Complexes,
J. C. S. Dalton Transactions, 673-678 (1984),
M. Kodama, T. Koike, N. Hoshiga, R. Machida, and E. Kimura

Effects of Imide Anions and Axial Donors on the Stability and Oxidation Behavior of Square Planar 13-15-Membered Macrocyclic Tetraamine Complexes of Nickel(II) and Copper(II),
Inorganic Chemistry, 23, 4181-4188 (1984),
E. Kimura, T. Koike, R. Machida, R. Nagai, and M. Kodama

Macrocyclic Polyamines as a Possible Chemical Model for Histamine H2-Receptors,
Chemical and Pharmaceutical Bulletin, 32, 3569-3578 (1984),
E. Kimura, T. Koike, and M. Kodama

Further Studies on Superoxide Dismutase Activities of Macrocyclic Polyamine Complexes of Copper(II),
Biochimica Biophysica Acta, 745, 37-43 (1983),
E. Kimura, A. Yatsunami, A. Watanabe, R. Machida, T. Koike, H. Fujioka, Y. Kuramoto, M. Sumomogi, K. Kunimitsu, and A. Yamashita