秋研@広大生命研

研究内容 ｜ メンバー ｜ 論文・著書 ｜ 講演 ｜ 特許 ｜ 外部資金

 

Takuro Nakagawa, Tetsuya Miyamoto, Shouhei Miki, Kenshi Watanabe, Tsunehiro Aki, Hiroyuki Shidara, Hideyuki Yamashita (2023) Preparation of egg-koji for developing a novel food. J. Biosci. Biotechnol., 135, 447-450

Kimberly D. Neri, Mark Kevin P. Devanadera, Kenshi Watanabe, Reuel M. Bennett, Kim Hazel V. Arafiles, Tsunehiro Aki, Gina R. Dedeles (2023) Fatty Acid Profiles of Oomycetes (Halophytophthora and Phytopythium spp.) from Philippine Mangroves. Lett. Appl. Microbiol., 76, ovad022

Yoshiko Okamura, Ryo Shimizu, Yoriko Tominaga, Sachiko Maki, Tsunehiro Aki, Yukihiko Matsumura, Yutaka Nakashimada (2023) Characterization of biogenic PbS quantum dots. Int. J. Mol. Sci., 24, 14149

Hiroto Maeda, Yuto Hirata, Hirokazu Takahashi, Kenshi Watanabe, Tsunehiro Aki, Yoshiko Okamura (2023) Development of a transformation system for Nitratireductor sp. Mar. Biotechnol., 25, 644-651

秋　庸裕 (2023) 微生物油脂．新基礎講座 第14回脂質．オレオサイエンス23: 456-459

K. Watanabe, M. Nishijima, S. Mayuzumi, T. Aki (2022) Utilization of sugarcane bagasse as a substrate for lipid production by Aurantiochytrium sp. J. Oleo Sci., 71, 1493-1500

渡邉研志、秋　庸裕 (2022) 微生物による二酸化炭素固定と利用、pp. 97-102（分担執筆）、二酸化炭素利活用技術、情報機構

K. Horio, H. Takahashi, T. Kobori, K. Watanabe, T. Aki, Y. Nakashimada, Y. Okamura (2021) Visualization of gene reciprocity among lactic acid bacteria in yogurt by RNase H-assisted rolling circle amplification-fluorescence in situ hybridization. Microorganisms, 9, 1208.

K. Watanabe, C.M.T. Perez, T. Kitahori, K. Hata, M. Aoi, H. Takahashi, T. Sakuma, Y. Okamura, Y. Nakashimada, T. Yamamoto, K. Matsuyama, S. Mayuzumi, T. Aki (2021) Improvement of fatty acid productivity of thraustochytrid, Aurantiochytrium sp. by genome editing. J. Biosci. Bioeng., 131, 373-380

渡邉研志、秋　庸裕 (2021) オーランチオキトリウムによるバイオリファイナリーと有用脂質生産、pp. 118-122（分担執筆）、バイオエネルギー再燃、植田充美監修、シーエムシー出版

H. Takahashi, K. Horio, S. Kato, T. Kobori, K. Watanabe, T. Aki, Y. Nakashimada, Y. Okamura (2020) Direct detection of mRNA expression in microbial cells by fluorescence in situ hybridization using RNase H-assisted rolling circle amplification. Sci. Rep., 10, 9588

渡邉研志、秋　庸裕 (2020) バイオリファイナリーによる未利用資源や産業廃棄物からの有用脂質生産．オレオサイエンス20: 119-124

渡邉研志、秋　庸裕 (2020) オーランチオキトリウム属を活用したバイオリファイナリーによる有用脂質生産．生物工学会誌98: 472-476

※経産省・資源エネルギー庁・カーボンリサイクル技術事例集「カーボンリサイクルを実現するGas-to-Lipidsバイオプロセスの開発」（リンク先）（2020.1.7）

N.A.L.E. Caguimbal, M.K.P. Devanadera, R.M. Bennett, K.H.V. Arafiles, K. Watanabe, T. Aki, G.R. Dedeles (2019) Growth and fatty acid profiles of Halophytophthora vesicula and Salispina spinosa from Philippine mangrove leaves. Lett. Appl. Microbiol., 69, 221-228

Y. Okamura, L. Treu, S. Campanaro, S. Yamashita, S. Nakai, H. Takahashi, K. Watanabe, I. Angelidaki, T. Aki, Y. Matsumura, Y. Nakashimada (2019) Complete genome sequence of Nitratireductor sp. strain OM-1: A lipid-producing bacterium with potential use in wastewater treatment. Biotechnol. Rep., 24, e00366

M.K.P. Devanadera, R.M. Bennett, K. Watanabe, M.R. Santiago, M.C. Ramos, T. Aki, G.R. Dedeles (2019) Marine oomycetes (Halophytophthora and Salispina): A potential source of fatty acids with cytotoxic activity against breast adenocarcinoma cells (MCF7). J. Oleo Sci., 68, 1163-1174.

C.M.T. Perez, K. Watanabe, Y. Okamura, Y. Nakashimada, T. Aki (2019) Metabolite profile analysis of Aurantiochytrium limacinum SR21 grown on acetate-based medium for lipid fermentation. J. Oleo Sci., 68, 541-549.

※日経バイオテクONLINE記事「ゲノム編集で海洋微生物の脂質を改質」（2019.9.10）

★原著論文の被引用数が合計2000回を越えました（>Scopus）

K.G. El Ramlawy, T. Fujimura, T. Aki, A. Okada, T. Suzuki, T. Abe, T. Hayashi, M.J. Epton, W.R. Thomas, I.H. Rafeet, D.B. Al-Azhary, K. Ono, S. Kawamoto (2018) Prominent IgE-binding and cytokine-inducing capacities of a newly cloned N-terminal region of Der f 14, an apolipophorin-like house dust mite allergen. J. Biochem., 163, 51-60

Okamura Y., Nakai S., Takahashi H., Miura T., Tajima T., Aki T., Matsumura Y., Nakashimada Y. (2018) Potential of Nitratireductor sp. OM-1 to produce more short-chain esters and less excess sludge during wastewater treatment. European Biomass Conference and Exhibition Proceedings, 2018, 26thEUBCE, pp. 917-920

H. Takahashi, M. Ohkawachi, K. Horio, T. Kobori, T. Aki, Y. Matsumura, Y. Nakashimada, Y. Okamura (2018) RNase H-assisted RNA-primed rolling circle amplification for targeted RNA sequence detection. Sci. Rep., 8, 7770

K. Watanabe, K.H.V. Arafiles, R. Higashi, Y. Okamura, T. Tajima, Y. Matsumura, Y. Nakashimada, K. Matsuyama, T. Aki (2018) Isolation of high carotenoid-producing Aurantiochytrium sp. mutants and improvement of astaxanthin productivity using metabolic information. J. Oleo Sci., 67, 571-578

H. Iwasaka, R. Koyanagi, R. Satoh, A. Nagano, K. Watanabe, K. Hisata, N. Satoh, T. Aki (2018) A possible trifunctional beta-carotene synthase gene identified in the draft genome of Aurantiochytrium sp. strain KH105. Genes, 9, 200

T. Tajima, K. Tomita, H. Miyahara, K. Watanabe, T. Aki, Y. Okamura, Y. Matsumura, Y. Nakashimada, J. Kato (2018) Efficient conversion of mannitol derived from brown seaweed to fructose for fermentation with a thraustochytrid, J. Biosci. Bioeng., 125, 180-184

T. Miura, A. Kita, Y. Okamura, T. Aki, Y. Matsumura, T. Tajima, J. Kato, Y. Nakashimada (2017) Improved methanization and microbial diversity during batch mode cultivation with repetition of substrate addition using defined organic matter and marine sediment inoculum at seawater salinity. Bioresour. Technol., 245, 833-840

P. Duangkaew, S. Inoue, T. Aki, Y. Nakashimada, Y. Okamura, T. Tajima, Y. Matsumura (2017) Quantitative in situ mass spectrometry analysis of mannitol decomposition products under hydrothermal conditions. Energy Fuels, 31, 10866-10873

P. Duangkaew, S. Inoue, T. Aki, Y. Nakashimada, Y. Okamura, T. Tajima, Y. Matsumura (2017) Real-time Mass Spectrometric Analysis of Hydrothermal Reaction Products. Ind. Eng. Chem. Res., 56, 9993-9998

P. Duangkaew, S. Inoue, T. Aki, Y. Nakashimada, Y. Okamura, T. Tajima, Y. Matsumura (2017) In situ mass spectrometry of glucose decomposition under hydrothermal reactions, Korean J. Chem. Eng., 34(5), 1524-1530

P. Duangkaew, S. Inoue, T. Aki, Y. Nakahsimada, Y. Okamura, T. Tajima, Y. Matsumura (2017) In-situ mass spectroscopic analysis of glucose decomposition under hydrothermal condition- Quantitative analysis for reaction kinetics, J. Jpn. Petrol. Inst., 60(2), 101-109

E.K.P. Say, A.T.V. Yabut, N.E.T. Cinco, N.A.L.E. Caguimbal, M.K.P. Devanadera, R.M. Bennett, K.H.V. Arafiles, T. Aki, G.R. Dedeles: Growth and fatty acid production of Halophytophthora S13005YL1-3.1 under different salinity and pH levels. Philipp. Agric. Scientist, 100, S6-11 (2017)

R. Mohamad, T. Aki, Y. Nakashimada, Y. Okamura, T. Tajima, Y. Matsumura: Decomposition kinetics of uronic acids obtained from kelp under hydrothermal condition. J. Energy Inst., 90, 185-190 (2017)

T. Fujimura, T. Aki, T. Isobe, A. Matsuoka, T. Hayashi, K. Ono, S. Kawamoto: Der f 35: An MD-2-like house dust mite allergen that cross-reacts with Der f 2 and Pso o 2. Allergy, 72, 1728-1736 (2017)

河本正次、藤村孝志、秋　庸裕、小埜和久 (2017) 吸入性抗原：最近の進歩／ダニアレルゲン．アレルギー・免疫24: 28-33

大竹久夫他 (2017) リンの事典（分担執筆）、大竹久夫他編、朝倉書店

R. Mohamad, T. Aki, Y. Nakashimada, Y. Okamura, T. Tajima, Y. Matsumura (2016) Decomposition kinetics of mannose, its sugar alcohol, and its uronic acid under hydrothermal condition. J. Chem. Eng. Jpn., 49, 663-667.

R. Mohamad, T. Aki, Y. Nakashimada, Y. Okamura, T. Tajima, Y. Matsumura (2016) Kinetics of sorbitol decomposition under hydrothermal condition. J. Jpn. Petrol. Inst., 59, 149-154

K. G. ElRamlawy, T. Fujimura, K. Baba, J. W. Kim, C. Kawamoto, T. Isobe, T. Abe, K. Hodge-Hanson, D. M. Downs, I. H. Refaat, D. B. Al-Azhary, T. Aki, Y. Asaoku, T. Hayashi, T. Katsutani, S. Tsuboi, K. Ono, S. Kawamoto (2016) Der f 34, a novel major house dust mite allergen belonging to a highly conserved Rid/YjgF/YER057c/UK114 family of imine deaminases. J. Biol. Chem., 291, 21607-21615

A. Kita, K. Kobayashi, T. Miura, Y. Okamura, T. Aki, Y. Matsumura, T. Tajima, N. Nishio, Y. Nakashimada (2016) High-rate fermentation of acetate to methane under saline condition by aceticlastic methanogens immobilized in marine sediment. J. Jpn. Petrol. Inst., 55, 9-15

K. Watanabe, M. Ohno, T. Aki (2016) Detection of acyl-CoA derivatized with butylamide for in vitro fatty acid desaturase assay. J. Oleo Sci. 65, 161-167.

Y. Okamura, S. Nakai, M. Ohkawachi, M. Suemitsu, H. Takahashi, T. Aki, Y. Matsumura, T. Tajima, Y. Nakashimada, M. Matsumoto (2016) Isolation and characterization of bacterium producing lipid from short-chain fatty acids. Bioresour. Technol. 201, 215-221.

K. Watanabe, M. Ohno, M. Taguchi, S. Kawamoto, K. Ono, T. Aki (2016) Identification of amino acid residues that determine the substrate specificity of mammalian membrane-bound front-end fatty acid desaturases. J. Lipid Res. 57, 89-99.

A. Kita, K. Suehira, T. Miura, Y. Okamura, T. Aki, Y. Matsumura, T. Tajima, N. Nishio, Y. Nakashimada (2016) Characterization of a halotolerant acetoclastic methanogen highly enriched from marine sediment and its application to removal of acetate. J. Biosci. Bioeng. 121, 196-202.

T. Miura, A. Kita, Y. Okamura, T. Aki, Y. Matsumura, T. Tajima, J. Kato, Y. Nakashimada (2016) Semi-continuous methane production from undiluted brown algae using a halophilic marine microbial community. Bioresour. Technol. 200, 616-623.

A. Kita, T. Miura, S. Kawata, K. Yamaguchi, Y. Okamura, T. Aki, Y. Matsumura, T. Tajima, J. Kato, Y. Nakashimada (2016) Bacterial community structure and predicted alginate metabolic pathway in an alginate-degrading bacterial consortium. J. Biosci. Bioeng., 121, 286-292.

秋　庸裕、細川雅史 (2016) 海藻カロテノイドと不飽和脂肪酸代謝．化学と生物 54: 308-309

秋　庸裕 (2016) 海藻バイオマスの利用とラビリンチュラによる油脂生産．海洋と生物 38: 36-40

冷牟田修一、秋　庸裕 (2016) バイオマスエネルギーの技術と市場、pp. 22-32（分担執筆）、藻類の分子育種とその応用、シーエムシー出版

中島田豊、喜多晃久、三浦豊和、田島誉久、秋　庸裕、岡村好子、松村幸彦 (2016) 海洋大型藻類からのエネルギー･マテリアル回収. 環境バイオテクノロジー学会誌16: 3-9

A. Kita, T. Miura, S. Kawata, K. Yamaguchi, Y. Okamura, T. Aki, Y. Matsumura, T. Tajima, J. Kato, Y. Nakashimada (2015) Dysgonomonas alginatilytica sp. nov., a novel alginate-degrading bacterium isolated from microbial consortium. Int. J. Sys. Evol. Microbiol. 65, 3570-3575.

T. Miura, T. Yano, A. Kita, Y. Okamura, T. Aki, Y. Matsumura, T. Tajima, J. Kato, Y. Nakashimada (2015) Effect of salinity on methanogenic propionate degradation by acclimated marine sediment-derived culture. Appl. Biochem. Biotechnol. 177: 1541-52.

Matsumoto R., Aki T., Okamura Y., Tajima T., Nakashimada Y., Matsumura Y. (2015) Determination of mannitol decomposition rate under hydrothermal pretreatment condition. J. Jpn. Pet. Inst. 58(4), 252-255.

Miura T., Kita A., Okamura Y., Aki T., Matsumura Y., Tajima T., Kato J., Nakashimada Y. (2015) Improved methane production from brown algae under high salinity by fed-batch acclimation. Bioresour. Technol. 187, 275-281.

Arafiles K.H.V., Iwasaka H., Eramoto Y., Okamura Y., Tajima T., Matsumura Y., Nakashimada Y., Aki T. (2014) Value-added lipid production from brown seaweed biomass by two-stage fermentation using acetic acid bacterium and thraustochytrid. Appl. Microbiol. Biotechnol. 98: 9207-16.

Miura T., Kita A., Okamura Y., Aki T., Matsumura Y., Tajima T., Kato J., Nakashimada Y. (2014) Evaluation of marine sediments as microbial sources for methane production from brown algae under high salinity. Bioresour. Technol. 169C: 362-366.

Watanabe Y., Sato S., Sera S., Sato C., Yoshinaga K., Nagai T., Sato R., Iwasaka H., Aki T. (2014) Enzymatic analysis of positional distribution of fatty acids in solid fat by 1,3-selective transesterification with Candida antarctica lipase B. J. Am. Oil Chem. Soc. 91: 1323-1330.

Matsumoto R., Aki T., Okamura Y., Tajima T., Nakashimada Y., Matsumura Y. (2014) Behavior of organics in kelp during hydrothermal pretreatment: Fundamental characteristics and effect of salt. J. Jpn. Inst. Energy 93: 531-535.

Aki T., Yamamoto M., Takahashi T., Tomita K., Toyoura R., Iwashita K., Kawamoto S., Hosokawa M., Miyashita K., Ono K. (2014) Regulation of polyunsaturated fatty acid biosynthesis by seaweed fucoxanthin and its metabolite in cultured hepatocytes. Lipids 49: 133-141.

Matsumoto R., Aki T., Okamura Y., Tajima T., Nakashimada Y., Matsumura Y. (2013) The behavior of sugar in hydrothermal pretreatment of laminaria. 21st European Biomass Conference and Exhibition (2013. 6. 3-7, Copenhagen, Denmark)

Iwasaka H., Aki T., Adachi H., Watanabe K., Kawamoto S., Ono K. (2013) Utilization of waste syrup for production of polyunsaturated fatty acids and xanthophylls by Aurantiochytrium. J. Oleo Sci. 62, 729-736.

Takaoka Y., Kawamoto S., Katayama A., Yamanaka Y., Nakano T., Chiang K. C., Shimada Y., Ohmori N., Goto T., Aki T., Goto S., Chen C. L., Ono K. (2013) Unexpected T cell regulatory activity of anti-histone H1 autoantibody: its mode of action in regulatory T cell-dependent and -independent manners. Biochem. Biophys. Res. Commun. 431: 246-252.

冷牟田修一、須田彰一郎、秋　庸裕 (2012) 石油業界からみたバイオマスエネルギー、pp. 226-231（分担執筆）、微細藻類によるエネルギー生産と事業展望、竹山春子監修、シーエムシー出版

Ohkouchi K., Kawamoto S., Tatsugawa K., Takaoka Y., Yoshikawa N., Miyauchi S., Aki T., Yamashita M., Murooka Y., Ono K. (2012) Prophylactic effect of Lactobacillus oral vaccine expressing a Japanese cedar pollen allergen. J. Biosci. Bioeng. 113, 536-541.

河本正次、大西伸和、秋　庸裕、小埜和久 (2011) 微粉砕コンニャクグルコマンナンの抗炎症作用．生物機能研究 15: 44-47

河本正次、秋　庸裕、小埜和久 (2011) アレルゲンによる上皮細胞からのTSLP産生誘導．臨床免疫・アレルギー科 56: 473-477

B. Kang, K. Honda, K. Okano, T. Aki, T. Omasa, H. Ohtake (2011) Thermal analysis for differentiating between oleaginous and non-oleaginous microorganisms. Biochem. Eng. J. 57, 23-29.

B. Kang, K. Honda, T. Aki, T. Omasa, H. Ohtake (2011) Simultaneous thermogravimetry and differential thermal analysis for comparing burning characteristics between oleaginous and non-oleaginous microorganisms. Thermochimica Acta 517, 115-20.

W. Jermsuntiea, T. Aki, R. Toyoura, K. Iwashita, S. Kawamoto, K. Ono (2011) Purification and characterization of intracellular lipase from the polyunsaturated fatty acid-producing fungus Mortierella alliacea. New Biotechnol. 28, 158-64

Kawamoto S., Kaneoke M., Ohkouchi K., Amano Y., Takaoka Y., Kume K., Aki T., Watanabe K., Kadowaki M., Hirata D., Ono K. (2011) Sake lees fermented with lactic acid bacteria prevents allergic rhinitis-like symptoms and IgE-mediated basophil degranulation. Biosci. Biotechnol. Biochem. 75, 140-4.

W. Jermsuntiea, T. Aki, S. Kawamoto, K. Ono (2011) Metabolism and synthesis of lipids in the polyunsaturated fatty acid-producing fungus Mortierella alliacea. J. Oleo Sci. 60, 11-7

A.R.N. Ibrahim, S. Kawamoto, K. Mizuno, Y. Shimada, S. Rikimaru, N. Onishi, T. Aki, K. Ono (2010) Molecular cloning and immunochemical characterization of a new Japanese cedar pollen allergen homologous to plant subtilisin-like serine protease. World Allergy Organization J., 3, 262-5

A.R.N. Ibrahim, S. Kawamoto, T. Aki, Y. Shimada, S. Rikimaru, N. Onishi, E. E. Babiker, I. Oiso, K. Hashimoto, T. Hayashi, K. Ono (2010) Molecular Cloning and Immunochemical Characterization of a Novel Major Japanese Cedar Pollen Allergen Belonging to the Aspartic Protease Family. Int Arch Allergy Immunol 152, 207-218

K.W. Fan, T. Aki, F. Chen, Y. Jiang (2010) Enhanced production of squalene in the thraustochytrid Aurantiochytrium mangrovei by medium optimization and treatment with terbinafine. World J. Microbiol. Biotechnol. 26, 1303-9

G. Chen, K.W. Fan, F.P. Lu, Q. Li, T. Aki, F. Chen, Y. Jiang (2010) Optimization of nitrogen source for enhanced production of squalene from thraustochytrid Aurantiochytrium sp. New Biotechnol., 27, 382-9

A.R.N. Ibrahim, S. Kawamoto, M. Nishimura, S. Pak, T. Aki, A. Diaz-Perales, G. Salcedo, J.A. Asturias, T. Hayashi, K. Ono (2010) A new lipid transfer protein homologue identified as an IgE-binding antigen from Japanese cedar pollen. Biosci. Biotechnol. Biochem. 74, 504-9

T. Aki, H. Iwasaka, H. Adachi, M. Nanko, H. Kawasaki, S. Kawamoto, T. Kakizono, K. Ono (2010) Modification of lipid composition by genetic engineering in oleaginous marine microorganism, thraustochytrid. Biocatalysis and Biomolecular Engineering, C.T. Hou and J.F. Shaw, eds., John Wiley & Sons, Inc., pp. 99-104.

Kawamoto S., Aki T., Ono K. (2010) Recombinant allergens for immunotherapy. 1st Annual World Congress of Immunodiseases and Therapy (2010. 5. 15, Beijing, China)

秋　庸裕，河本正次，小埜和久 (2010) アレルギーワクチンの創製．化学と生物 48:453-455

秋　庸裕 (2010) 機能性脂質を生産する海洋微生物ラビリンチュラ類の機能開発と応用．水産油脂技術懇話会記録，財団法人日本水産油脂協会

Q. Li, G.Q. Chen, K.W. Fan, T. Aki, Y. Jiang (2009) Screening and characterization of squalene-producing thraustochytrids from Hong Kong mangroves. J. Agric. Food Chem. 57, 4267-72

K. Kimura, N. Tomita, H. Uemura, T. Aki, K. Ono, Y. Kamisaka (2009) Improvement of stearidonic acid production in oleaginous Saccharomyces cerevisiae. Biosci. Biotechnol. Biochem. 73, 1447-9

K. Ohkohchi, S. Kawamoto, K. Tatsugawa, T. Aki, S. Miyauchi, N. Yoshikawa, M. Yamashita, Y. Murooka, K. Ono (2009) Oral vaccination of lactic acid bacteria expressing a major allergen prevents nasal symptoms and IgE response in a murine model of cedar pollinosis. Proceedings of the World Allergy Congress 2009, pp. 71-4.

J. Kim, S. Kawamoto, Y. Hirano, N. Kitamura, M. Yasuhara, T. Watakabe, T. Aki, K. Ono (2009) Isolation and immunochemical characterization of native Der f 17, a new class of EF-hand calcium-binding allergen from the house dust mite, Dermatophagoides farinae. Proceedings of the World Allergy Congress 2009, pp. 111-5.

鈴木平光他 (2009) 油脂・脂質の基礎と応用，改訂第2版（分担執筆，pp. 40-52, 176-185），日本油化学会編，日本油化学会

Kawamoto S., Nakano T., Aki T., Ohmori N., Goto T., Sato S., Goto S., Chen C. L., Ono K. (2009) Immunosuppressive autoantibody induced by tolerogeneic liver transplantation: its mode of action and clinical application. 1st Annual International Congress of Antibody-2009 (2009. 5. 23, Beijing, China)

Shimada Y, Goto T, Kawamoto S, Kiso T, Katayama A, Yamanaka Y, Aki T, Chiang KC, Nakano T, Goto S, Chen CL, Ohmori N, Ono K, Sato S (2008) Development of a two-step chromatography procedure that allows the purification of a high-purity anti-histone H1 monoclonal immunoglobulin M antibody with immunosuppressant activity. Biomed Chromatogr. 22,13-9

Y. Yamanaka, S. Kawamoto, A. Katayama, T. Kiso, T. Aki, T. Nakano, N. Ohmori, T. Goto, S. Sato, J. Chiang, Y. Shimada, S. Goto, C-. L. Chen, K. Ono (2008) Anti-histone H1 autoantibody directly acts on T cells to exert its immunosuppressive activity. Animal Cell Technology: Basic & Applied Aspects, Kluwer Academic Publishers, Dordrecht, The Netherlands, vol. 15, pp. 153-158.

A. Katayama, S. Kawamoto, Y. Yamanaka, T. Kiso, T. Aki, T. Nakano, N. Ohmori, T. Goto, S. Sato, J. Chiang, Y. Shimada, S. Goto, C-. L. Chen, K. Ono (2008) Anti-histone H1 autoantibody: an inducible immunosuppressive factor in liver transplantation. Animal Cell Technology: Basic & Applied Aspects, Kluwer Academic Publishers, Dordrecht, The Netherlands, vol. 15, pp. 145-151.

R. Poontawe, T. Aki, W. Yongmanitchai (2008) Optimization of DHA and astaxanthin production by Schizochytrium sp. isolated from mangrove forests in Thailand. JSPS-NRCT core university program on development of thermotolerant microbial resources and their applications. pp. 134-135

河本正次，秋　庸裕，小埜和久 (2008) アレルギーワクチンの開発に向けて．バイオインダストリー 25:69-77

Kawamoto S., Aki T., Ono K. (2008) Recombinant allergens for future component-resolved molecular diagnosis and tailor-made immunotherapy. 1st Annual World Congress of Vaccine 2008 (2008. 12. 4, Foshan, Guandong, China)

H. Yazawa, H. Iwahashi, Y. Kamisaka, K. Kimura, T. Aki, K. Ono, H. Uemura (2007) Heterologous production of dihomo-g-linolenic acid in yeast Saccharomyces cerevisiae. Appl. Environ. Microbiol. 73, 6965-6971

N. Onishi, S. Kawamoto, K. Ueda, Y. Yamanaka, A. Katayama, H. Suzuki, T. Aki, K. Hashimoto, M. Hide, K. Ono (2007) Dietary pulverized konjac glucomannan prevents the development of allergic rhinitis-like symptoms and IgE response in mice. Biosci. Biotechnol. Biochem. 71, 2551-2556

T. Yamasaki, T. Aki, Y. Mori, T. Yamamoto, M. Shinozaki, S. Kawamoto, K. Ono (2007) Nutritional enrichment in larval fish feed with thraustochytrid producing polyunsaturated fatty acids and xanthophylls. J. Biosci. Bioeng. 104, 200-206

N. Onishi, S. Kawamoto, H. Suzuki, H. Santo, T. Aki, S. Shigeta, K. Hashimoto, M. Hide, K. Ono (2007) Dietary pulverized konjac glucomannan suppresses scratching behavior and skin inflammatory immune responses in NC/Nga mice. Int. Arch. Allergy Immunol. 144, 95-104

T. Yamasaki, T. Aki, M. Shinozaki, M. Taguchi, S. Kawamoto, K. Ono (2006) Utilization of shochu distillery wastewater for production of polyunsaturated fatty acids and xanthophylls by thraustochytrid. J. Biosci. Bioeng. 102, 323-327

S. Kawamoto, M. Oshita, N. Fukuoka, S. Shigeta, T. Aki, T. Hayashi, K. Nishikawa, K. Ono (2006) Decrease in the allergenicity of Japanese cedar pollen allergen by treatment with positive and negative cluster ions. Int. Arch. Allergy Immunol. 141, 313-321

T. Aki, T. Yamasaki, M. Nanko, M. Shinozaki, S. Kawamoto, and K. Ono (2006) Xanthophylls and Polyunsaturated Fatty Acids Produced by Marine Thraustochytrids. Biocatalysis and Biotechnology for Functional Foods and Industrial Products, C. T. Hou and J. F. Shaw, eds., CRC Press

河本正次，秋　庸裕，小埜和久 (2006) プロテオーム解析によるスギ花粉・ダニアレルゲンの全容解明. アレルギー・免疫 13: 340-344

T. Fujimura, S. Shigeta, T. Suwa, S. Kawamoto, T. Aki, M. Masubuchi, T. Hayashi, M. Hide, K. Ono (2005) Molecular cloning of a class IV chitinase allergen from Japanese cedar (Cryptomeria japonica) pollen and competitive inhibition of its immunoglobulin E-binding capacity by latex C-serum. Clin. Exp. Allergy 35, 234-43

N. Onishi, S. Kawamoto, M. Nishimura, T. Nakano, T. Aki, S. Shigeta, H. Shimizu, K. Hashimoto, K. Ono (2005) A new immunomodulatory function of low-viscous konjac glucomannan with a small particle size: its oral intake suppresses spontaneously occurring dermatitis in NC/Nga mice. Int. Arch. Allergy Immunol. 136, 258–265

T. Aki, S. Kawamoto, S. Shigeta, K. Ono (2005) Fatty acid-modifying enzymes: implications for industrial applications. Handbook of Industrial Biocatalysis, C. T. Hou, ed., CRC press, pp. 15.1–15.11

秋　庸裕 (2005) 高度不飽和脂肪酸の生合成と生産に関する研究. オレオサイエンス 5, 589-599

河本正次，秋　庸裕，重田征子，坪井信治，勝谷　隆，林　鷹治，小埜和久 (2005) ダニアレルゲンー分子種構成，分子多型，ならびに特異的免疫治療ー. アレルギー科 19, 549-556

河本正次，福岡宣彦，大下昌利，秋　庸裕，重田征子，林　鷹治，米田哲也，西川和男，小埜和久 (2005) イオン処理によるダニアレルゲンのアレルゲン性の低減化. アレルギーの臨床 25, 818-822

秋　庸裕，小埜和久 (2005) 海洋微生物による有用脂質の生産と応用．Foods & Food Ingredients J. Jpn. 210, 758-764

伊藤俊洋他 (2005) 油脂・脂質の基礎と応用（分担執筆，pp. 32-43, 162-165），日本油化学会編，日本油化学会

N. Onishi, S. Kawamoto, M. Nishimura, T. Nakano, T. Aki, S. Shigeta, H. Shimizu, K. Hashimoto, K. Ono (2004) The ability of konjac-glucomannan to suppress spontaneously occurring dermatitis in NC/Nga mice depends upon the particle size. Biofactors 21, 163-166

T. Nakano, S. Kawamoto, C.-Y. Lai, T. Sasaki, T. Aki, S. Shigeta, T. Goto, S. Sato, S. Goto, C.-L. Chen, K. Ono (2004) Liver transplantation-induced antihistone H1 autoantibodies suppress mixed lymphocyte reaction. Transplant. 77, 1595-1603

T. Fujimura, S. Shigeta, S. Kawamoto, T. Aki, M. Masubuchi, T. Hayashi, K. Yoshizato, K. Ono (2004) Two-dimensional IgE-binding spectrum of Japanese cedar (Cryptomeria japonica) pollen allergens. Int. Arch. Allergy Immunol. 133, 125-135

T. Nakano, S. Kawamoto, C. Y. Lai, T. Sasaki, T. Aki, S. Shigeta, T. Goto, S. Goto, K. Ono, C.L. Chen (2004) Characterization of immunosuppressive factors expressed in serum by rat tolerogenic liver transplantation. Transplant. Proc. 37, 80-81

山下光雄，金　鍾賢，筒井麻衣子，秋　庸裕，小埜和久，室岡義勝 (2004) 乳酸菌L137株におけるアレルゲン遺伝子の発現―経口減感作療法を目指して―. 生物工学会誌 82, 434-435

秋　庸裕，小埜和久 (2004) 海洋微生物ラビリンチュラと脂質工学．生物工学会誌 82, 288-290

島田弥生，秋　庸裕，大磯　勳，大西伸和，平川雄三，重田征子，橋本邦彦，小埜和久 (2004) 次世代スギ花粉症診断および治療技術の開発．化学工業 55, 48-55

佐藤清隆他 (2004) 機能性脂質のフロンティア（分担執筆，pp. 86-91），シーエムシー出版

阿部正彦他 (2004) 油化学辞典 (編集委員・分担執筆)，日本油化学会編，丸善

J. Huang, T. Aki, T. Yokochi, T. Nakahara, D. Honda, S. Kawamoto, S. Shigeta, K. Ono, O. Suzuki (2003) Grouping newly isolated docosahexaenoic acid-producing thraustochytrids based on their polyunsaturated fatty acid profiles and comparative analysis of 18S rRNA genes. Mar. Biotechnol. 5, 450-457

Y. Michinaka, T. Aki, T. Shimauchi, T. Nakajima, S. Kawamoto, S. Shigeta, O. Suzuki, K. Ono (2003) Differential response to low temperature of two D6 fatty acid desaturases from Mucor circinelloides. Appl. Microbiol. Biotechnol. 62, 362-368

Y. Tanaka, T. Aki, K. Ishihara, S. Kawamoto, S. Shigeta, K. Ono (2003) cDNA cloning and functional expression of a-glucosidase from Mortierella alliacea. Appl. Microbiol. Biotechnol. 62, 202-209

T. Aki, K. Hachida, M. Yoshinaga, Y. Katai, T. Yamasaki, S. Kawamoto, T. Kakizono, T. Maoka, S. Shigeta, O. Suzuki, K. Ono (2003) Thraustochytrid as a potential source of carotenoids. J. Am. Oil Chem. Soc. 80, 789-794

Y. Michinaka, T. Shimauchi, T. Aki, T. Nakajima, S. Kawamoto, S. Shigeta, O. Suzuki, K. Ono (2003) Extracellular secretion of free fatty acids by disruption of fatty acyl-CoA synthetase gene in Saccharomyces cerevisiae. J. Biosci. Bioeng. 95, 435-440

K. Inagaki, T. Aki, T. Shiota, S. Kawamoto, S. Shigeta, O. Suzuki, K. Ono (2003) Evidence of isozymes for D6 fatty acid desaturase in rat hepatocytes. Biosci. Biotechnol. Biochem. 67, 451-454

秋　庸裕，小埜和久 (2003) 微生物によるカロテノイドの生産．オレオサイエンス 3, 175-181

A. Tategaki, S. Kawamoto, T. Okuda, T. Aki, H. Yasueda, O. Suzuki, K. Ono, S. Shigeta (2002) A high-molecular-weight mite antigen (HM1) fraction aggravates airway hyperresponsiveness of allergic mice to house dusts and whole mite cultures. Int. Arch. Allergy Immunol. 129, 204-211

Y. Tanaka, T. Aki, Y. Hidaka, Y. Furuya, S. Kawamoto, S. Shigeta, K. Ono, O. Suzuki (2002) Purification and characterization of a novel fungal a-glucosidase from Mortierella alliacea with high starch-hydrolytic activity. Biosci. Biotechnol. Biochem. 66, 2415-2423

S. Kawamoto, T. Fujimura, M. Nishida, T. Tanaka, T. Aki, M. Masubuchi, T. Hayashi, O. Suzuki, S. Shigeta, K. Ono (2002) Molecular cloning and characterization of a new Japanese cedar pollen allergen homologous to plant isoflavone reductase family. Clin. Exp. Allergy 32, 1064-1070

J. Huang, T. Aki, S. Kawamoto, S. Shigeta, K. Ono, O. Suzuki (2002) Enzymatic preparation of glycerides rich in docosahexaenoic acid from thraustochytrid single cell oils by Candida rugosa lipase. J. Oleo Sci. 51, 447-455

S. Kawamoto, T. Suzuki, T. Aki, T. Katsutani, S. Tsuboi, S. Shigeta, K. Ono (2002) Der f 16: a novel gelsolin-related molecule identified as an allergen from the house dust mite, Dermatophagoides farinae. FEBS Lett. 516, 234-238

A. Tategaki, S. Kawamoto, K. Hashimoto, T. Okuda, T. Aki, O. Suzuki, K. Ono, S. Shigeta (2002) Induction of a proliferative response of T cells by a high-molecular antigen in Dermatophagoides farinae feces. Int. Arch. Allergy Immunol. 127, 276-284

K. Inagaki, T. Aki, Y. Fukuda, S. Kawamoto, S. Shigeta, K. Ono, O. Suzuki (2002) Identification and expression of a rat fatty acid elongase involved in the biosynthesis of C18 fatty acids. Biosci. Biotechnol. Biochem. 66, 613-621

T. Nakano, S. Kawamoto, T. Sasaki, K. Maekawa, T. Aki, S. Shigeta, O. Suzuki, S. Goto, K. Ono (2002) Analysis of immunosuppressive factors expressed in serum of liver transplanted rats. Animal Cell Technology: Basic & Applied Aspects, vol. 12, Kluwer Academic Publishers, Dordrecht, The Netherlands, pp. 257-261

I. Yamaguchi, S. Kawamoto, T. Aki, S. Shigeta, O. Suzuki, K. Ono (2002) Identification of differentially expressed genes in atopic dermatitis-prone NC/Nga mouse. Animal Cell Technology: Basic & Applied Aspects, vol. 12, Kluwer Academic Publishers, Dordrecht, The Netherlands, pp. 379-383

S. Kawamoto, M. Hamada, M. Kita, T. Aki, S. Shigeta, O. Suzuki, K. Ono (2002) Gamma-linolenic acid suppresses IgE production in vitro as well as in vivo. Animal Cell Technology: Basic & Applied Aspects, vol. 12, Kluwer Academic Publishers, Dordrecht, The Netherlands, pp. 461-465

小埜和久，藤村孝志，河本正次，秋　庸裕，重田征子，坪井信治，勝谷　隆，林　鷹治 (2002) スギ花粉，ダニ抗原の分子種構成と分子多型．アレルギー科 14, 275-284

室岡義勝他 (2002) 生物工学実験書 改訂版 (分担執筆，pp. 41-43)，日本生物工学会編，培風館

S. Kawamoto, T. Aki, M. Yamashita, A. Tategaki, T. Fujimura, S. Tsuboi, T. Katsutani, O. Suzuki, S. Shigeta, Y. Murooka, K. Ono (2002) Toward elucidating the full spectrum of mite allergen -- state of the art. J. Biosci. Bioeng. 94, 285-298

J. Huang, T. Aki, K. Hachida, T. Yokochi, S. Kawamoto, S. Shigeta, K. Ono, O. Suzuki (2001) Profile of polyunsaturated fatty acids produced by Thraustochytrium sp. KK17-3. J. Am. Oil Chem. Soc. 78, 605-610

T. Aki, Y. Nagahata, K. Ishihara, Y. Tanaka, T. Morinaga, K. Higashiyama, K. Akimoto, S. Fujikawa, S. Kawamoto, S. Shigeta, K. Ono, O. Suzuki (2001) Production of arachidonic acid by filamentous fungus, Mortierella alliacea strain YN-15. J. Am. Oil Chem. Soc. 78, 599-604

S. Kawamoto, M. Kita, M. Hamada, T. Aki, S. Shigeta, O. Suzuki, K. Ono (2001)Lack of effect of the abnormal fatty acid metabolism in NC/Nga mice on their atopic dermatitis. Biosci. Biotechnol. Biochem. 65, 431-434

T. Nakano, S. Kawamoto, T. Sasaki, K. Maekawa, T. Aki, S. Shigeta, S. Goto, K. Ono (2001) Immunosuppressive autoreactive antibodies induced by liver transplantation. Scand. J. Immunol. 54, Supplement 1, Wed. 109

Y. Michinaka, T. Aki, K. Inagaki, H. Higashimoto, Y. Shimada, T. Nakajima, T. Shimauchi, K. Ono, O. Suzuki (2001) Production of polyunsaturated fatty acids by genetic engineering of yeast. J. Oleo Sci. 50, 359-365

秋　庸裕，鈴木　修 (2001) ラビリンチュラ類における高度不飽和脂肪酸の生合成機構．海洋と生物23, 46-51

秋　庸裕，小埜和久，鈴木　修 (2001) 高度不飽和脂肪酸の生合成：脂肪酸修飾酵素とその利用．科学と工業75, 61-66

菊川清見他 (2001) 油化学便覧 (分担執筆，pp. 487-493)，日本油化学会編，丸善

鈴木修，佐藤清隆，和田俊他 (2001) 機能性脂質の新展開 (分担執筆：脂肪酸不飽和化酵素の遺伝子解析技術の進展，pp. 93-102)，シーエムシー出版

S. Kawamoto, K. Ohno, A. Tategaki, T. Aki, S. Shigeta, T. Jyo, O. Suzuki, K. Ono (2000) T-cell epitope analysis of Mag 3, an impotant allergen from the house dust mite, Dermatophagoides farinae. Immunol. Lett. 72, 53-60

S. Shigeta, S. Kawamoto, T. Aki, O. Suzuki, K. Ono (2000) Purification and characterization of sea squirt a-N-acetylgalactosaminidase. J. Biosci. Bioeng. 89, 84-86

A. Tategaki, S. Kawamoto, T. Aki, T. Jyo, O. Suzuki, S. Shigeta, K. Ono (2000) Newly described house dust mite allergens. Allergy Clin. Immunol. Int. Suppl. 1, 64-67

秋　庸裕，小埜和久，鈴木　修 (2000) 脂肪酸不飽和化系と融合酵素．化学と生物38, 520-527

秋　庸裕，小埜和久，鈴木　修 (2000) 哺乳類のD-6脂肪酸不飽和化酵素：その遺伝子クローニングと生理学的意義．油化学49, 3-10

S. Kawamoto, Y. Mizuguchi, K. Morimoto, T. Aki, S. Shigeta, H. Yasueda, T. Wada, O. Suzuki, T. Jyo, K. Ono (1999) Cloning and expression of Der f 6, a serine protease allergen from the house dust mite, Dermatophagoides farinae. Biochim. Biophys. Acta 1454, 201-207

T. Aki, Y. Shimada, K. Inagaki, H. Higashimoto, S. Kawamoto, S. Shigeta, K. Ono, O. Suzuki (1999) Molecular cloning and functional characterization of rat D-6 fatty acid desaturase. Biochem. Biophys. Res. Commun. 255, 575-579

A. Fujikawa. S. Kawamoto, H. Hokazono, T. Aki, S. Shigeta, O. Suzuki, T. Wada, T. Jyo, K. Ono (1999) Purification and characterization of M-177, a 177 kD allergen, from the house dust mite, Dermatophagoides farinae. Allergol. Int. 48, 43-51

Y. Takeda, K. Ono, S. Kawamoto, T. Aki, M. Masubuchi, T. Hayashi, O. Suzuki, S. Shigeta (1999) A newly identified allergen p29, the C-terminal fragment of Cry j 1, induces potently conjunctival congestion of patients with cedar pollenosis. The 9th Tohwa University International Symposium, pp. 271-274

A. Fujikawa, K. Uchida, A. Yanagidani, S. Kawamoto, T. Aki, S. Shigeta, T. Wada, O. Suzuki, T. Jyo, K. Ono (1998) Altered antigenicity of M-177, a 177 kD allergen from the house dust mite Dermatophagoides farinae, in stored extract. Clin. Exp. Allergy 28, 1549-1558

T. Aki, Y. Matsumoto, T. Morinaga, S. Kawamoto, S. Shigeta, K. Ono, O. Suzuki (1998) Lipid Composition of Newly Isolated Polyunsaturated Fatty Acid Producing Fungus, Achlya sp. ma-2801. J. Ferment. Bioeng. 86, 504-507

S. Adhya, M. Geanacopoulos, D.E.A. Lewis, S. Roy, T. Aki (1998) Transcription regulation by repressosome and by RNA polymerase contact. Cold Spring Harbor Symp. Quant. Biol. 62, 1-10

S. Fujii, K. Ono, A. Takeuchi, T. Aki, S. Shigeta, O. Suzuki, T. Jyo, U. Yamashita (1997) Identification of T cell epitope sequences on an important mite antigen. Clin. Exp. Allergy 27, 1086-1094

H.E. Choy, R.R. Hanger, T. Aki, M. Mahoney, K. Murakami, A. Ishihama, S. Adhya (1997) Repression and activation of promoter-bound RNA polymerase by Gal repressor. J. Mol. Biol. 272, 293-300

T. Aki, S. Adhya (1997) Repressor induced site-specific binding of HU for transcriptional regulation. EMBO J. 16, 3666-3674

Y.L. Lyubchenko, L.S. Shlyakhetenko, T. Aki, S. Adhya (1997) Atomic force microscopic demonstration of DNA looping by GalR and HU. Nucl. Acids Res. 25, 873-876

A. Fujikawa, N. Ishimaru, A. Seto, H. Yamada, T. Aki, S. Shigeta, T. Wada, T. Jyo, Y. Murooka, S. Oka, K. Ono (1996) Cloning and characterization of a new allergen, Mag 3, from the house dust mite, Dermatophagoides farinae: cross-reactivity with high-molecular-weight allergen. Mol. Immunol. 33, 311-319

T. Aki, H.E. Choy, S. Adhya (1996) Histone-like protein HU as a specific transcriptional regulator: co-factor role in repression of gal transcription by Gal repressor. Genes Cells 1, 179-188

秋　庸裕 (1996) DNAの高次構造と転写調節．化学と生物34, 639-641

H.E. Choy, S.W. Park, T. Aki, P. Parrack, N. Fujita, A. Ishihama, S. Adhya (1995) Repression and activation of transcription by Gal and Lac repressors: involvement of alpha subunit of RNA polymerase. EMBO J. 14, 4523-4529

T. Aki, T. Kodama, A. Fujikawa, K. Miura, S. Shigeta, T. Wada, T. Jyo, Y. Murooka, S. Oka, K. Ono (1995) Immunochemical characterization of recombinant and native tropomyosins as a new allergen from the house dust mite, Dermatophagoides farinae. J. Allergy Clin. Immunol. 96, 74-83

T. Aki, K. Ono, Y. Hidaka, Y. Shimonishi, T. Jyo, T. Wada, M. Yamashita, S. Shigeta, Y. Murooka, S. Oka (1994) Structure of IgE epitopes on a new 39kDa allergen molecule from the house dust mite, Dermatophagoides farinae. Int. Arch. Allergy Immunol. 103, 357-364

T. Aki, K. Ono, S.Y. Paik, T. Wada, T. Jyo, S. Shigeta, Y. Murooka, S. Oka (1994) Cloning and characterization of cDNA coding for a new allergen from the house dust mite, Dermatophagoides farinae. Int. Arch. Allergy Immunol. 103, 349-356

T. Aki, A. Fujikawa, T. Wada, T. Jyo, S. Shigeta, Y. Murooka, S. Oka, K. Ono (1994) Cloning and expression of cDNA coding for a new allergen from the house dust mite, Dermatophagoides farinae: Homology with human heat shock cognate proteins in the heat shock protein 70 family. J. Biochem. 115, 435-44