研究業績
4. Akizuki K, Kinumi T, Ono A, Senga Y, Osawa J, Shigeri Y, Ishida A, Kameshita I, Sueyoshi N. Autoactivation of C-terminally truncated Ca2+/calmodulin-dependent
protein kinase (CaMK) Iδ via CaMK kinase-independent autophosphorylation.
1. Kameshita I, Sueyoshi N, Ishida A. In-Gel Protein Phosphatase Assay Using Fluorogenic Substrates.
2. Yamashita M, Sueyoshi N, Yamada H, Katayama S, Senga Y, Takenaka Y,
Ishida A, Kameshita I, Shigeri Y. Characterization of CoPK02, a Ca2+/calmodulin-dependent
protein kinase in mushroom Coprinopsis cinerea.
3. Akizuki K, Toyama T, Yamashita M, Sugiyama Y, Ishida A, Kameshita I, Sueyoshi N. Facile preparation of highly active casein kinase
1 using Escherichia coli constitutively expressing lambda phosphatase.
4. Ishida A, Sueyoshi N, Kameshita I. Functions and dysfunctions of Ca2+/calmodulin-dependent
protein kinase phosphatase (CaMKP/PPM1F) and CaMKP-N/PPM1E.
5. Tanaka M, Ishihara Y, Mizuno S, Ishida A, Tsuji M, Vogel CFA, Yamazaki T, Itoh K. Progression of vasogenic edema induced by activated microglia under permanent middle cerebral artery occlusion. Biochem. Biophys. Res. Commun. 496:582-587 (2018).
6. Baba T, Otake H, Inoue M, Sato T, Ishihara Y, Moon JY, Tsuchiya M, Miyabayashi
K, Ogawa H, Shima Y, Wang L, Yamazaki T, Suyama M, Nomura M, Choi MH, Ohkawa Y, Morohashi K. Ad4BP/SF-1 regulates
cholesterol synthesis to boost the production of steroids. Communications Biology 1:18 (2018).
2017年
1. Shishido Y, Baba T, Sato T, Shima Y, Miyabayashi K, Inoue M, Akiyama
H, Kimura H, Kanai Y, Ishihara Y, Haraguchi S, Miyazaki A, Rozman D, Yamazaki T, Choi MH, Ohkawa Y, Suyama M, Morohashi K. Differential lactate and cholesterol
synthetic activities in XY and XX Sertoli cells. Sci. Rep. 7:41912 (2017).
2. Ishihara Y, Itoh K, Tanaka M, Tsuji M, Kawamoto T, Kawato S, Vogel CFA,
Yamazaki T. Potentiation of 17β-estradiol synthesis in the brain and elongation of seizure latency through dietary supplementation with docosahexaenoic acid. Sci. Rep. 7:6268 (2017).
3. Lee J, Yamazaki T, Dong H, Jefcoate C. A single cell level measurement of StAR expression
and activity in adrenal cells. Mol Cell Endocrinol. 441:22-30 (2017).
4. 山﨑 岳、石原 康宏. ニューロステロイドの合成と機能. 臨床婦人科産科 71巻1号 P. 6-11, 2017年.
5. 山﨑 岳、石原 康宏. ニューロステロイドの神経保護作用. HORMONE FRONTIER IN GYNECOLOGY 24巻 2号 P.57-62, 2017年.
6. 石原 康宏、山﨑 岳. メチル水銀による神経毒性とグリア細胞への作用. Clinical Neuroscience 35巻 12号 P.1398-1401, 2017年.
7. 山﨑 岳. ドコサヘキサエン酸による脳内エストラジオール合成の活性化とてんかん発作の軽減. 第30回水産油脂技術懇話会記録. 一般社団法人日本水産油脂協会.
2016年
1. Takemoto T, Ishihara Y, Tsuji M, Kawamoto T, Yamazaki T. Transcription factor activation in rat primary astrocytes exposed to
methylmercury. Fundam. Toxicol. Sci. 3:63-65 (2016).
2. Ishihara Y, Tsuji M, Kawamoto T, Yamazaki T. Involvement of reactive oxygen species amplified in mitochondria in oxidative
neuronal injury elicited by methylmercury. J. Clin. Biochem. Nutr. 59:182-190 (2016).
3. Ozaki H, Katoh T, Nakagawa R, Ishihara Y, Sueyoshi N, Kameshita I, Taniguchi
T, Hirano T, Yamazaki T, Ishida A. Ca²⁺/calmodulin-dependent protein kinase phosphatase (CaMKP/PPM1F) interacts with neurofilament L and inhibits its filament association. Biochem. Biophys. Res. Commun. 477:820-825 (2016).
4. Senga Y, Akizuki K, Katayama S, Shigeri Y, Kameshita I, Ishida A, Sueyoshi N. High-performance CaMKI: A highly active and stable form of CaMKIδ produced by high-level soluble expression in Escherichia coli. Biochem. Biophys. Res. Commun. 475:277-82 (2016).
5. Ishihara Y, Fujitani N, Sakurai H, Takemoto T, Ikeda-Ishihara N, Mori-Yasumoto
K, Nehira T, Ishida A, Yamazaki T. Effects of sex steroid hormones and their metabolites on neuronal injury
elicited by oxygen-glucose deprivation/reoxygenation in organotypic hippocampal
slice cultures. Steroids. 113:71-77 (2016).
6. Lee J, Tong T, Duan H, Foong YH, Musaitif I, Yamazaki T, Jefcoate C. Regulation of StAR by the N-terminal Domain and Coinduction
of SIK1 and TIS11b/Znf36l1 in Single Cells. Front Endocrinol (Lausanne) 7:107 (2016).
2015年
1. Ishihara Y, Itoh K, Ishida A, Yamazaki T.Selective estrogen-receptor modulators suppress microglial activation
and neuronal cell death via an estrogen receptor-dependent pathway. J Steroid Biochem Mol Biol. 145:85-93 (2015).
2. Ishihara Y, Takemoto T, Ishida A, Yamazaki T. Protective actions of 17β-estradiol and progesterone on oxidative neuronal
injury induced by organometallic compounds (Review Article). Oxid. Med. Cell. Longev. 2015:343706 (2015).
3. Hasegawa Y, Hojo Y, Kojima H, Ikeda M, Hotta K, Sato R, Ooishi Y, Yoshiya
M, Chung BC, Yamazaki T, Kawato S. Estradiol rapidly modulates synaptic plasticity of hippocampal
neurons: Involvement of kinase networks. Brain Res.. 1621:147-161 (2015).
4. Hirano T, Yoshikawa R, Harada H, Harada Y, Ishida A, Yamazaki T. Long noncoding RNA, CCDC26, controls myeloid leukemia cell growth through
regulation of KIT expression. Mol Cancer. 14(1):90 (2015).
5. Senga Y, Ishida A, Shigeri Y, Kameshita I, Sueyoshi N. The Phosphatase-Resistant Isoform
of CaMKI, Ca2+/Calmodulin-Dependent Protein Kinase Iδ (CaMKIδ), Remains
in Its "Primed" Form without Ca2+ Stimulation. Biochemistry. 54:3617-30 (2015).
6. Takemoto T, Ishihara Y, Ishida A, Yamazaki T. Neuroprotection elicited by nerve growth factor and brain-derived neurotrophic
factor released from astrocytes in response to methylmercury. Environ. Toxicol. Pharmacol. 40:199-205 (2015).
7. Ishihara Y, Takemoto T, Itoh K, Ishida A, Yamazaki T. Dual role of SOD2 induced in activated microglia: increased tolerance
to oxidative stress and convergence of inflammatory responses. J. Biol. Chem. 290:22805-22817 (2015).
8. Onouchi T, Kishino-Kaneko Y, Kameshita I, Ishida A, Sueyoshi N. Regulation of Ca(2+)/calmodulin-dependent protein kinase phosphatase (CaMKP/PPM1F) by protocadherin-γC5 (Pcdh-γC5). Arch. Biochem. Biophys. 585:109-120 (2015).
2014年
1. Ishihara Y, Fujitani N, Kawami T, Adachi C, Ishida A, Yamazaki T. Suppressive effects of 17β-estradiol on tributyltin-induced neuronal
injury via
Akt activation and attenuation of oxidative stress in rat hippocampal slices. Life
Sci. 99:24-30 (2014).
2. Baba T, Otake H, Sato T, Miyabayashi K, Shishido T, Wang CY, Shima Y,
Kimura H, Yagi M, Ishihara Y, Hino S, Ogawa H, Nakao M, Yamazaki T, Kang D. Ohkawa Y, Suyama M, Chung BC, Morohashi K. Glycolytic genes are
targets of the nuclear receptor Ad4BP/SF-1. Nat Commun. 5:3634 (2014).
3. Kaneko K, Tabuchi M, Sueyoshi N, Ishida A, Utsumi T, Kameshita I. Cellular localization of CoPK12, a Ca2+/calmodulin-dependent
protein kinase in mushroom Coprinopsis cinerea, is regulated by N-myristoylation.
J Biochem. 156:51-61 (2014).
4. Munetsuna E, Hattori M, Yamazaki T. Stimulation of estradiol biosynthesis by tributyltin in rat hippocampal
slices. Endocr Res. 39:168-72 (2014).
5. Yamazaki T, Ishihara Y. Neurosteroids: regional steroidogenesis. Fifty Years of Cytochrome P450 Research. 153-173 Springer Japan (2014).
2013年
1. Oki K, Kopf PG, Campbell WB, Luis Lam M, Yamazaki T, Gomez-Sanchez CE, Gomez-Sanchez EP. Angiotensin II and III Metabolism and Effects on Steroid Production in the HAC15 Human Adrenocortical Cell Line. Endocrinology 154:214-21 (2013).
2. Ishihara Y, Kawami T, Ishida A, Yamazaki T. Allopregnanolone-mediated protective effects of progesterone on tributyltin-induced
neuronal injury in rat hippocampal slices. J Steroid Biochem Mol Biol. 135:1-6 (2013).
3. Yamazaki T, Yamamoto M, Ishihara Y, Onizaki M, Komatsu S, Munetsuna E, Ishida A, Kawato S, Mukuda T. De novo synthesized estradiol protects against methylmercury-induced neurotoxicity
in cultured rat hippocampal slices. Pros One. 8:e55559 (2013).
4. Ishihara Y, Itoh K, Mitsuda Y, Shimada T, Kubota T, Kato C, Song SY,
Kobayashi Y, Mori-Yasumoto K, Sekita S, Kirino Y, Yamazaki T, Shimamoto N. Involvement of brain oxidation in the cognitive impairment
in a triple transgenic mouse model of Alzheimer's disease: Non-invasive
measurement of the brain redox state by magnetic resonance imaging. Free Radic Res. 47:731-739 (2013).
5. Kaneko K, Sueyoshi N, Kameshita I, Ishida A, Ink-native electrophoresis: An alternative to blue-native electrophoresis
more suitable for in-gel detection of enzymatic activity. Anal. Biochem. 440:142-144 (2013).
6. Hasegawa Y, Ogiue-Ikeda M, Tanabe N, Kimoto T, Hojo Y, Yamazaki T, Kawato S. Bisphenol A significantly modulates long-term depression in the hippocampus as observed by multi-electrode system. Neuro Endocrinol Lett. 34:129-34 (2013).
7. Ishida A, Tsumura K, Oue M, Takenaka Y, Shigeri Y, Goshima N, Ishihara Y, Hirano
T, Baba H, Sueyoshi N, Kameshita I, Yamazaki T. An active C-terminally truncated form of Ca2+/calmodulin-dependent protein kinase phosphatase-N (CaMKP-N/PPM1E). BioMed Res. Int. 2013:134813 (2013).
8. Matsumura S, Ohta T, Takahashi T, Yamazaki T, Takahashi K, Kurachi H. Non-sex cord-stromal ovarian tumors frequently produce and secrete estrogen in postmenopausal women: impact on bone metabolism and abnormal endometrial histology. J Clin Endocrinol Metab. 98:2775-82 (2013)..
2012年
1. Sueyoshi N, Nimura T, Onouchi T, Baba H, Takenaka S, Ishida A, Kameshita I. Functional processing of nuclear Ca(2+)/calmodulin-dependent
protein kinase phosphatase (CaMKP-N): evidence for a critical role of proteolytic
processing in the regulation of its catalytic activity, subcellular localization
and substrate targeting in vivo. Arch Biochem Biophys. 517:43-52 (2012).
2. Takeda K, Ishida A, Takahashi K, Ueda T. Synaptic vesicles are capable of synthesizing the
VGLUT substrate glutamate from α-ketoglutarate for vesicular loading. J Neurochem. 121:184-96 (2012).
3. Ishihara Y, Kawami T, Ishida A, Yamazaki T. Tributyltin induces oxidative stress and neuronal injury by inhibiting glutathione S-transferase in rat organotypic hippocampal slice cultures. Neurochem Int. 60:782-90 (2012).
4. Onouchi T, Sueyoshi N, Ishida A, Kameshita I. Phosphorylation and activation of nuclear Ca(2+)/calmodulin-dependent protein kinase phosphatase (CaMKP-N/PPM1E) by Ca(2+)/calmodulin-dependent protein kinase I (CaMKI). Biochem Biophys Res Commun. 422:703-9 (2012).
5. Baba H, Sueyoshi N, Shigeri Y, Ishida A, Kameshita I. Regulation of Ca2+/calmodulin-dependent protein kinase phosphatase (CaMKP) by oxidation/reduction at Cys-359 Arch Biochem Biophys. 526:9-15 (2012).
6. Nehira T, Ishihara K, Matsuo K, Izumi S, Yamazaki T, Ishida A. A sensitive method based on fluorescence-detected circular dichroism
for protein local structure analysis. Anal Biochem. 430:179-184 (2012)
7. 石田 敦彦 「ミカエリス・メンテンの式」 『脳科学辞典』 脳科学辞典編集委員会編、(2012).
8. 茂里 康、石田 敦彦、高尾 俊彦、末吉 紀行、亀下 勇：Ca2+/calmodulin-dependent protein kinase phosphatase
(CaMKP)の特異的阻害剤, 日本国公開特許公報 特許公開2008-189622（公開日：2008/8/21）特許第5105348号 (登録日：2012/10/12).
9. 杉山康憲、末吉 紀行、亀下 勇、茂里 康、達吉郎、湯元 昇、石田 敦彦、谷口 隆信：抗チロシンキナーゼ抗体およびその利用, 特許第4956816号（2012/3/30登録）