プロフィール (go to English Version)
荒川 賢治（あらかわ けんじ）
〒739-8530
広島県東広島市鏡山 1-3-1
広島大学 大学院統合生命科学研究科
生物工学プログラム 細胞機能化学研究室
TEL & FAX: 082-424-7767
E-mail : karakawa (at) hiroshima-u.ac.jp
学歴及び職歴：
1995年3月 東京工業大学理学部化学科卒業（柿沼勝己教授）、学士（理学）
1995年4月 東京工業大学大学院理工学研究科化学専攻修士課程入学
1997年3月 東京工業大学大学院理工学研究科化学専攻修士課程卒業（柿沼勝己教授）、修士（理学）
1997年4月 東京工業大学大学院理工学研究科化学専攻博士課程入学
1999年1月-1999年9月 日本学術振興会特別研究員（DC）
1999年9月 東京工業大学大学院理工学研究科化学専攻博士課程卒業（柿沼勝己教授・江口正助教授）、博士（理学）
1999年10月 日本学術振興会特別研究員（PD）
1999年11月 米国ワシントン大学博士研究員（Heinz G. Floss 教授）
2002年4月 広島大学大学院先端物質科学研究科分子生命機能科学専攻 助手
2007年4月 広島大学大学院先端物質科学研究科分子生命機能科学専攻 助教
2010年9月 広島大学大学院先端物質科学研究科分子生命機能科学専攻 准教授
2019年4月 広島大学大学院統合生命科学研究科生物工学プログラム 准教授
2024年4月 広島大学大学院統合生命科学研究科生物工学プログラム 教授（現職）
報文目録：
論文（査読付き）
Rukman Muslimin†, Alimuddin Ali†, Sho Ogaki, Nurjannah, Ummu Kalsum Alam, Sisun Choi, Eung-Soo Kim, and Kenji Arakawa*.
“Detection of seco-macrotetrolides caused by regiospecific hydrolysis in Indonesian Streptomyces strains isolated at the karst area in Sulawesi Island7434AN4”
Tetrahedron 160, 134045 (2024).
Yu Tanaka†, Haruka Nagano†, Mei Okano, Takuya Kishimoto, Ayaka Tatsukawa, Hirofumi Kunitake, Atsushi Fukumoto, Yojiro Anzai, and Kenji Arakawa.
“Isolation of hydrazide-alkenes with different amino-acid origins from an azoxy-alkene-producing mutant of Streptomyces rochei 7434AN4”
Journal of Natural Products, 86, 2185-2192 (2023).
Yuya Misaki, Tomomi Hirashima, Karin Fujii, Asahi Hirata, Yutaro Hoshino, Miho Sumiyoshi, Sachiko Masaki, Toshihiro Suzuki, Kuninobu Inada, Hiroki Koyama, Hisato Kuniyoshi, and Kenji Arakawa.
“4-Methoxy-2,2’-bipyrrole-5-carbaldehyde, a biosynthetic intermediate of bipyrrole-containing natural products from the Streptomyces culture, arrests the strobilation of moon jellyfish Aurelia coerulea”
Frontiers in Marine Science,10, 1198136 (2023).
Mingge Zhang, Bao Shuang, and Kenji Arakawa.
“New lankamycin derivative with a branched-chain sugar from a blocked mutant of chalcose
biosynthesis in Streptomyces rochei 7434AN4”
Bioorg. Med. Chem. Lett., 80, 129125 (2023).
Islam A.T.M. Rafuqul, Keita Shinzato, Hiroki Miyaoka, Kenji Komaguchi, Kanae Koike, Kenji Arakawa, Kenji Kitamura, Nobukazu Tanaka.
”Isolation and characterization of blackish-brown BY2-melanin accumulated in cultured tobacco BY-2 cells”
Biosci. Biotechnol. Biochem., 87, 395-410 (2023).
Aoi Takeuchi, Asahi Hirata, Aiko Teshima, Miu Ueki, Takumi Satoh, Kenichi, Matsuda, Toshiyuki Wakimoto, Kenji Arakawa, Morio Ishikawa, and Toshihiro Suzuki.
“Characterization of the surugamide biosynthetic gene cluster of TUA-NUK25, a Streptomyces diastaticus strain isolated from Kusaya and its effects on salt-dependent growth”
Biosci. Biotechnol. Biochem., 87, 320-329 (2023).
Ahmed Taha Ayoub, Natsumi Nishiura, Aiko Teshima, Mohamed Ali Elrefaiy, Rukman Muslimin, Kiep Minh Do, Takeshi Kodama, Cody Wayne Lewis, Gordon Chan, Hiroyuki Morita, and Kenji Arakawa.
“Bio-inspored computational design of lankacidin derivatives for the improvement of antitumor activity”
Future Medicinal Chemistry, 14, 1349-1360 (2022).
Ayaka Tatsukawa, Yu Tanaka, Haruka Nagano, Atsushi Fukumoto, Yojiro Anzai, and Kenji Arakawa.
“Isolation, biosynthetic investigation, and biological evaluation of maniwamycin G, an azoxyalkene compound from Streptomyces sp. TOHO-M025”
Journal of Natural Products, 85, 1867-1871 (2022).
Yuya Misaki, Yuzuru Takahashi, Keisuke Hara, Satoshi Tatsuno, and Kenji Arakawa.
“Three 4-monosubstituted butyrolactones from a regulatory gene mutant of Streptomyces rochei 7434AN4”
J. Biosci. Bioeng., 133, 329-334 (2022).
Kenji Arakawa and Toshihiro Suzuki.
“Regulation of secondary metabolites through signaling molecules in Streptomyces”
in Natural Products from Actinomycetes – Diversity, Ecology and Drug Discovery -, Eds Ravishankar V. Rai and Jamuna A. Bai, pp. 167-184, Springer Nature (2022).
Kazuya Yamanaka, Hibiki Fukumoto, Naoki Yoshimura, Kenji Arakawa, Yasuo Kato, Yoshimitsu Hamano, and Tadao Oikawa.
“Discovery of a poly-amino acid antibiotic solely comprising of L-beta-lysine by potential producer prioritization-guided genome mining”
ACS Chemical Biology, 17, 171-180 (2022).
Rukman Muslimin, Natsumi Nishiura, Aiko Teshima, Kiep Minh Do, Takeshi Kodama, Hiroyuki Morita, Cody Wayne Lewis, Gordon Chan, Ahmed Taha Ayoub, and Kenji Arakawa.
“Chemoenzymatic synthesis, computational investigation, and antitumor activity of monocyclic lankacidin derivatives”
Bioorganic & Medicinal Chemistry, 53, 116551 (2022).
Yuya Misaki, Yosi Nindita, Kota Fujita, Amirudin Akhmad Fauzi, Kenji Arakawa.
“Overexpression of SRO_3163, a homolog of Streptomyces antibiotic regulatory protein, induces the production of novel cyclohexene-containing enamide in Streptomyces rochei”
Biosci. Biotechnol. Biochem., 86, 177-184 (2022).
Aiko Tanaka, Maarten H. Ryder, Takamasa Suzuki, Kazuma Uesaka, Nobuo Yamaguchi, Tomoko Amimoto, Motoyasu Otani, Osamu Nakayachi, Kenji Arakawa, Nobukazu Tanaka, and Daigo Takemoto.
“Production of agrocinopine A by Ipomoea batatas agrocinopine synthase in transgenic tobacco and its effect on the rhizosphere microbial community”
Molecular Plant-Microbe Interactions, 35, 73-84 (2022).
Aiko Teshima, Hisashi Kondo, Yu Tanaka, Yosi Nindita, Yuya Misaki, Yuji Konaka, Yasuhuri Itakura, Tsugumi Tonokawa, Haruyasu Kinashi, and Kenji Arakawa.
“Substrate specificity of two cytochrome P450 monooxygenases involved in lankamycin biosynthesis”
Biosci. Biotechnol.
Biochem., 85, 115-125 (2021).
Aiko Teshima, Nozomi Hadae, Naoto Tsuda, Kenji Arakawa.
“Functional analysis of P450 monooxygenase
SrrO in the biosynthesis of butenolide-type signaling molecules in Streptomyces rochei”
Biomolecules, 10, 1237 (2020).
Yuya Misaki, Shouji Yamamoto, Toshihiro Suzuki, Miyuki Iwakuni, Hiroaki Sasaki, Yuzuru Takahashi,
Kuninobu Inada, Haruyasu Kinashi, and Kenji Arakawa.
“SrrB, a pseudo-receptor protein, acts as a negative regulator for lankacidin
and lankamycin production in Streptomyces rochei”
Tetsuya Yamamoto, Ryo Furuta, Kenji Arakawa, Aiko Teshima.
“Relationship
between dispersion-forming capability of poly(4-vinylaniline) colloids and
antimicrobial activity”
Colloids and Surfaces A: Physicochemical and
Engineering Aspects, 596, 124736 (2020).
Tetsuya Yamamoto, Kenji Arakawa, Ryo Furuta, Aiko Teshima.
“Influence of the morphology and size of
polystyrene synthesized through soap-free emulsion polymerization on
antimicrobial activity”
Materials Today Communications, 20, 100572 (2019).
Yosi Nindita, Zhisheng Cao, Amirudin Akhmad Fauzi, Aiko Teshima, Yuya Misaki,
Rukman Muslimin, Yingjie Yang, Yuh Shiwa, Hirofumi Yoshikawa, Michihira
Tagami, Alexander Lezhava, Jun Ishikawa, Makoto Kuroda, Tsuyoshi Sekizuka,
Kuninobu Inada, Haruyasu Kinashi, Kenji Arakawa.
“The genome sequence of Streptomyces rochei 7434AN4, which carries a
linear chromosome and three characteristic linear plasmids”
Scientific Reports, 9, 10973 (2019).
Ahmed Taha Ayoub, Mohamed Ali Elrefaiy, Kenji Arakawa.
“Computational prediction of the mode of binding
of antitumor lankacidin C to tubulin”
ACS
Omega, 4, 4461-4471 (2019).
Naoya Toyoda, Tetsuya Yamamoto, Kenji Arakawa, Aiko Teshima.
“Preparation of PVA/polymer colloid nanocomposite hydrogel using PS-PNVA
particles”
Chem. Lett., 48, 378-381 (2019).
Tetsuya
Yamamoto, Kenji Arakawa, Yuya Takahashi, Miho Sumiyoshi.
“Antimicrobial
activities of low molecular weight polymers synthesized through soap-free
emulsion polymerization”
Eur. Polym. J., 109, 532-536 (2018).
Tetsuya
Yamamoto, Kenji Arakawa, Ryo Furuta, Aiko Teshima.
“Antimicrobial
activities of polymers synthesized through soap-free emulsion polymerization
using a cationic initiator and styrene derivative monomers”
Chem. Lett., 47, 1402-1404 (2018). DOI: 10.1246/cl.180762
Yusuke Yamauchi, Yosi Nindita, Keisuke Hara, Asako Umeshiro, Yu Yabuuchi,
Toshihiro Suzuki, Haruyasu Kinashi, Kenji Arakawa.
“Quinoprotein dehydrogenase functions at the final oxidation step of lankacidin
biosynthesis in Streptomyces rochei 7434AN4”
J. Biosci. Bioeng., 126, 145-152 (2018).
Kenji Arakawa.
“Manipulation of
metabolic pathway controlled by signaling molecules, inducers of antibiotic
production, for genome mining in Streptomyces spp.”
Antonie van Leeuwenhoek., 111, 743-751 (2018).
Natsumi Tsujita, Hiroyuki Kuwahara, Hiroki Koyama, Noriyuki Yanaka, Kenji Arakawa, Hisato
Kuniyoshi.
“Molecular characterization of aspartylglucosaminidase, a lysosomal
hydrolase upregulated during strobilation in the moon jellyfish, Aurelia aurita”
Biosci. Biotechnol.
Biochem., 81, 938-950 (2017).
Rikiya Kamei, Takashi Fujimura, Miki Matsuda, Kotaro Kakihara, Noriko Hirakawa,
Kenji Baba, Kazuhisa Ono, Kenji Arakawa, Seiji Kawamoto.
“A flavanone derivative from the Asian medicinal herb (Perilla
frutescens) potently suppresses
IgE-mediated immediate hypersensitivity reactions”
Biochem.
Biophys. Res. Commun., 483, 674-679 (2017).
Ahmed Taha Ayoub, Rabab M. Abou El-Magd, Jack Xiao, Cody Wayne Lewis, Tatiana Martins Tilli,
Kenji Arakawa, Yosi Nindita, Gordon Chan, Luxin Sun, Mark Glover, Mariusz
Klobukowski, Jack Tuszynski.
“Antitumor activity of lankacidin antibiotics is due to microtubule
stabilization via a paclitaxel-like mechanism”
J. Med. Chem., 59, 9532-9540 (2016).
Hirofumi Kunitake, Takahiro Hiramatsu, Haruyasu Kinashi, Kenji Arakawa.
“Isolation and biosynthesis of an azoxyalkene compound produced by a multiple
gene disruptant of Streptomyces rochei”
ChemBioChem,16, 2237-2243 (2015).
Yosi Nindita, Zhisheng Cao, Yingjie Yang, Kenji Arakawa, Yuh Shiwa, Hirofumi
Yoshikawa, Michihira Tagami, Alexander Lezhava, Haruyasu Kinashi.
“The tap-tpg gene pair on the linear plasmid functions to maintain a linear topology
of the chromosome in Streptomyces rochei”
Mol. Microbiol., 95, 846-858 (2015).
Zhisheng Cao, Ryuhei Yoshida, Haruyasu Kinashi, Kenji Arakawa.
“Blockage of the early step of lankacidin biosynthesis caused a large
production of pentamycin, citreodiol, and epi-citreodiol in Streptomyces rochei”
J. Antibiot., 68, 328-333 (2015).
Kenji Arakawa.
“Genetic and
biochemical analysis of the antibiotic biosynthetic gene clusters on the Streptomyces linear plasmid”
Biosci. Biotechnol. Biochem., 78, 183-189 (2014).
Yosi Nindita, Tomoya Nishikawa, Kenji Arakawa, Guojun Wang, Kozo Ochi,
Zhongjun Qin, Haruyasu Kinashi.
“Chromosome circularization of the model Streptomyces species, Streptomyces coelicolor A3(2)”
FEMS Microbiol. Lett., 347, 149-155 (2013).
Hisato Kuniyoshi, Izumi Okumura, Rie Kuroda, Kenji Arakawa, Jun Shoji, Tamio Saito, Hiroyuki
Osada.
“Indomethacin induces transition from asexual stage to sexual state in the
moon jellyfish, Aurelia aurita”
Biosci. Biotechnol. Biochem., 76, 1397-1400 (2012).
Kenji Arakawa, Naoto Tsuda, Akihiro Taniguchi, Haruyasu Kinashi.
“The butenolide signaling molecules SRB1 and SRB2 induce lankacidin and
lankamycin production in Streptomyces rochei”
ChemBioChem,13, 1447-1457 (2012).
Zhisheng Cao, Gholam Khodakaramian, Kenji Arakawa, Haruyasu Kinashi.
“Isolation of borrelidin as a phytotoxic compound from a potato pathogenic Streptomyces strain”
Biosci. Biotechnol. Biochem., 76, 353-357 (2012).
Kenji Arakawa.
“Diversity
between PKS and FAS”
Nature
Chem. Biol., 8, 604-605 (2012).
Yingjie Yang, Toru Kurokawa, Yoshifumi Takahama, Yosi Nindita, Susumu Mochizuki,
Kenji Arakawa, Satoru Endo, Haruyasu Kinashi.
“pSLA2-M of Streptomycesrochei is a composite linear
plasmid characterized by self-defense genes and homology with pSLA2-L”
Biosci.
Biotechnol. Biochem., 75, 1147-1153 (2011).
Kenji Arakawa, Zhisheng Cao,
Natsumi Suzuki, Haruyasu Kinashi.
“Isolation, structural elucidation, and biosynthesis of 15-norlankamycin
derivatives produced by a type-II thioesterase disruptant of Streptomycesrochei”
Tetrahedron, 67, 5199-5205 (2011).
Matthew J. Belousoff, Tal Shapira, Anat Bashan, Ella Zimmerman, Haim Rozenberg,
Kenji Arakawa, Haruyasu Kinashi, Ada Yonath.
“Crystal structure of the synergistic antibiotic pair, lankamycin and
lankacidin, in complex with the large ribosomal subunit”,
Proc. Natl. Acad. Sci. USA, 108, 2717-2722 (2011).
Heinz G. Floss*, Tin-Wein Yu, Kenji Arakawa
“The biosynthesis
of 3-amino-5-hydroxybenzoic acid (AHBA), the precursor of mC7N-units
in ansamycin and mitomycin antibiotics - A review”
J.
Antibiot., 64, 35-44 (2011).
Toshihiro Suzuki, Susumu Mochizuki, Shouji Yamamoto, Kenji Arakawa, Haruyasu
Kinashi.
“Regulation of lankamycin biosynthesis in Streptomyces rochei by
two SARP genes, srrY and srrZ”
Biosci. Biotechnol. Biochem., 74, 819-827 (2010).
Kenji Arakawa.
“Characterization
of the biosynthetic gene clusters located on the Streptomyces linear plasmid”
Actinomycetol., 24, 24-30 (2010).
Tamar Auerbach, Inbal Mermershtain, Chen Davidovich, Anat Bashan, Matthew
Belousoff, Itai Wekselman, Ella Zimmerman, Liqun Xiong, Dorota Klepacki,
Kenji Arakawa, Haruyasu Kinashi, Alexander Mankin, Ada Yonath.
“The structure of ribosome-lankacidin complex reveals ribosomal sites for
synergistic antibiotics”
Proc. Natl. Acad. Sci. USA, 107, 1983-1988 (2010).
Satoshi Tatsuno, Kenji Arakawa, Haruyasu Kinashi.
“Extensive mutational analysis of modular-iterative mixed polyketide biosynthesis
of lankacidin in Streptomycesrochei”
Biosci. Biotechnol. Biochem., 73, 2712-2719 (2009).
Kenji Arakawa, Toshihiro Suzuki, Haruyasu Kinashi.
“Gene disruption analysis of two glycosylation steps in lankamycin biosynthesis
in Streptomycesrochei”
Actinomycetol., 22, 35-41 (2008).
Shouji Yamamoto, Yuxi He, Kenji Arakawa, Haruyasu Kinashi.
“Gamma-Butyrolactone-dependent expression of the SARP gene srrY plays a
central role in the regulatory cascade leading to lankacidin and lankamycin
production in Streptomyces rochei”
J. Bacteriol., 190, 1308-1316 (2008).
Satoshi Tatsuno, Kenji Arakawa, Haruyasu Kinashi.
“Analysis of modular-iterative mixed biosynthesis of lankacidin by heterologous
expression and gene fusion”
J. Antibiot., 60, 700-708 (2007).
Kenji Arakawa, Susumu
Mochizuki, Kohei Yamada, Takenori Noma, Haruyasu Kinashi.
”Gamma-Butyrolactone
autoregulator-receptor system involved in lankacidin and lankamycin production
and morphological differentiation in Streptomyces rochei”
Microbiology, 153, 1817-1827 (2007).
Kenji Arakawa, Kazuya Kodama, Satoshi Tatsuno, Sayoko Ide, Haruyasu Kinashi.
"Analysis of the loading and hydroxylation
steps in lankamycin biosynthesis in Streptomyces rochei”
Antimicrob. Agents Chemother., 50, 1946-1952 (2006).
Kenji Arakawa, Fuminori Sugino, Kazuya Kodama, Tatsuya Ishii, Haruyasu Kinashi.
"Cyclization mechanism for the synthesis of
macrocyclic antibiotic lankacidin in Streptomyces rochei"
Chem. Biol., 12, 249-256 (2005).
Kenji Arakawa, Simeon G. Bowers, Benjamin Michels, Vu Trin, and Taifo Mahmud
"Biosynthetic studies on the a-glucosidase inhibitor acarbose: the chemical synthesis of isotopically labeled 2-epi-5-epi-valiolone analogs"
Carbohydr. Res., 338 [20], 2075-2082 (2003).
Kenji Arakawa, Rolf Mller, Taifo Mahmud, Tin-Wein Yu, and Heinz G. Floss
"Characterization of the Early Stage Aminoshikimate Pathway in the Formation of 3-Amino-5-hydroxybenzoic Acid: The RifN Protein Specifically Converts Kanosamine into Kanosamine 6-phosphate"
J. Am. Chem. Soc., 124 [36], 10644-10645 (2002).
Hiroshi Naganawa, Hideki Hashizume, Yumiko Kubota, Ryuichi Sawa, Yoshikazu Takahashi, Kenji Arakawa, Simeon G. Bowers, and Taifo Mahmud
"Biosynthesis of the Cyclitol Moiety of Pyralomicin 1a in Nonomuraea spiralis MI178-34F18"
J. Antibiot., 55 [6], 578-584 (2002).
Kenji Arakawa, Tadashi Eguchi, and Katsumi Kakinuma
"Highly Thermostable Liposome from 72-Membered Macrocyclic Tetraether Lipid: Importance of 72-Membered Lipid for Archaea to Thrive under Hyperthermal Environments"
Chem. Lett., [5], 440-441 (2001).
Kenji Arakawa, Tadashi Eguchi, and Katsumi Kakinuma
"36-Membered Macrocyclic Diether Lipid is Advantageous for Archaea to Thrive under the Extreme Thermal Environments"
Bull. Chem. Soc. Jpn., 74 [2], 347-356 (2001).
Tadashi Eguchi, Kenji Arakawa, Katsumi Kakinuma, Sangita Ghosh, Yoichi Nakatani, and Guy Ourisson
"Giant Vesicles from 72-Membered Macrocyclic Archaeal Phosphokipid Analogues: Initiation of Vesicle Formation by Molecular Recognition between Membrane Components"
Chem. Eur. J., 6 [18], 3351-3358 (2000).
Olivier Dannenmuller, Kenji Arakawa, Tadashi Eguchi, Katsumi Kakinuma, Sylvie Blanc, Anne-Marie Albrecht, Marc Schmutz, Yoichi Nakatani, and Guy Ourisson
"Membrane Properties of Archaeal Macrocyclic Diether Phospholipids"
Chem. Eur. J., 6 [4], 645-654 (2000).
Kenji Arakawa, Hiroki Kano, Tadashi Eguchi, Yayoi Nishiyama, and Katsumi Kakinuma
"Significance of the 72-Membered Macrocyclic Structure Found in Archaeal Membrane Lipids: Model Studies of the Macrocyclic Tetraether Diphospholipids by Calorimetric, 31P NMR, and Electron Microscopic Analyses"
Bull. Chem. Soc. Jpn., 72 [7], 1575-1581 (1999).
Kenji Arakawa, Tadashi Eguchi, and Katsumi Kakinuma
"Specific Deuterium Labeling of Archaeal 36-Membered Macrocyclic Diether Lipid"
Bull. Chem. Soc. Jpn., 71 [10], 2419-2426 (1998).
Kenji Arakawa, Tadashi Eguchi, and Katsumi Kakinuma
"Tightly Packed Membranes Composed of 36-Membered Macrocyclic Diether Phospholipid Found in Archaea Growing under Deep-sea Hydrothermal Vents"
Chem. Lett., [9], 901-902 (1998).
Kenji Arakawa, Tadashi Eguchi, and Katsumi Kakinuma
"An Olefin Metathesis Approach to 36- and 72-Membered Archaeal Macrocyclic Membrane Lipids"
J. Org. Chem., 63 [14], 4741-4745 (1998).
Kazuhiro Taguchi, Kenji Arakawa, Tadashi Eguchi, and Katsumi Kakinuma, Yoichi Nakatani, Guy Ourisson
"Synthesis of Macrocyclic Phosphates as Models of Archaeal Membrane Lipids. Monolayer and Bilayer Studies"
New. J. Chem., 22 [1], 63-69 (1998).
Tadashi Eguchi, Hiroki Kano, Kenji Arakawa, and Katsumi Kakinuma
"Synthetic Studies of Archaeal Macrocyclic Tetraether Lipids: Practical Synthesis of 72-Membered Tetraether Model Compounds"
Bull. Chem. Soc. Jpn., 70 [10], 2545-2554 (1997).
Tadashi Eguchi, Kenji Arakawa, Takumi Terachi, and Katsumi Kakinuma
"Total Synthesis of Archaeal 36-Membered Macrocyclic Diether Lipid"
J. Org. Chem., 62 [7], 1924-1933 (1997).
総説・解説・Proceedings
見崎 裕也, 荒川 賢治.
「転写制御因子の改変による放線菌二次代謝活性化」
アグリバイオ, 5 [1], 62-65 (2021).
見崎 裕也, 荒川 賢治.
「ゲノム情報を利活用した休眠二次代謝の活性化」
生物工学会誌, 98 [5], 257 (2020).
稲田 晋宣, 荒川 賢治.
「生理活性天然物を創出する放線菌遺伝資源の利活用」
アグリバイオ, 4 [3], 216-219 (2020).
鈴木 敏弘, 原 圭佑, 荒川 賢治.
「土壌放線菌で初めて見いだされたキノン補酵素要求性デヒドロゲナーゼの機能」
アグリバイオ, 3 [9], 984-987 (2019)
手島 愛子, 見崎 裕也, 荒川 賢治.
「制御因子およびシグナル分子に注目した放線菌二次代謝生合成の合理的活性化戦略」
アグリバイオ, 3 [4], 391-394 (2019).
手島 愛子, 荒川 賢治.
「微生物における共存と二次代謝生産」
生物工学会誌, 97 [3], 138 (2019).
原 圭佑, 鈴木 敏弘, 荒川 賢治.
「抗生物質生合成を司るピロロキノリンキノン要求性デヒドロゲナーゼ」
バイオサイエンスとインダストリー，77 [2], 119-121 (2019).
手島 愛子, 見崎 裕也, 荒川 賢治.
「悉皆的ゲノムマイニングを指向した放線菌二次代謝生合成・誘導制御の分子基盤の統合深化」
アグリバイオ, 2 [14], 1392-1395 (2018).
國武 博文, 岸本 拓也, 達川 綾香, 木梨 陽康, 福本 敦, 安齊 洋次郎, 荒川 賢治.
「二次代謝生合成・制御系の合目的改変により取得したアゾキシアルケン化合物 KA57-Aの生合成及び生物活性」
第５９回天然有機化合物討論会講演要旨集, pp. 657-662 (2017).
波多江 希，津田 直人，木梨 陽康，荒川 賢治.
「放線菌Streptomyces rochei の抗生物質生産を誘導するシグナル分子SRBの単離・構造決定および生合成」
第５８回天然有機化合物討論会講演要旨集, pp. 575-580 (2016).
荒川 賢治.
「放線菌のシグナル分子制御系改変による休眠二次代謝の誘導」
バイオサイエンスとインダストリー，74 [1], 40-42 (2016)
荒川 賢治.
「Streptomyces属放線菌の抗生物質生産をナノモルオーダーで誘導するシグナル分子」
化学と生物，52 [11], 712-713 (2014).
荒川賢治, 曹志生, 鈴木敏弘, 近藤寿志, 殿川亜未, 小中勇二, 板倉康浩, 鈴木夏実, 木梨陽康
「１４員環マクロライド抗生物質ランカマイシンの生合成経路」
第５３回天然有機化合物討論会講演要旨集, pp. 475-480 (2011).
荒川賢治.
「土の中に潜む放線菌生物資源の発掘」
生物工学会誌, 89 [2], 82 (2011).
荒川賢治, 木梨陽康
「線状プラスミド上の抗生物質生合成クラスターの解析とその応用」
バイオサイエンスとインダストリー, 66 [9], 504-508 (2008).
荒川賢治.
「ポリエーテル系抗生物質生合成研究の最近の進歩」
ファルマシア, 44 [5], 453-454 (2008).
荒川賢治, 児玉和也, 鈴木夏実, 井手彩洋子, 木梨陽康, 株本浩樹, 有澤章
「１４員環マクロライド抗生物質ランカマイシンのスターターユニットおよび水酸化反応の解析」
第４８回天然有機化合物討論会講演要旨集, pp. 451-456 (2006).
荒川賢治, 望月進, 杉野文規, 石井達也, 児玉和也, 木梨陽康
「ランカサイジン生合成遺伝子群の機能解析および大員環形成機構の解明」
第４６回天然有機化合物討論会講演要旨集, pp. 485-490 (2004).
荒川賢治, 茨木和也, 江口正, 柿沼勝己
「古細菌大環状脂質の合成及びその膜機能」
第４１回天然有機化合物討論会講演要旨集, pp. 115-120 (1999).
江口正, 荒川賢治, 柿沼勝己,
「30員環を越す巨大な環状化合物の合成：古細菌細胞膜の脂質分子を中心として」,
有機合成化学協会誌, 57 [9], 784-797 (1999).
江口正, 寺地拓己, 狩野弘樹, 荒川賢治, 柿沼勝己,
「古細菌大環状膜脂質の合成研究」,
第３７回天然有機化合物討論会講演要旨集, pp. 109-114 (1995).
国際会議発表
Kenji Arakawa, Naoto Tsuda, Akihiro Taniguchi, Haruyasu Kinashi
"Isolation, structural elucidation, and biosynthesis of butenolide signaling molecules that induce lankacidin and lankamycin production in Streptomyces rochei"
International Conference of Natural Products Biosynthesis (ICNPB), Awaji Shima, JAPAN (2012). (Oral)
Kenji Arakawa, Akihiro Taniguchi, Naoto Tsuda, Haruyasu Kinashi
"Isolation, structural elucidation, and biological activity of the novel gamma-butenolide signaling molecules SRBs that elicit antibiotic production in Streptomyces rochei 7434AN4"
16th International Symposium on the Biology of Actinomycetes, Puerto Vallarta, MEXICO (2011). (Poster)
Kenji Arakawa, Akihiro Taniguchi, Naoto Tsuda, Haruyasu Kinashi
"Isolation and structural elucidation of the novel gamma-butenolide signaling molecules SRBs that switch on antibiotic production in Streptomyces rochei 7434AN4”,
International Union of Microbiological Societies 2011 Congress, Sapporo, JAPAN (2011). (Oral)
Kenji Arakawa, Satoshi Tatsuno, Haruyasu Kinashi
"Biosynthesis of the 17-membered polyketide antibiotic lankacidin produced by Streptomyces rochei 7434AN4"
Pacifichem 2010 Congress, Honolulu, USA (2010). (Oral)
K. Arakawa, S. Tatsuno, H. Kinashi
"Biosynthetic study of the 17-membered polyketide antibiotic lankacidin"
The 25th Naito Conference "Chemical Biology [II]", Sapporo, JAPAN (2009).(Reviewed, Poster)
K. Arakawa, S. Tatsuno, H. Kinashi
"Biosynthesis pf the 17-membered polyketide antibiotic lankacidin"
International Symposium of Chemical Biology, Xiamen, CHINA (2009).(Oral, Invited)
K. Arakawa, S. Tatsuno, H. Kinashi
"Mutational analysis of the modular-iterative mixed polyketide biosynthesis of lankacidin"
15th International Symposium on the Biology of Actinomycetes, Shanghai, CHINA (2009).(Poster)
K. Arakawa, S. Yamamoto, Y. He, S. Mochizuki, H. Kinashi
"Regulation of lankacidin and lankamycin biosynthesis in Streptomyces rochei"
Japan-UK Workshop on Genomics of Antibiotic-producing Actinomycetes: Implications and Applications, Tokyo, JAPAN (2008). (Oral, invited)
K. Arakawa, S. Tatsuno, H. Kinashi
"A Modular-iterative Mixed Polyketide Synthases and Oxidative Macrocyclization in the Biosynthesis of the 17-Membered Antibiotic Lankacidin"
7th-Japan-US seminar, San Diego, USA (2008). (Oral, invited)
K. Arakawa, S. Tatsuno, H. Kinashi
"Analysis of modular-iterative mixed biosynthesis of lankacidin by heterologous expression and gene fusion"
14th International Symposium on the Biology of Actinomycetes, New Castle, UK (2007).(Poster)
K. Arakawa, K. Kodama, H. Kinashi
"Functions of two cytochrome P-450 hydroxylase genes involved in lankamycin biosynthesis"
Pacifichem 2005 Congress, Honolulu, USA (2005). (Poster)
K. Arakawa, S. Tatsuno, K. Kodama, F. Sugino, H. Kinashi
"Unique macrocyclization mechanism and iterative type-I PKSs involved in the lankacidin biosynthesis"
Pacifichem 2005 Congress, Honolulu, USA (2005). (Oral)
K. Arakawa, K. Kodama, H. Kinashi
"Unique macrocyclization catalyzed by amine oxidase in the lankacidin biosynthesis"
229th ACS National Meeting, San Diego, USA (2005). (Poster)
K. Arakawa, S. Mochizuki, F. Sugino, K. Kodama, S. Tatsuno, T. Ishii, H. Kinashi
"Unusual macrocyclization mechanism and iterative type-I PKSs in the lankacidin biosynthesis"
Bioorganic and Natural Product Symposium - Celebrating the 70th Birthday of Professor Heinz G. Floss, Seattle, USA (2004). (Poster)
K. Arakawa, H. Kano, T. Eguchi, K. Kakinuma
"Synthesis and Characterization of 72-Membered Macrocyclic Model, Analogues to the Membrane Lipids of Archaebacteria Growing under Extreme Environment"
7th Asian Chemical Congress, Hiroshima, Japan (1997). (Poster)
所属学会：
日本農芸化学会（中四国支部評議員2011.4-）
日本放線菌学会（理事2012.4-）
日本生物工学会（2011年バイオミディア委員）
日本化学会
アメリカ化学会
受賞歴：
2001年3月 手島記念博士論文賞受賞
2009年7月 日本放線菌学会・浜田賞
2013年3月 日本農芸化学会・農芸化学奨励賞
2015年10月 バイオインダストリー協会・発酵と代謝研究奨励賞
2016年4月 長瀬科学技術振興財団・長瀬研究振興賞
2016年11月 第15回広島大学長表彰
