List of publication (from 2005)

Ahmed Taha Ayoub, Mohamed Ali Elrefaiy, Kenji Arakawa.
“Computational prediction of the mode of binding of antitumor lankacidin C to tubulin”
ACS Omega, 4 [2], 4461-4471 (2019).

Naoya Toyoda, Tetsuya Yamamoto, Kenji Arakawa, Aiko Teshima
“Preparation of PVA / polymer colloid nanocomposite hydrogel using PS-PNVA particles”
Chemistry Letters, in press (2019).

手島 愛子, 荒川 賢治.
「微生物における共存と二次代謝生産」
生物工学会誌, 97 [3], in press (2019).

原 圭佑, 鈴木 敏弘, 荒川 賢治.
「抗生物質生合成を司るキノン補酵素要求性デヒドロゲナーゼ」
バイオサイエンスとインダストリー, 77 [2], in press(2019).

Tetsuya Yamamoto, Kenji Arakawa, Yuya Takahashi, Miho Sumiyoshi.
“Antimicrobial activities of low molecular weight polymers synthesized through soap-free emulsion polymerization”
Eur. Polym. J., 109, 532-536 (2018).

Tetsuya Yamamoto, Kenji Arakawa, Ryo Furuta, Aiko Teshima.
“Antimicrobial activities of polymers synthesized through soap-free emulsion polymerization using a cationic initiator and styrene derivative monomers”
Chemistry Letters, 47 [11], 1402-1404 (2018).

Yusuke Yamauchi, Yosi Nindita, Keisuke Hara, Asako Umeshiro, Yu Yabuuchi, Toshihiro Suzuki, Haruyasu Kinashi, Kenji Arakawa.
“Quinoprotein dehydrogenase functions at the final oxidation step of lankacidin biosynthesis in Streptomyces rochei 7434AN4”
J. Biosci. Bioeng., 126 [2], 145-152 (2018).

Kenji Arakawa.
“Manipulation of metabolic pathway controlled by signaling molecules, inducers of antibiotic production, for genome mining in Streptomyces spp.”
Antonie van Leeuwenhoek., 111 [5], 743-751 (2018).

手島 愛子, 見崎 裕也, 荒川 賢治.
「悉皆的ゲノムマイニングを指向した放線菌二次代謝生合成・誘導制御の分子基盤の統合深化」
アグリバイオ, 2 [14], pp. 49-52 (2018).

Natsumi Tsujita, Hiroyuki Kuwahara, Hiroki Koyama, Noriyuki Yanaka, Kenji Arakawa, Hisato Kuniyoshi.
"Molecular characterization of aspartylglucosaminidase, a lysosomal hydrolase upregulated during strobilation in the moon jellyfish, Aurelia aurita"
Biosci. Biotechnol. Biochem.,81 [5], 938-950 (2017).

Rikiya Kamei, Takashi Fujimura, Miki Matsuda, Kotaro Kakihara, Noriko Hirakawa, Kenji Baba, Kazuhisa Ono, Kenji Arakawa, Seiji Kawamoto.
"A flavanone derivative from the Asian medicinal herb (Perilla frutesens) potently suppresses IgE-mediated immediate hypersensitivity reactions"
Biochem. Biophys. Res. Commun. 483 [1], 674-679 (2017).

國武 博文, 岸本 拓也, 達川 綾香, 木梨 陽康, 福本 敦, 安齊 洋次郎, 荒川 賢治.
「二次代謝生合成・制御系の合目的改変により取得したアゾキシアルケン化合物KA57-Aの生合成及び生物活性」
第59回天然有機化合物討論会講演要旨集, pp.
657-662 (2017).

Ahmed Taha Ayoub, Rabab Ahmed, Jack Xiao, Cody Wayne Lewis, Tatiana Tilli, Kenji Arakawa, Yosi Nindita, Gordon Chan, Luxin Sun, Mark Glover, Mariusz Klobukowski, Jack Tuszynski.
“Antitumor activity of lankacidin antibiotics is due to microtubule stabilization via a paclitaxel-like mechanism”
J. Med. Chem., 59 [20], 9532-9540 (2016).

波多江 希,津田 直人,木梨 陽康,荒川 賢治.
放線菌Streptomyces rocheiの抗生物質生産を誘導するシグナル分子SRBの単離・構造決定および生合成
第58回天然有機化合物討論会講演要旨集, pp. 575-580 (2016).

荒川 賢治.
放線菌のシグナル分子制御系改変による休眠二次代謝の誘導
バイオサイエンスとインダストリー,74 [1] 40-42 (2016).

Hirofumi Kunitake, Takahiro Hiramatsu, Haruyasu Kinashi, Kenji Arakawa.
"Isolation and biosynthesis of an azoxyalkene compound produced by a multiple gene disruptant of Streptomyces rochei"
ChemBioChem 16 [15], 2237-2243 (2015).

Yosi Nindita, Zhisheng Cao, Yingjie Yang, Kenji Arakawa, Yuh Shiwa, Hirofumi Yoshikawa, Michihira Tagami, Alexander Lezhava, Haruyasu Kinashi.
"The tap-tpg gene pair on the linear plasmid functions to maintain a linear topology of the chromosome in Streptomyces rochei"
Mol. Microbiol.,95 [5], 846-858
(2015).

Zhisheng Cao, Ryuhei Yoshida, Haruyasu Kinashi, Kenji Arakawa.
"Chromosome circularization of the model Streptomyces species, Streptomyces coelicolor A3(2)"
J. Antibiot., 68 [5], 328-333 (2015).

荒川賢治.
Streptomyces属放線菌の抗生物質生産をナノモルオーダーで誘導するシグナル分子」
化学と生物
, 52 [11], 712-713 (2014)
.

Kenji Arakawa.
"Genetic and biochemical analysis of the antibiotic biosynthetic gene clusters on the Streptomyces linear plasmid"
Biosci. Biotechnol. Biochem., 78 [2], 183-189 (2014).

Yosi Nindita, Tomoya Nishikawa, Kenji Arakawa, Guojun Wang, Kozo Ochi, Zhongiun Qin, Haruyasu Kinashi.
"Chromosome circularization of the model Streptomyces species, Streptomyces coelicolor A3(2)"
FEMS Microbiol. Lett., 347 [2], 149-155 (2013).

Kenji Arakawa.
"Biosynthesis: Diversity between PKS and FAS"
Nat. Chem. Biol., 8 [7], 604-605 (2012).

Hisato Kuniyoshi, Izumi Okumura, Rie Kuroda, Natsumi Tsujita, Kenji Arakawa, Jun Shoji, Tamio Saito, Hiroyuki Osada.
"Indomethacin induction of metamorphosis from the asexual stage to sexual stage in the moon jellyfish, Aurelia aurita"
Biosci. Biotechnol. Biochem., 76 [7], 1397-1400 (2012).

Kenji Arakawa, Naoto Tsuda, Akihiro Taniguchi, Haruyasu Kinashi.
"The butenolide signaling molecules SRB1 and SRB2 induce lankacidin and lankamycin production in Streptomyces rochei"
ChemBioChem, 13 [10], 1447-1457 (2012).

Zhisheng Cao, Gholam Khodakaramian, Kenji Arakawa, Haruyasu Kinashi.
"Isolation of borrelidin as a phytotoxic compound from a potato pathogenic Streptomyces strain"
Biosci. Biotechnol. Biochem., 76 [2], 353-357 (2012).

Yingjie Yang, Toru Kurokawa, Yoshifumi Takahama, Yosi Nindita, Susumu Mochizuki, Kenji Arakawa, Satoru Endo, Haruyasu Kinashi.
"pSLA2-M of Streptomyces rochei is a composite linear plasmid characterized by self-defense genes and homology with pSLA2-L"
Biosci. Biotechnol. Biochem., 75 [6], 1147-1153 (2011).

Kenji Arakawa, Zhisheng Cao, Natsumi Suzuki, Haruyasu Kinashi.
"Isolation, structural elucidation, and biosynthesis of 15-norlankamycin derivatives produced by a type-II thioesterase disruptant of Streptomyces rochei"
Tetrahedron, 67 [29], 5199-5205 (2011)
.

Matthew J. Belousoff, Tal Shapira, Anat Bashan, Ella Zimmerman, Haim Rozenberg, Kenji Arakawa, Haruyasu Kinashi, Ada Yonath.
"Crystal structure of the synergistic antibiotic pair, lankamycin and lankacidin, in complex with the large ribosomal subunit"
Proc. Natl. Acad. Sci. USA, 108 [7], 2717-2722 (2011).

Heinz G. Floss, Tin-Wein Yu, Kenji Arakawa.
"The biosynthesis of 3-amino-5-hydroxybenzoic acid (AHBA), the precursor of mC7N-units in ansamycin and mitomycin antibiotics - A review"
J. Antibiot., 64 [1], 35-44 (2011).

Toshihiro Suzuki, Susumu Mochizuki, Shouji Yamamoto, Kenji Arakawa, Haruyasu Kinashi.
"Regulation of lankamycin biosynthesis in Streptomyces rochei by two SARP genes, srrY and srrZ"
Biosci. Biotechnol. Biochem., 74 [4], 819-827 (2010).

Tamar Auerbach, Inbal Mermershtain, Chen Davidovich, Anat Bashan, Matthew Belousoff, Itai Wekselman, Ella Zimmerman, Liqun Xiong, Dorota Klepacki, Kenji Arakawa, Haruyasu Kinashi, Alexander Mankin, Ada Yonath.
"The structure of ribosome-lankacidin complex reveals ribosomal sites for synergistic antibiotics"
Proc. Natl. Acad. Sci. USA, 107 [5], 1983-1988 (2010).

Kenji Arakawa.
"Characterization of the biosynthetic gene clusters located on the Streptomyces linear plasmid"
Actinomycetol., 24 [1], 24-30 (2010).

Satoshi Tatsuno, Kenji Arakawa, Haruyasu Kinashi.
"Extensive mutational analysis of modular-iterative mixed biosynthesis of lankacidin in Streptomyces rochei"
Biosci. Biotechnol. Biochem., 73 [12], 2712-2719 (2009).

Kenji Arakawa, Toshihiro Suzuki, Haruyasu Kinashi.
"Gene disruption analysis of two glycosylation steps in lankamycin biosynthesis in Streptomyces rochei"
Actinomycetol., 22 [2], 35-41 (2008).

Shouji Yamamoto, Yuxi He, Kenji Arakawa, Haruyasu Kinashi.
"Gamma-Butyrolactone-dependent expression of the SARP gene srrY plays a central role in the regulatory cascade leading to lankacidin and lankamycin production in Streptomyces rochei"
J. Bacteriol., 190 [4], 1308-1316 (2008).

荒川賢治, 木梨陽康.
「線状プラスミド上の抗生物質生合成クラスターの解析とその応用」
バイオサイエンスとインダストリー, 66 [9], 504-508 (2008)

Satoshi Tatsuno, Kenji Arakawa, Haruyasu Kinashi.
"Analysis of modular-iterative mixed biosynthesis of lankacidin by heterologous expression and gene fusion"
J. Antibiot., 60 [11], 700-708 (2007).

Kenji Arakawa, Susumu Mochizuki, Kohei Yamada, Takenori Noma, Haruyasu Kinashi.
"Gamma-Butyrolactone autoregulator-receptor system involved in lankacidin and lankamycin production and morphological differentiation in Streptomyces rochei"
Microbiology, 153 [6], 1817-1827 (2007).

Kenji Arakawa, Kazuya Kodama, Satoshi Tatsuno, Sayoko Ide, Haruyasu Kinashi.
"Analysis of the loading and hydroxylation steps in lankamycin biosynthesis in Streptomyces rochei"
Antimicrob. Agents Chemother., 50 [6], 1946-1952 (2006).

Kenji Arakawa, Fuminori Sugino, Kazuya Kodama, Tatsuya Ishii, Haruyasu Kinashi.
"Cyclization mechanism for the synthesis of macrocyclic antibiotic lankacidin in Streptomyces rochei"
Chem. Biol., 12 [2], 249-256 (2005).

  

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