―最近の論文―
Naoya Okada, Noriaki Shimizu* (2013)
Dissection of the Beta-Globin Replication-Initiation Region Reveals Specific Requirements for Replicator Elements during Gene Amplification.
PLos ONE (IF=4.351) Volume 8, Issue 10, e77350 (全10ページ, Figure 8).
Chiemi Noguchi, Yoshio Araki, Daisuke Miki, Noriaki Shimizu* (2012)
Fusion of the Dhfr/Mtx and IR/MAR gene amplification methods produces a rapid and efficient method for stable recombinant protein production.
PLos ONE (IF=4.351), Volume 7, Issue 12, e52990 (全14ページ, Figure 9, Suppl. Fig. 1).
Yoshio Araki, Tetsuro Hamafuji, Chiemi Noguchi and Noriaki Shimizu* (2012)
Efficient Recombinant Production in Mammalian Cells Using a Novel IR/MAR Gene Amplification Method.
PLos ONE (IF=4.351), Volume 7, Issue 7, e41787 (全10ページ）.
Koh-ichi Utani, Atsushi Okamoto and Noriaki Shimizu* (2011)
Generation of Micronuclei During Interphase by Coupling between Cytoplasmic Membrane Blebbing and Nuclear Budding.
PlosONE (IF=4.351), Volume 6, Issue 11, e27233 (全12ページ）
Atsushi Okamoto, Koh-ichi Utani and Noriaki Shimizu* (2011)
DNA replication occurs in all lamina positive micronuclei, but never in lamina negative micronuclei.
Mutagenesis (IF=3.983), 27(3): 323-327.
Hiromitsu Yoshimura*, Shingo Sekine, Hisashi Adachi, Yoshikatsu Uematsu, Akiko Mitani, Nobuko Futaki, Noriaki Shimizu (2011)
High-level expression of human recombinant cyclooxygenase-1 in mammalian cells using a novel gene amplification method.
Protein Expression and Purification (IF = 1.563), vol/ 80, pp41-46.
Noriaki Shimizu* (2011)
Molecular mechanisms of the origin of micronuclei from extrachromosomal elements.
Special Issue on the Micronucleus Assay for the 25th anniversary of “Mutagenesis”
Mutagenesis (IF= 3.541) (英文 review) vol. 26, pp119-123.
Saiyu Harada, Naoki Sekiguchi, and Noriaki Shimizu* (2010)
Amplification of a plasmid bearing a mammalian replication initiation region in chromosomal and extrachromosomal contexts.
Nucleic Acids Research, (IF = 7.479), pp1−12 doi:10.1093/nar/gkq882.
Koh-ichi Utani, Yuka Kohno, Atsushi Okamoto, and Noriaki Shimizu* (2010)
Emergence of Micronuclei and Their Effects on the Fate of Cells under Replication Stress.
PlosONE (IF=4.351) Vol. 5, issue 4, e10089.
Tetsuya Hashimoto, Koichi Ogino, Ryong-Woon Shin, Tetsuyuki Kitamoto, Tetsuro Kikuchi, and Noriaki Shimizu* (2010)
Age-dependent increase in lysosome-associated membrane protein 1 and early-onset behavioral deficits in APPSL transgenic mouse model of Alzheimer's disease. Neuroscience Letters (IF=1.925), vol. 469, p273−277
清水典明. (2010)
「哺乳動物ゲノム由来の染色体外遺伝因子・・・その細胞内動態と、遺伝子増幅への寄与」
化学と生物、vol. 48, no. 6, p395-401.
Seiyu Harada, Masafumi Uchida, and Noriaki Shimizu* (2009)
Episomal High Copy Number Maintenance of Hairpin-capped DNA Bearing a Replication Initiation Region in Human Cells.
The Journal of Biological Chemistry (IF=5.328), vol. 284, no. 36, pp. 24320−24327.
Koh-ichi Utani and Noriaki Shimizu* (2009)
How transcription proceeds in a large artificial heterochromatin in human cells.
Nucleic Acids Research (IF=7.260), vol. 37, no. 2, p393-404.
Noriaki Shimizu* (2008)
Extrachromosomal double minutes and chromosomal homogeneously staining regions as probes for chromosome research.
Special Issue of Cytogenetic and Genome Research (IF= 2.402) entitled “Chromosome Structure and Function”vol. 124, pp312−326.（英文長編Review）
Noriaki Shimizu*, Naomi Misaka and Koh-ichi Utani (2007)
"
Nonselective DNA Damage Induced by a Replication Inhibitor Results in the Selective Elimination of Extrachromosomal Double Minutes From Human Cancer Cells. "
Genes, Chromosomes and Cancer (IF = 3.937), vol46, no.10, p865-874.
Koh-ichi Utani, June-ko Kawamoto and Noriaki Shimizu* (2007)
Micronuclei bearing acentric extrachromosomal chromatin are transcriptionally competent and may perturb the cancer cell phenotype.
Molecular Cancer Research (IF =5.417), vol.5, p695-704. ( 表紙写真に取り上げられました）
Noriaki Shimizu*, June-ko Kawamoto and Koh-ichi Utani (2007)
Regulation of c-myc through intranuclear localization of its RNA subspecies.
Biochemical and Biophysical Research Communications (IF = 3.000),vol. 358, p806-810.
Noriaki Shimizu, Naoyuki Hanada, Kohichi Utani and Naoki Sekiguchi
(2007)
Interconversion of Intra- and Extra-chromosomal
Sites of Gene Amplification by Modulation of Gene Expression and DNA Methylation.
Journal of Cellular Biochemistry
(IF=3.591), vol.102, p515-529. ( 表紙写真に取り上げられました）
Toshihiko Hashizume and Noriaki Shimizu (2007)
Dissection of Mammalian Replicators by a Novel
Plasmid Stability Assay.
Journal of Cellular
Biochemistry (IF=3.591), vol.101, p552-565.
Tsutomu Shimura, Megumi Toyoshima, Satish Kumar Adiga, Tatsuki Kunoh, Hideki
Nagai, Noriaki Shimizu, Masao Inoue and Ohtsura Niwa* (2006)
Suppression of replication fork progression in low dose
specific p53 dependent S-phase DNA damage checkpoint.
Oncogene
(IF=6.318), vol.25, 5921-5932.
Daniela Bosisio1, Ivan Marazzi1, Alessandra Agresti, Noriaki Shimizu,
Marco E. Bianchi and Gioacchino Natoli (2006)
"A hyper-dynamic equilibrium between promoter-bound and nucleoplasmic dimers
controls NF-kB-dependent gene activity."
The EMBO Journal (IF=10.456),
vol.25, no. 4, p798-810.
Noriaki Shimizu, Fumie Kamezaki and Shiho
Shigematsu (2005)
"Tracking of microinjected DNA in live cells reveals the intracellular
behavior and elimination of extrachromosomal genetic material."
Nucleic Acids Research
(IF=7.260), vol.33, no.19, p6296-6307.
Noriaki Shimizu, Kenta Shingaki, Yukiko
Kaneko-Sasaguri, Toshihiko Hashizume and Teru Kanda (2005)
"When, where and how the bridge breaks: Anaphase bridge breakage plays
a crucial role in gene amplification and HSR-generation."
Experimental Cell
Research (IF=3.949), Vol
302, no. 2, p 233-2433（概要）
Noriaki Shimizu and Kenta Shingaki (2004)
"Macroscopic folding and replication of the homogeneously staining region
in late S phase leads to the appearance of replication bands in mitotic chromosomes."
Journal of Cell Science
(IF=7.250), Vol. 117, no. 22, p5303-5312.（概要）
Noriaki Shimizu,
Toshihiko Hashizume, Kenta Shingaki and June-ko Kawamoto (2003)
"Amplification of plasmids containing a mammalian replication initiation
region is mediated by controllable conflict between replication and transcription."
Cancer Research
(IF = 8.649), vol.63, no.17, p5281-5290.（概要）
Noriaki Shimizu, Yuri Miura, Yu Sakamoto and Ken Tsutsui (2001)
" Plasmids with a Mammalian Replication Origin and
a Matrix Attachment Region Initiate the Event Similar to Gene Amplification."
Cancer Research (IF = 8.649), vol.61, no.19, p6987-6990.（概要）
Noriaki Shimizu, Takaya Ochi and Kazuyo Itonaga (2001)
"Replication Timing of Amplified Genetic Regions
Relates to Intranuclear Localization but not to Genetic Activity or G/R-Band."
Experimental Cell Research (IF=3.949), vol. 268, no. 2, p201-210.（概要）
Tsubasa Tanaka and Noriaki Shimizu
(2000)
"Induced detachment of acentric chromatin from mitotic
chromosomes leads to their cytoplasmic localization at G1 and the micronucleation
by lamin reorganization at S-phase."
Journal of Cell Science (IF=7.250),
vol. 113, p697-707. PubMed
（概要）
Noriaki Shimizu,
Tsutomu Shimura and Tsubasa Tanaka (2000)
"Selective Elimination of Acentric Double Minutes from Cancer Cells Through
the Extrusion of Micronuclei."
Mutation Research
(IF = 3.433), vol. 448, no. 1, p81-90. PubMed
（概要）
Noriaki Shimizu, Nobuo Itoh, Hiroyasu Utiyama
and Geoffrey M. Wahl. (1998)
"Selective Entrapment of Extrachromosomally Amplified
DNA by Nuclear Budding and Micronucleation during S-phase."
The Journal of Cell Biology
(IF = 12.023), 140, 1307 - 1320. PubMed（概要）
Nobuo Itoh and Noriaki Shimizu.
(1998)
"DNA replication-dependent Intranuclear Relocation of Double Minute Chromatin."
Journal of Cell Science (IF=7.250), Vol. 111, p3275-3285. PubMed（概要）
Noriaki Shimizu, Teru Kanda, and Geoffrey
M. Wahl. (1996)
"Selective capture of acentric fragments by micronuclei provides a rapid
method for purifying extrachromosomally amplified DNA."
Nature genetics (IF = 26.494), 12 65-71. PubMed
（概要）
Noriaki Shimizu,
Hitoshi Nakamura, Takumi Kadota, Kenji Kitajima, Tsukasa Oda, Tetsuo Hirano,
and Hiroyasu Utiyama. (1994)
"Loss of amplified c-myc genes in the spontaneously
differentiated HL-60 cells."
Cancer Research
(IF = 8.649) 54 3561-3567. PubMed
（概要）
我々の研究を紹介した英文記事