【Key phrases for IM1, IM2, and IM3】
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＜IM1: Presenting Background Information＞
＜IM1-Step1: Reference to established knowledge in the field＞
IM1-Step1a（Definition）
is a major * health problem EtoJ
ex. is a common complication of EtoJ
ex. is the most common cause of EtoJ
the second leading cause of EtoJ
leading cause of cancer-related death EtoJ
cause of death from cancer EtoJ
ex. are among the most commonly prescribed drugs EtoJ
ex. cancer is the leading cause of EtoJ
ex. infection is a major cause of EtoJ
IM1-Step1b（Characteristics）
ex. which is associated with EtoJ
ex. is responsible for more than * deaths EtoJ
ex. affects * million people worldwide EtoJ
IM1-Step1c（Previous studies）
ex. trials have shown that EtoJ
ex. studies have shown that EtoJ
ex. there has been a * increase in EtoJ
＜IM1-Step2: Reference to a gap in established knowledge＞
IM1-Step2a（Problems）
ex. remains a public health concern EtoJ
ex. mortality remains high EtoJ
ex. patients are at increased risk for EtoJ
ex. Although several studies have found EtoJ
IM1-Step2b（Possibilities）
ex. is estimated to occur in *% of
ex. it has been estimated that
observational studies have EtoJ
ex. observational studies have suggested that EtoJ
＜IM2: Reviewing Related Research＞
＜IM2-Step1: Reference to important previous research＞
IM2-Step1a（Previous studies）
ex. recent studies have reported EtoJ
ex. studies have shown that EtoJ
ex. Recent studies have reported EtoJ
ex. Several studies have shown EtoJ
has been shown to improve EtoJ
approaches have been used to EtoJ
controlled trials have been done EtoJ
IM2-Step1b（Characteristics）
has been associated with increased EtoJ
has been shown to be effective for EtoJ
ex. role in the pathogenesis of EtoJ
＜IM2-Step2: Reference to a gap in previous research＞
IM2-Step2a（Problems）
ex. little is known about EtoJ
ex. however, to our knowledge, no study EtoJ
ex. to the best of our knowledge, no EtoJ
ex. to our knowledge, there has been no EtoJ
ex. has not been determined EtoJ
ex. has never been investigated EtoJ
ex. has been limited by * lack of EtoJ
ex. studies have been limited by EtoJ
ex. data are lacking EtoJ
ex. however, few studies have examined
risk of cardiovascular disease EtoJ
ex. increase the risk of cardiovascular disease EtoJ
IM2-Step2b（Possibilities）
studies have suggested that EtoJ
ex. may be effective EtoJ
＜IM3: Presenting New Research＞
＜IM3-Step1: Reference to the purpose of the present study＞
IM3-Step1a（Purpose）
Our objective was to examine EtoJ
the aim of this study was to EtoJ
the objective of this study was to EtoJ
the purpose of this study was to EtoJ
ex. the purpose of this study was to determine EtoJ
to assess the efficacy and safety of EtoJ
we aimed to assess whether EtoJ
ex. the objective of this study was to determine EtoJ
to test the hypothesis that EtoJ
ex. the aim of this study was to examine EtoJ
To address these issues, we EtoJ
＜IM3-Step2: Reference to new findings in the present study＞
IM3-Step2a（Present study）
In this article, we present EtoJ
Here we report the results of EtoJ
＜IM3-Step3: Reference to strategies used in the present study＞
IM3-Step3a（Strategies）
we conducted a randomized EtoJ
ex. We conducted a randomized, placebo-controlled trial EtoJ
ex. We conducted a phase 1 study EtoJ
we performed a randomized EtoJ
ex. We performed a randomized, controlled trial EtoJ
we investigated the efficacy EtoJ
ex. we compared the efficacy and safety of EtoJ
ex. Therefore, we performed a randomized clinical trial EtoJ
IM3-Step3b（Hypothesis）
ex. we hypothesized that * would be associated with
we tested the hypothesis that EtoJ