広島大学大学院医歯薬保健学研究院基礎生命科学部門 生体分子機能学
研究業績
2017 2016 2015 2014 2013
 

2017

原著論文
EBioMedicine. doi: 10.1016/j.ebiom.2017.05.003.
Tenomodulin is Required for Tendon Endurance Running and Collagen I Fibril Adaptation to Mechanical Load.
Dex S, Alberton P, Willkomm L, Sollradl T, Bago S, Milz S, Shakibaei M, Ignatius A, Bloch W, Clausen-Schaumann H, Shukunami C, Schieker M, Docheva D.
Am J Sports Med. doi: 10.1177/0363546517707940.
TGF-β1 Improves Biomechanical Strength by Extracellular Matrix Accumulation Without Increasing the Number of Tenogenic Lineage Cells in a Rat Rotator Cuff Repair Model.
Arimura H, Shukunami C, Tokunaga T, Karasugi T, Okamoto N, Taniwaki T, Sakamoto H, Mizuta H, Hiraki Y.
Scientific Reports 2017; 7: 45010. doi:10.1038/srep45010
(広島大学) (京都大学)
Scleraxis is required for maturation of tissue domains for proper integration of the musculoskeletal system
Yuki Yoshimoto, Aki Takimoto, Hitomi Watanabe, Yuji Hiraki, Gen Kondoh, Chisa Shukunami


総説・出版物等
CLINICAL CALCIUM(医薬ジャーナル社) 2017年3月号 vol.27 No.3 P43(367)〜49(373)
特集 筋肉研究の最前線 腱・靱帯と骨格筋
宿南知佐

このページの先頭へ
 

2016

原著論文
Stem Cells Int. 2016:8035759. doi: 10.1155/2016/8035759
Role of MSX1 in Osteogenic Differentiation of Human Dental Pulp Stem Cells.
Goto N, Fujimoto K, Fujii S, Ida-Yonemochi H, Ohshima H, Kawamoto T, Noshiro M, Shukunami C, Kozai K, Kato Y.
Int. J. Mol. Med. 38(3), 876-884
DEC2 is a negative regulator for the proliferation and differentiation of chondrocyte lineage-committed mesenchymal stem cells.
Sasamoto T, Fujimoto K, Kanawa M, Kimura J, Takeuchi J, Harada N, Goto N, Kawamoto T, Noshiro M, Suardita K, Tanne K, Kato Y.
Biomed. Rep. 4:704-710
Rhythmic expression of DEC2 protein in vivo and in vitro.
Sato F, Muragaki Y, Kawamoto T, Fujimoto K, Kato Y, Zhang Y.
PLoS Genetics 12:e1005802, 2016. doi:10.1371/journal.pgen.1005802
(広島大学) (京都大学)
Functional investigation of a non-coding variant associated with adolescent idiopathic scoliosis in zebrafish: Elevated expression of the ladybird homeobox gene causes body axis deformation
Long Guo, Hiroshi Yamashita, Ikuyo Kou, Aki Takimoto, Makiko Meguro-Horike, Shin-ichi Horike, Tetsushi Sakuma, Shigenori Miura, Taiji Adachi, Takashi Yamamoto, Shiro Ikegawa, Yuji Hiraki, Chisa Shukunami


総説・出版物等
Keynote RA(先端医学社) vol.4 No.4 p20-25
靭帯の形成と再生
吉本由紀, 滝本 晶, 宿南知佐
Gene 1;587(1):1-17
TENOgenic MODULating INsider factor : Systematic assessment on the functions of TNMD gene.
Dex S, LinD, Shukunami C, Docheva D.
Jap. Dent. Sci. Rev. 52(4), 84-92
Molecular characterization and function of tenomodulin, a marker of tendons and ligaments that integrate musculoskeletal components.
Shukunami C, Yoshimoto Y, Takimoto A, Yamashita H, Hiraki Y.

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2015

 
原著論文
Scientific Reports 5:16455, 2015. doi: 10.1038/srep16455.
OASIS modulates hypoxia pathway activity to regulate bone angiogenesis.
Cui M, Kanemoto S, Cui X, Kaneko M, Asada R, Matsuhisa K, Tanimoto K, Yoshimoto Y, Shukunami C, Imaizumi K.
Biochem Biophys Rep. 3:175-189, 2015.
Conservation of structure and function in vertebrate c-FLIP proteins despite rapid evolutionary change.
Sakamaki K, Iwabe I, Iwata H, Imai K, Takagi C, Chiba K, Shukunami C, Tomii K, Ueno N.
Am J Sports Med. 43:2411-2422, 2015.
FGF-2 stimulates the growth of tenogenic progenitor cells to facilitate the generation of Tenomodulin-positive tenocytes in a rat rotator cuff healing model.
Tokunaga TS, Shukunami C. Okamoto, N. Okada, T. Taniwaki, T. Oka, K. Sakamoto H. Mizuta H. Hiraki Y.
Am J Hum Gen. 97:337-342, 2015. 
A functional SNP in BNC2 up-regulates BNC2 expression and increases the risk of adolescent idiopathic scoliosis.
Ogura Y, Kou I, Takahashi A, Miura S, Xu L, Takahashi Y, Kono K, Kawakami N, Uno K, Ito M, Minami S, Yonezawa I, Yanagida H, Taneichi H, Zhu Z, Tsuji T. Suzuki T, Sudo H, Kotani T, Watanabe K, Hosogane N, Okada E, Sudo A, Chiba K, Toyama Y, Imai Y, Sawasaki T, Qiu Y, Shukunami C, Kubo M, Matsumoto M, Ikegawa S.
Development 142:787-796, 2015. 
Scleraxis and osterix antagonistically regulate tensile force-responsive remodeling of the periodontal ligament and alveolar bone.
Takimoto A, Kawatsu M, Yoshimoto Y, Kawamoto T, Seiryu M, Takano-Yamamoto T, Hiraki Y, Shukunami C.
Stem Cells Dev. 24:597-609, 2015.
Loss of tenomodulin results in reduced self-renewal and augmented senescence of tendon stem/progenitor cells.
Alberton P, Dex S, Popov C, Shukunami C, Schieker M, Docheva D.
Biomed. Rep. 3(4), 566-572, 2015.
Characteristic expression of MSX1, MSX2, TBX2 and ENTPD1 in dental pulp cells.
Fujii S, Fujimoto K, Goto N, Kanawa M, Kawamoto T, Pan H, Srivatanakul P, Rakdang W, Pornprasitwech J, Saskianti T, Suardita K, Nishimura F, Kato Y.
Front. Neurol. 6:166, 2015.
DEC2-E4BP4 Heterodimer Represses the Transcriptional Enhancer Activity of the EE Element in the Per2 Promoter.
Tanoue S, Fujimoto K, Myung J, Hatanaka F, Kato Y, Takumi T.
Biomed. Res. 36(2), 89-96, 2015.
Basic helix-loop-helix transcription factor DEC1 regulates the cisplatin-induced apoptotic pathway of human esophageal cancer cells.
Seino H, Wu Y, Morohashi S, Kawamoto T, Fujimoto K, Kato Y, Takai Y, Kijima H.
Int. J. Mol. Med. 35(3), 815-820, 2015.
Involvement of c-Myc in the proliferation of MCF-7 human breast cancer cells induced by bHLH transcription factor DEC2.
Wu Y, Sato H, Suzuki T, Yoshizawa T, Morohashi S, Seino H, Kawamoto T, Fujimoto K, Kato Y, Kijima H.
The Journal of Hiroshima University Dental Society 47, 32-40, 2015.
Effects of fibronectin on spreading, proliferation, and differentiation of mesenchymal stem cells under serum-free conditions.
Veronica Sainik Ronald.


総説・出版物等
日本骨代謝学会編集 (羊土社) 骨ペディア 骨疾患・骨代謝キーワード事典 p25-29
骨の血管・神経
宿南 知・イ
日本再生医療学会監修 (メディカルトリビューン) 再生医療 用語ハンドブック p106-109
腱・靱帯細胞 (p106-107), Chondromodulin-I (p108), Tenomodulin (p108-109), Scleraxis (p109)
宿南 知佐
THE BONE vol.29 No.3 p63-68
筋と骨をつなぐ臓器:腱と筋膜(Development and integration of the musculoskeletal system)
吉本 由紀, 山下 寛, 宿南 知佐
整形・災害外科 58 巻 10号 p1373-1379
腱・靱帯形成の制御
滝本 晶, 吉本 由紀, 山下 寛, 宿南 知佐

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2014

原著論文
Journal of Cell Science 127:1875-1886, 2014.
The role of the interaction of vinculin proline-rich linker region with vinexin in sensing stiffness of the extracellular matrix
Yamashita H, Ichikawa T, Matsuyama D, Kimura Y, Ueda K, Craig S W,Harada I, Kioka N.
PLoS One 9:e94239, 2014.
The N-terminal cleavage of chondromodulin-I in growth-plate cartilage at the hypertrophic and calcified zones during bone development.
Miura S, Kondo J, Takimoto A, Sano-Takai H, Guo L, Shukunami C, Tanaka H, Hiraki Y.
J Cardio. Dev Dis. 1:163-176, 2014.
Sox9- and Scleraxis-Cre Lineage Fate Mapping in Aortic and Mitral Valve Structures.
Austin BF, Yoshimoto Y, Shukunami C, Lincoln J.
PLoS Biology 12(4), e1001839, 2014
A novel protein, CHRONO, functions as a core component of the mammalian circadian clock.
Goriki A, Hatanaka F, Myung J, Kim JK, Yoritaka T, Tanoue S, Abe T, Kiyonari H, Fujimoto K, Kato Y, Todo T, Matsubara A, Forger D, Takumi T.


総説・出版物等
Current topics in developmental biology 110, 339-372.
DEC1/STRA13/SHARP2 and DEC2/SHARP1 Coordinate Physiological Processes, Including Circadian Rhythms in Response to Environmental Stimuli.
Kato Y, Kawamoto T, Fujimoto K, Noshiro M.

このページの先頭へ

2013

原著論文
Experimental Cell Resarch 319:3128-3139, 2013. 
Pax1 acts as a negative regulator of chondrocyte maturation.
Takimoto A, Mohri H, Kokubu C, Hiraki Y, Shukunami C.
Genesis 51:275-283, 2013.
Generation and characterization of ScxCre transgenic mice.
Sugimoto Y, Takimoto A, Hiraki Y, Shukunami C.
Development 140:2280-2288, 2013. 
Scx+/Sox9+ progenitors contribute to the establishment of the junction between cartilage and tendon/ligament.
Sugimoto Y, Takimoto A, Akiyama H, Kist R, Scherer G, Nakamura T, Hiraki Y, Shukunami C.
Nature Genetics 45:676-679, 2013. 
Genetic variants in GPR126 are associated with adolescent idiopathic scoliosis.
Kou I, Takahashi Y, Johnson TA, Takahashi A, Guo L, Dai J, Qiu X, Sharma S, Takimoto A, Ogura Y, Jiang H, Yan H, Kono K, Kawakami N, Uno K, Ito M, Minami S, Yanagida H, Taneichi H, Hosono N, Tsuji T, Suzuki T, Sudo H, Kotani T, Yonezawa I, Londono D, Gordon D, Herring JA, Watanabe K, Chiba K, Kamatani N, Jiang Q, Hiraki Y, Kubo M, Toyama Y, Tsunoda T, Wise CA, Qiu Y, Shukunami C, Matsumoto M, Ikegawa S.
PLoS One 8:e60203, 2013. 
Tenomodulin expression in the periodontal ligament enhances cellular adhesion.
Komiyama Y, Ohba S, Shimohata N, Nakajima K, Hojo H, Yano F, Takato T, Docheva D, Shukunami C, Hiraki Y, Chung UI.
Journal of Biochemistry 154, 373-381, 2013.
Different circadian expression of major matrix-related genes in various types of cartilage: modulation by light-dark conditions.
Honda K K, Kawamoto T, Ueda H R, Nakashima A, Ueshima T, Yamada R G, Nishimura M, Oda R, Nakamura S, Kojima T.


総説・出版物等
Pharma. Medica. 31:43-46
腱・靭帯形成の制御メカニズム
宿南 知佐

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