{"id":63,"date":"2019-04-10T20:23:33","date_gmt":"2019-04-10T11:23:33","guid":{"rendered":"https:\/\/home.hiroshima-u.ac.jp\/~mafujii\/?page_id=63"},"modified":"2025-04-25T11:00:46","modified_gmt":"2025-04-25T02:00:46","slug":"%e7%a0%94%e7%a9%b6%e6%a5%ad%e7%b8%be","status":"publish","type":"page","link":"https:\/\/home.hiroshima-u.ac.jp\/~mafujii\/%e7%a0%94%e7%a9%b6%e6%a5%ad%e7%b8%be\/","title":{"rendered":"\u7814\u7a76\u696d\u7e3e"},"content":{"rendered":"

\u56fd\u969b\u5b66\u8853\u96d1\u8a8c<\/h4>\n
Improved detection of decreased glucose handling capacities via continuous glucose monitoring-derived indices<\/a>;\r\nH. Sugimoto, H. Hironaka, T. Nakamura, T. Yamada, H. Miura, N. Suematsu, M. Fujii, T. Hirota, K. Sakaguchi, W. Ogawa, S. Kuroda, Communications Medicine. (2025) Vol.5, 103<\/span><\/span><\/pre>\n
Characteristic growth of chemical gardens from mixtures of two salts<\/a>;\r\nY. Kubodera, Y. Xu, Y. Yamaguchi, M. Matsuo, M. Fujii, M. Kageyama, O. Steinbock, S. Nakata,\r\nPhys. Chem. Chem. Phys. (2023) Vol.25, 12974\u201312978<\/span><\/span><\/pre>\n
Methylome data derived from maternal-zygotic DNA methyltransferase 3aa-\/- zebrafish<\/a>;\r\nM. Shirai, K. Takayama, H. Takahashi,\u00a0Y. Hirose,\u00a0M. Fujii,\u00a0A. Awazu,\u00a0N. Shimoda,\u00a0Y. Kikuchi,\r\nData in Brief (2022) Vol.44, 108514<\/span><\/span><\/pre>\n
In vivo transomic analyses of glucose-responsive metabolism in skeletal muscle reveal core differences between the healthy and obese states<\/a>;\r\nT. Kokaji, M. Eto, A. Hatano, K. Yugi, K. Morita, S. Ohno, M. Fujii, K. Hironaka, Y. Ito, R. Egami, S. Uematsu, A. Terakawa, Y. Pan, H. Maehara, D. Li, Y. Bai, T. Tsuchiya, H. Ozaki, H. Inoue, H. Kubota, Y. Suzuki, A. Hirayama, T. Soga, S. Kuroda,\r\nScientific Report (2022) Vol.12, 13719<\/span><\/span><\/pre>\n
Identification of aberrant transcription termination at specific gene loci with DNA hypomethylated transcription termination sites caused by DNA methyltransferase deficiency<\/a>;\r\nM. Shirai, T. Nara, H. Takahashi, K. Takayama, Y. Chen, Y. Hirose, M. Fujii, A. Awazu, N. Shimoda, Y. Kikuchi,\r\nBiophysics and Genes & Genetic Systems (2022) 21-00092<\/span><\/span><\/pre>\n
Epigenetic-structural changes in X chromosomes promote Xic pairing during early differentiation of mouse embryonic stem cells<\/a>;\r\nT. Komoto, M. Fujii, A. Awazu,\r\nBiophysics and Physicobiology (2022) Vol.19, e190018<\/span><\/span><\/pre>\n
Mathematical model of chromosomal dynamics during DNA double strand break repair in budding yeast<\/a>;\r\nS. Nakahata, T. Komoto, M. Fujii, A. Awazu,\r\nBiophysics and Physicobiology (2022) Vol.19, e190012\r\n<\/span><\/span><\/pre>\n
Partial exogastrulation due to apical-basal polarity of F-actin distribution disruption in sea urchin embryo by omeprazole<\/a>;\r\nK. Watanabe, Y. Yasui, Y. Kurose, M. Fujii, T. Yamamoto, N. Sakamoto, A. Awazu,\r\nGenes to Cells (2022) 1-17<\/span><\/span><\/pre>\n
Self-Organization of Diverse Directional Hierarchical Networks in Simple Coupled Maps with Connection Changes<\/a>;\r\nT. Nakanishi, M. Fujii, A. Awazu,\r\nJournal of the Physical Society of Japan (2022) Vol.91, 023801<\/span><\/span><\/pre>\n
Four features of temporal patterns characterize similarity among individuals and molecules by glucose ingestion in humans<\/a>;\r\nS. Fujita, Y. Karasawa, M. Fujii, K. Hironaka, S. Uda, H. Kubota, H. Inoue, Y. Sumitomo, A. Hirayama, T. Soga, S. Kuroda,\r\nnpj Systems Biology and Applications (2022) Vol.8, 1-16\r\n<\/span><\/span><\/pre>\n
Fat Induces Glucose Metabolism in Nontransformed Liver Cells and Promotes Liver Tumorigenesis<\/a>;\r\nL. A. Broadfield, J. A. G. Duarte, R. Schmieder, D. Broekaert, K. Veys, M. Planque, K. Vriens, Y. Karasawa, F. Napolitano, S. Fujita, M. Fujii, M. Eto, B. Holvoet, R. Vangoitsenhoven, J. Fernandez-Garcia, J. van Elsen, J. Dehairs, J. Zeng, J. Dooley, R. Alba Rubio, J. van Pelt, T. G.P. Gr\u00fcnewald, A. Liston, C. Mathieu, C. M. Deroose, J. V. Swinnen, D. Lambrechts, D. D. Bernardo, S. Kuroda, K. De Bock, S. Fendt,\r\nCancer Research (2021) Vol.81, 1988<\/span><\/span><\/pre>\n
Trans-omic analysis reveals obesity-associated dysregulation of inter-organ metabolic cycles between the liver and skeletal muscle<\/a>;\r\nR. Egami, T. Kokaji, A. Hatano, K. Yugi, M. Eto, K. Morita, S. Ohno, M. Fujii, K. Hironaka, S. Uematsu, A. Terakawa, Y. Bai, Y. Pan, T. Tsuchiya, H. Ozaki, H. Inoue, S. Uda, H. Kubota, Y. Suzuki, M. Matsumoto, K. I. Nakayama, A. Hirayama, T. Soga, S. Kuroda, \r\niScience (2021) Vol.24, 102217<\/span><\/span><\/pre>\n
Transomics analysis reveals allosteric and gene regulation axes for altered hepatic glucose-responsive metabolism in obesity<\/a>;\r\nT. Kokaji, A. Hatano, Y. Ito, K. Yugi, M. Eto, K. Morita, S. Ohno, M. Fujii, K. Hironaka, R. Egami, A. Terakawa, T. Tsuchiya, H. Ozaki, H. Inoue, S. Uda, H. Kubota, Y. Suzuki, K. Ikeda, M. Arita, M. Matsumoto, K. I. Nakayama, A. Hirayama, T. Soga, S. Kuroda,\r\nScience Signaling (2020) Vol.13, eaaz1236<\/span><\/span><\/pre>\n
Spontaneous organizations of diverse network structures in coupled logistic maps with a delayed connection change<\/a>;\r\nA. Ohara, M. Fujii, A. Awazu,\r\nJournal of Physical Society of Japan (2020) Vol.89, 114801<\/span><\/span><\/pre>\n
Single-cell information analysis reveals that skeletal muscles incorporate cell-to-cell variability as information not noise<\/a>;\r\nT. Wada, K. Hironaka, M. Wataya, M. Fujii, M. Eto, S. Uda, D. Hoshino, K. Kunida, H. Inoue, H. Kubota, T. Takizawa, Y. Karasawa, H. Nakatomi, N. Saito, H. Hamaguchi, Y. Furuichi, Y. Manabe, N. L. Fujii, S. Kuroda,\r\nCell Reports<\/span> (2020) Vol. 32, 108051<\/span>\r\n<\/span><\/pre>\n
Trans-omic analysis reveals Ros-dependent pentose phosphate pathway activation after high-frequency electrical stimulation in C2C12 myotubes<\/a>;<\/span>\r\nD. Hoshino, K. Kawata, K. Kunida, A. Hatano, K. Yugi, T. Wada, M. Fujii, T. Sano, Y. Ito, Y. Furuichi, Y. Manabe, Y. Suzuki, N. L. Fujii, T. Soga, S. Kuroda,\r\niScience (2020) Vol. 23, 101558<\/pre>\n
Monitoring and mathematical modeling of mitochondrial ATP in myotubes at single-cell level reveals two distinct population with different kinetics<\/a>;<\/span>\r\nN. Matsuda, K. Hironaka, M. Fujii, T. Wada, K. Kunida, H. Inoue, M. Eto, D. Hoshino, Y. Furuichi, Y. Manabe, N. Fujii, H. Noji, H. Imamura, S. Kuroda,\r\nQuantitative Biology (2020) Vol. 8, 228-237<\/pre>\n
Ultrasensitive change in nucleosome binding by multiple phosphorylations to the intrinsically disordered region of the histone chaperone FACT<\/a>;\r\n<\/span>D. Aoki, A. Awazu, M. Fujii, J. Uewaki, M. Hashimoto, N. Tochio, T. Umehara, S. Tate,\r\nJournal of Molecular Biology (2020) Vol. 432, 4637\u20134657<\/pre>\n
Affinity of rhodopsin to raft enables the aligned oligomer formation from dimers: Coarse-grained molecular dynamics simulation of disk membranes<\/a>;\r\n<\/span>Y. Kaneshige, F. Hayashi, K. Morigaki, Y. Tanimoto, H. Yamashita, M. Fujii, A. Awazu,\r\nPLoS One (2020) Vol. 15, e0226123<\/span><\/pre>\n
Robustness against additional noise in cellular information transmission;<\/a>\r\nT. Tottori, M. Fujii, S. Kuroda,\r\nPhysical Review E<\/span> (2019) Vol. 100, 042403\r\n<\/span><\/pre>\n
Logical design of oral glucose ingestion pattern minimizing blood glucose in humans;<\/a>\r\nM. Fujii, Y. Murakami, Y. Karasawa, Y. Sumitomo, S. Fujita, M. Koyama, S. Uda, H. Kubota, H. Inoue, K. Konishi, S. Oba, S. Ishii, S. Kuroda,\r\nnpj Systems Biology and Applications<\/span> (2019) Vol. 5, 31<\/span><\/pre>\n
NMDAR-mediated Ca2+<\/sup> increase shows robust information transfer in dendritic spines<\/a>;\r\nT. Tottori, M. Fujii, S. Kuroda,\r\nBiophysical Journal<\/span> (2019) Vol. 116(9), 1748\u20131758<\/span><\/pre>\n
Reconstruction of global regulatory network from signaling to cellular functions using phosphoproteomic data<\/a>;\r\nK. Kawata, K. Yugi, A. Hatano, T. Kokaji, Y. Tomizawa, M. Fujii, S. Uda, H. Kubota, M. Matsumoto, K. I. Nakayama, S. Kuroda,\r\nGenes to Cells (2018) Vol. 24, 82\u201393<\/span><\/pre>\n
Trans-omic analysis reveals fed and fasting insulin signal across phosphoproteome, transcriptome, and metabolome<\/a>;\r\nK. Kawata, A. Hatano, K. Yugi, H. Kubota, T. Sano, M. Fujii, Y. Tomizawa, T. Kokaji, K. Y. Tanaka, S. Uda, Y. Suzuki, M. Matsumoto, K. I. Nakayama, K. Saitoh, K. Kato, A. Ueno, M. Ohishi, A. Hirayama, T. Soga, S. Kuroda,\r\niScience (2018) Vol. 7, 212<\/span><\/pre>\n
Increase in hepatic and decrease in peripheral insulin clearance characterize abnormal temporal patterns of serum insulin in diabetic subjects<\/a>;\r\nK. Ohashi, M. Fujii, S. Uda, H. Kubota, H. Komada, K. Sakaguchi, W. Ogawa, S. Kuroda,\r\nnpj Systems Biology and Applications (2018) Vol. 4, 14<\/span><\/pre>\n
System identification of signaling dependent gene expression with different time-scale data<\/a>;\r\nT. Tsuchiya, M. Fujii, N. Matsuda, K. Kunida, S. Uda, H. Kubota, K. Konishi, S. Kuroda,\r\nPLoS Computational Biology (2017) Vol. 13(12), e1005913<\/span><\/pre>\n
Small-volume effect enables robust, sensitive and efficient information transfer in the spine<\/a>;\r\nM. Fujii, K. Ohashi, Y. Karasawa, M. Hikichi, S. Kuroda,\r\nBiophysical Journal (2017) Vol. 112(4), 813<\/span><\/pre>\n
Selective control of upregulated and downregulated genes by temporal patterns and doses of insulin<\/a>;\r\nT. Sano, K. Kawata, S. Ohno, K. Yugi, H. Kakuda, H. Kubota, S. Uda, M. Fujii, K. Kunida, D. Hoshino, A. Hatano, Y. Ito, M. Sato, Y. Suzuki, S. Kuroda,\r\nScience Signaling (2016) Vol. 22(9), ra112<\/span><\/pre>\n
Laguerre filter analysis with partial least square regression reveals a priming effect of ERK and CREB on c-FOS induction<\/a>;\r\nT. Kudo, S. Uda , T. Tsuchiya, T. Wada, Y. Karasawa, M. Fujii, T. H. Saito, S. Kuroda,\r\nPLoS ONE (2016) Vol. 11(8), e0160548<\/span><\/pre>\n
Glucose homeostatic law: insulin clearance predicts the progression of glucose intolerance in humans<\/a>;\r\nK. Ohashi, H. Komada, S. Uda, H. Kubota, T. Iwaki, H. Fukuzawa, Y. Komori, M. Fujii, Y. Toyoshima, K. Sakaguchi, W. Ogawa, S. Kuroda,\r\nPLoS ONE (2015) Vol. 10(12), e0143880<\/span><\/pre>\n
Stochasticity in Ca2+<\/span><\/sup> increase in spines enables robust and sensitive information coding<\/a>;\r\nT. Komura, H. Urakubo, K. Ohashi, M. Fujii, S. Kuroda,\r\nPLoS ONE (2013) Vol. 9(6), e99040<\/span><\/pre>\n
Influences of excluded volume of molecules on signaling process on biomembrane<\/a>;\r\nM. Fujii, H. Nishimori, A. Awazu,\r\nPLoS ONE (2013) Vol. 8(5), e62218<\/span><\/pre>\n
Segregation pattern reorientation of granular mixture on horizontally oscillating tray<\/a>;\r\nM. Fujii, A. Awazu, H. Nishimori,\r\nPhysical Review E (2012) Vol. 85, 041304<\/span><\/pre>\n
Saddle-node bifurcation to jammed state for quasi-one-dimensional counter chemotactic flow<\/a>;\r\nM. Fujii, A. Awazu, H. Nishimori,\r\nPhysical Review E (2010) 8 Vol. 2, 015102(R)<\/span><\/pre>\n
Counter chemotactic flow in quasi-one-dimensional path<\/a>;\r\nM. Fujii, A. Awazu, H. Nishimori,\r\nJournal of Physical Society of Japan (20<\/span>09) Vol. 78, 073801<\/pre>\n
\u56fd\u5185\u96d1\u8a8c\u30fb\u7d00\u8981<\/h4>\n
\u4f4e\u7cd6\u8cea\u98df\u4e8b\u6cd5\u304a\u3088\u3073\u30ec\u30b8\u30b9\u30bf\u30f3\u30b9\u904b\u52d5\u304c\u8eab\u4f53\u7d44\u6210\u3068\u8840\u4e2d\u4ee3\u8b1d\u7269\u30fb\u30db\u30eb\u30e2\u30f3\u6fc3\u5ea6\u306b\u4e0e\u3048\u308b\u5f71\u97ff<\/a>;\r\n\u4f0a\u85e4 \u7fd4,\u00a0\u5510\u6ca2 \u5eb7\u6689,\u00a0\u661f\u91ce \u592a\u4f51,\u00a0\u85e4\u4e95 \u96c5\u53f2,\u00a0\u885b\u85e4 \u6a39,\u00a0\u9db4 \u7d14\u4e5f,\u00a0\u67cf\u6238 \u5343\u7d75\u5b50,\u00a0\u9ed2\u7530 \u771f\u4e5f,\r\n\u4f53\u529b\u79d1\u5b66 (2019)<\/span><\/pre>\n
\u7d30\u80de\u819c\u4e0a\u306e\u6df7\u307f\u5408\u3044\u3092\u8003\u616e\u3057\u305f\u30b7\u30b0\u30ca\u30eb\u4f1d\u9054\u7cfb\u30e2\u30c7\u30eb;\r\n\u85e4\u4e95 \u96c5\u53f2, \u7c9f\u6d25 \u6681\u7d00, \u897f\u68ee \u62d3,<\/span>\r\n\u4ea4\u901a\u6d41\u6570\u7406\u7814\u7a76\u4f1a (2011)<\/span><\/pre>\n
\u6392\u9664\u4f53\u7a4d\u52b9\u679c\u3092\u8003\u616e\u3057\u305f\u7d30\u80de\u819c\u4e0a\u30b7\u30b0\u30ca\u30eb\u4f1d\u9054\u7cfb\u30e2\u30c7\u30eb;\r\n\u85e4\u4e95 \u96c5\u53f2, \u7c9f\u6d25 \u6681\u7d00, \u897f\u68ee \u62d3,<\/span>\r\n\u4ea4\u901a\u6d41\u6570\u7406\u7814\u7a76\u4f1a (2010)<\/span><\/pre>\n
\u8d70\u5316\u6027\u3092\u8003\u616e\u3057\u305f\u8907\u6570\u8eca\u7dda\u4ea4\u901a\u6d41 -\u30af\u30e9\u30b9\u30bf\u30fc\u306e\u6210\u9577\u3068\u6d41\u91cf\u3068\u306e\u95a2\u4fc2-;\r\n\u85e4\u4e95 \u96c5\u53f2, \u7c9f\u6d25 \u6681\u7d00, \u897f\u68ee \u62d3,<\/span>\r\n\u4ea4\u901a\u6d41\u6570\u7406\u7814\u7a76\u4f1a (2009)<\/span><\/pre>\n
\u8d70\u5316\u6027\u3092\u8003\u616e\u3057\u305f\u8907\u6570\u8eca\u7dda\u4ea4\u901a\u6d41;\r\n\u85e4\u4e95 \u96c5\u53f2, \u897f\u68ee \u62d3, \u7c9f\u6d25 \u6681\u7d00,<\/span>\r\n\u4ea4\u901a\u6d41\u6570\u7406\u7814\u7a76\u4f1a (2008)<\/span><\/pre>\n
\u7dcf\u8aac<\/h4>\n
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\u8840\u7cd6\u6052\u5e38\u6027\u30b7\u30b9\u30c6\u30e0\u306e\u6570\u7406\u30e2\u30c7\u30eb\u89e3\u6790<\/a>;\r\n<\/span>\u5927\u6a4b\u3000\u90c1\u3001\u85e4\u4e95\u96c5\u53f2\u3001\u5c0f\u5ddd\u6e09\u3001\u9ed2\u7530\u771f\u4e5f\u3001\r\n\u5b9f\u9a13\u533b\u5b66\u5897\u520a\u53f7 35\u5dfb5\u53f7 pp.170\u2013173<\/span><\/pre>\n
\u795e\u7d4c\u7d30\u80de\u30b9\u30d1\u30a4\u30f3\u306b\u304a\u3051\u308b\u78ba\u7387\u7684\u306a\u5fdc\u7b54\u3068\u60c5\u5831\u30b3\u30fc\u30c7\u30a3\u30f3\u30b0<\/a>;\r\n<\/span>\u85e4\u4e95\u96c5\u53f2\u3001\u9ed2\u7530\u771f\u4e5f\u3001\r\n\u533b\u5b66\u306e\u3042\u3086\u307f 253\u5dfb12\u53f7 pp.1167-1172\r\n<\/pre>\n","protected":false},"excerpt":{"rendered":"
\u56fd\u969b\u5b66\u8853\u96d1\u8a8c Improved detection of decreased glucose handling capacities via continuous glucose monitoring-derived i … \u7d9a\u304d\u3092\u8aad\u3080 \u7814\u7a76\u696d\u7e3e<\/span> →<\/span><\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"parent":0,"menu_order":318,"comment_status":"closed","ping_status":"closed","template":"","meta":{"jetpack_post_was_ever_published":false,"footnotes":""},"class_list":["post-63","page","type-page","status-publish","hentry"],"aioseo_notices":[],"jetpack_sharing_enabled":true,"jetpack_shortlink":"https:\/\/wp.me\/PaSLRw-11","_links":{"self":[{"href":"https:\/\/home.hiroshima-u.ac.jp\/~mafujii\/wp-json\/wp\/v2\/pages\/63","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/home.hiroshima-u.ac.jp\/~mafujii\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/home.hiroshima-u.ac.jp\/~mafujii\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/home.hiroshima-u.ac.jp\/~mafujii\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/home.hiroshima-u.ac.jp\/~mafujii\/wp-json\/wp\/v2\/comments?post=63"}],"version-history":[{"count":59,"href":"https:\/\/home.hiroshima-u.ac.jp\/~mafujii\/wp-json\/wp\/v2\/pages\/63\/revisions"}],"predecessor-version":[{"id":3495,"href":"https:\/\/home.hiroshima-u.ac.jp\/~mafujii\/wp-json\/wp\/v2\/pages\/63\/revisions\/3495"}],"wp:attachment":[{"href":"https:\/\/home.hiroshima-u.ac.jp\/~mafujii\/wp-json\/wp\/v2\/media?parent=63"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}