齋藤 敦
英語論文
【2024】
Ito T, Saito A, Kamikawa Y, Nakazawa N, Imaizumi K.: AIbZIP/CREB3L4 Promotes Cell Proliferation via the SKP2-p27 Axis in Luminal Androgen Receptor Subtype Triple Negative Breast Cancer. Molecular Cancer Research, 22: 373-385, 2024. https://doi.org/10.1158/1541-7786.MCR-23-0629
Sue N, Thai LM, Saito A, Boyer CK, Fordham AM, Yan C, Davenport A, Tao J, Bensellam M, Cantley J, Shi Y-C, Stephens SB, Imaizumi K, Biden TJ.: Independent activation of CREB3L2 by glucose fills a regulatory gap in mouse β-cells by co-ordinating insulin biosynthesis with secretory granule formation. Molecular Metabolism, 79:101845, 2024.
【2023】
Saito A, Kamikawa Y, Ito T, Matsuhisa K, Kaneko M, Okamoto T, Yoshimaru T, Matsushita Y, Katagiri T, Imaizumi K.: p53-independent tumor suppression by cell cycle arrest via CREB/ATF transcription factor OASIS. Cell Reports, 42: 112479, 2023. https://doi.org/10.1016/j.celrep.2023.112479
Kamikawa Y, Wu Z, Nakazawa N, Ito T, Saito A, Imaizumi K.: Impact of cell cycle on repair of ruptured nuclear envelope and sensitivity to nuclear envelope stress in glioblastoma. Cell Death Discovery, https://doi.org/10.1038/s41420-023-01534-7, 2023.
【2022】
Kamikawa Y, Saito A, Imaizumi K: Impact of Nuclear Envelope Stress on Physiological and Pathological Processes in Central Nervous System. Neurochemical Research, 47: 2478-2487, 2022.
【2021】
Kamikawa Y, Saito A, Matsuhisa K, Kaneko M, Asada R, Horikoshi Y, Tashiro S & Imaizumi K.: OASIS/CREB3L1 is a factor that responds to nuclear envelope stress. Cell Death Discovery, 7: 152, 2021.
【2020】
Matsuhisa K, Cai L, Saito A, Sakaue F, Kamikawa Y, Fujiwara S, Asada R, Kudo Y, Imaizumi K.: Toxic effects of endoplasmic reticulum stress transducer BBF2H7-derived small peptide fragments on neuronal cells. Brain Research, 1749: 147139, 2020.
Okamoto T, Wu Y, Matsuhisa K, Saito A, Sakaue F, Imaizumi K, and Kaneko M.: Hypertonicity-responsive ubiquitin ligase RNF183 promotes Na, K-ATPase lysosomal degradation through ubiquitination of its beta1 subunit. Biochemical and Biophysical Research Communications, 521: 1030-1035, 2020.
Matsuhisa K, Saito A, Cai L, Kaneko M, Okamoto T, Sakaue F, Asada R, Urano F, Yanagida K, Okochi M, Kudo Y, Matsumoto M, Nakayama K, Imaizumi K.: Production of BBF2H7-derived small peptide fragments via endoplasmic reticulum stress-dependent regulated intramembrane proteolysis. The FASEB Journal, 34: 865-880, 2020.
【2019】
Wu Y, Kimura Y, Okamoto T, Matsuhisa K, Asada R, Saito A, Sakaue F, Imaizumi K, and Kaneko M.: Inflammatory bowel disease-associated ubiquitin ligase RNF183 promotes lysosomal degradation of DR5 and TRAIL-induced caspase activation. Scientific Reports, 9: 20301, 2019.
Maeoka Y, Okamoto T, Wu Y, Saito A, Asada R, Matsuhisa K, Terao M, Takada S, Masaki T, Imaizumi K, Kaneko M.: Renal medullary tonicity regulates RNF183 expression in the collecting ducts via NFAT5. Biochemical and Biophysical Research Communications, 514: 436-442, 2019.
Osaki Y, Matsuhisa K, Che W, Kaneko M, Asada R, Masaki T, Imaizumi K, Saito A.: Calnexin promotes the folding of mutant iduronate 2-sulfatase related to mucopolysaccharidosis type II. Biochemical and Biophysical Research Communications, 514: 217-223, 2019.
Maeoka Y, Wu Y, Okamoto T, Kanemoto S, Guo XP, Saito A, Asada R, Matsuhisa K, Masaki T, Imaizumi K, Kaneko M.: NFAT5 up-regulates expression of the kidney-specific ubiquitin ligase gene Rnf183 under hypertonic conditions in inner-medullary collecting duct cells. The Journal of Biological Chemistry, 294: 101-115, 2019.
【2018】
Saito A, Imaizumi K.: Unfolded Protein Response-Dependent Communication and Contact among Endoplasmic Reticulum, Mitochondria and Plasma Membrane. International Journal of Molecular Sciences, 19: 3215, 2018.
Saito A, Cai L, Matsuhisa K, Ohtake Y, Kaneko M, Kanemoto S, Asada R, Imaizumi K.: Neuronal activity-dependent local activation of dendritic unfolded protein response promotes expression of brain-derived neurotrophic factor in cell soma. Journal of Neurochemistry, 144: 35-49, 2018.
Osaki Y, Saito A, Kanemoto S, Kaneko M, Matsuhisa K, Asada R, Masaki T, Orii K, Fukao T, Tomatsu S, Imaizumi K.: Shutdown of ER-associated degradation pathway rescues functions of mutant iduronate 2-sulfatase linked to mucopolysaccharidosis type II. Cell Death & Disease, 9: 808, 2018.
Ohtake Y, Matsuhisa K, Kaneko M, Kanemoto S, Asada R, Imaizumi K, and Saito A.: Axonal Activation of the Unfolded Protein Response Promotes Axonal Regeneration Following Peripheral Nerve Injury. Neuroscience, 375: 34-48, 2018.
Wu Y, Guo XP, Kanemoto S, Maeoka Y, Saito A, Asada R, Matsuhisa K, Ohtake Y, Imaizumi K, and Kaneko M.: Sec16A, a key protein in COPII vesicle formation, regulates the stability and localization of the novel ubiquitin ligase RNF183. Plos One, 13: e0190407, 2018.
Ohtake Y, Saito A, Li S.: Diverse functions of protein tyrosine phosphatase σ in the nervous and immune systems. Experimental Neurology, 302: 196-204, 2018.
【2017】
Saito A, Imaizumi K.: The broad spectrum of signaling pathways regulated by unfolded protein response in neuronal homeostasis. Neurochemistry International, 119: 26-34, 2017.
Kaneko M, Imaizumi K, Saito A, Kanemoto S, Asada R, Matsuhisa K, Ohtake Y.: ER Stress and Disease: Toward Prevention and Treatment. Biological & Pharmaceutical Bulletin, 40: 1337-1343, 2017.
【2016】
Saito A, Cavalli V.: Signaling Over Distances. MOLECULAR & CELLULAR PROTEOMICS, 15: 382-393, 2016.
Cui X, Cui M, Asada R, Kanemoto S, Saito A, Matsuhisa K, Kaneko M, Imaizumi K.: The androgen-induced protein AIbZIP facilitates proliferation of prostate cancer cells through downregulation of p21 expression. Scientific Reports, 6: 37310, 2016.
Kanemoto S, Nitani R, Murakami T, Kaneko M, Asada R, Matsuhisa K, Saito A, Imaizumi K.: Multivesicular body formation enhancement and exosome release during endoplasmic reticulum stress. Biochemical and Biophysical Research Communications, 480: 166-172, 2016.
Matsuhisa K, Saito A, Asada R, Kanemoto S, Kaneko M, Imaizumi K.: The physiological roles of ER stress transducer BBF2H7/CREB3L2 and its potential as a target of disease therapy. Medical Research Archives, 4, 2016.
Arima Y, Shiraishi H, Saito A, Yoshimoto K, Namera A, Makita R, Murata K, Imaizumi K, Nagao M.: The sarin-like organophosphorus agent bis(isopropyl methyl)phosphonate induces ER stress in human astrocytoma cells. The Journal of Toxicological Sciences, 41: 617-625, 2016.
【2015】
Iwamoto H, Matsuhisa K, Saito A, Kanemoto S, Asada R, Hino K, Takai T, Cui M, Cui X, Kaneko M, Arihiro K, Sugiyama K, Kurisu K, Matsubara A, Imaizumi K.: Promotion of cancer cell proliferation by cleaved and secreted luminal domains of ER stress transducer BBF2H7. PLoS One, 10: e0125982, 2015.
Okada M, Ikegawa S, Morioka M, Yamashita A, Saito A, Sawai H, Murotsuki J, Ohashi H, Okamoto T, Nishimura G, Imaizumi K, Tsumaki N.: Modeling type II collagenopathy skeletal dysplasia by directed conversion and induced pluripotent stem cells. Human Molecular Genetics, 24: 299-313, 2015.
【2014】
Saito A.: Physiological functions of endoplasmic reticulum stress transducer OASIS in central nervous system. Anatomical Science International, 89: 11-20, 2014.
Saito A, Kanemoto S, Zhang Y, Asada R, Hino K, Imaizumi K.: Chondrocyte Proliferation Regulated by Secreted Luminal Domain of ER Stress Transducer BBF2H7/CREB3L2. Molecular Cell, 53: 127-139, 2014.
Hino K, Saito A, Kido M, Kanemoto S, Asada R, Takai T, Cui M, Cui X, Imaizumi K.: Master Regulator for Chondrogenesis, Sox9, Regulates Transcriptional Activation ofthe ER Stress Transducer BBF2H7/CREB3L2 in Chondrocytes. Journal of Biological Chemistry, 289: 13810-13820, 2014.
Hino K, Saito A, Asada R, Kanemoto S, Imaizumi K.: Increased Susceptibility to Dextran Sulfate Sodium-Induced Colitis in the Endoplasmic Reticulum Stress Transducer OASIS Deficient Mice. PLoS One, 9: e88048, 2014.
【2013】
Miyagi H, Kanemoto S, Saito A, Asada R, Iwamoto H, Izumi S, Kido M, Gomi F, Nishida K , Kiuchi Y, Imaizumi K.: Transcriptional Regulation of VEGFA by the Endoplasmic Reticulum Stress Transducer OASIS in ARPE-19 Cells. PLoS One, 8: e55155. 2013.
【2012】
Saito A, Kanemoto S, Kawasaki N, Asada R, Iwamoto H, Oki M, Miyagi H, Izumi S, Sanosaka T, Nakashima K, Imaizumi K.: Unfolded protein response, activated by OASIS family transcription factors, promotes astrocyte differentiation. Nature Communications, 3: 967, 2012.
Kondo S, Hino S, Saito A, Kanemoto S, Kawasaki N, Asada R, Izumi S, Iwamoto H, Oki M, Miyagi H, Kaneko M, Nomura Y, Urano F, Imaizumi K.: Activation of OASIS family, ER stress transducers, is dependent on its stabilization. Cell Death and Differentiation, 19: 1939-1949, 2012.
Izumi S, Saito A, Kanemoto S, Kawasaki N, Asada R, Iwamoto H, Oki M, Miyagi H, Ochi M, Imaizumi K.: The Endoplasmic Reticulum Stress Transducer BBF2H7 Suppresses Apoptosis by Activating the ATF5-MCL1 Pathway in Growth Plate Cartilage. Journal of Biological Chemistry, 287: 36190-36200, 2012.
Kawasaki N, Asada R, Saito A, Kanemoto S, Imaizumi K.: Obesity-induced endoplasmic reticulum stress causes chronic inflammation in adipose tissue. Scientific Reports, 2: 799, 2012.
Asada R, Saito A, Kawasaki N, Kanemoto S, Iwamoto H, Oki M, Miyagi H, Izumi S, Imaizumi K.: The endoplasmic reticulum stress transducer OASIS is involved in the terminal differentiation of goblet cells in the large intestine. Journal of Biological Chemistry, 287: 8144-8153, 2012.
【2011】
Asada R, Kanemoto S, Kondo S, Saito A, Imaizumi K.:The signaling from endoplasmic reticulum-resident bZIP transcription factors involved in diverse cellullar physiology. Journal of Biochemistry,149: 507-18, 2011.
Kondo S, Saito A, Asada R, Kanemoto S, Imaizumi K.: Physiological unfolded protein response regulated by OASIS family members, transmembrane bZIP transcription factors. IUBMB Life, 63: 233-9, 2011.
Saito A, Ochiai K, Kondo S, Tsumagari K, Murakami T, Cavener, DR, Imaizumi K.:ER stress response mediated by the PERK-eIF2α-ATF4 pathway is involved in osteoblast differentiation induced by BMP2. Journal of Biological Chemistry, 286: 4809-4818 2011.
【2010】
Hino S-I, Kondo S, Yoshinaga K, Saito A, Murakami T, Kanemoto S, Sekiya H, Chihara K, Aikawa Y, Hara H, Kudo T, Sekimoto T, Funamoto T, Chosa E, and Imaizumi K.: Regulation of ER molecular chaperone prevents bone loss in a murine model for osteoporosis. Journal of Bone and Mineral Metabolism 28: 131-138, 2010.
Sekiya H, Murakami T, Saito A, Hino S-I, Tsumagari K, Ochiai K, and Imaizumi K.: Effects of the bisphosphonate risedronate on osteopenia in OASIS-deficient mice. Journal of Bone and Mineral Metabolism 28: 384-394, 2010.
【2009】
Murakami T, Saito A, Hino S-I, Kondo S, Kanemoto S, Chihara K, Sekiya H, Tsumagari K, Ochiai K, Yoshinaga K, Saitoh M, Nishimura R, Yoneda T, Kou I, Furuichi T, Ikegawa S, Ikawa M, Okabe M, Wanaka A, and Imaizumi K.: Signalling mediated by the endoplasmic reticulum stress transducer OASIS is involved in bone formation. Nature Cell Biology 11: 1205-1211, 2009.
Saito A, Hino S-I, Murakami T, Kanemoto S, Kondo S, Saitoh M, Nishimura R, Yoneda T, Furuichi T, Ikegawa S, Ikawa M, Okabe M, and Imaizumi K.: Regulation of endoplasmic reticulum stress response by a BBF2H7-mediated Sec23a pathway is essential for chondrogenesis. Nature Cell Biology 11: 1197-1204, 2009.
Chihara K, Saito A, Murakami T, Hino S-I, Aoki Y, Sekiya H, Aikawa Y, Wanaka A, and Imaizumi K.: Increased vulnerability of hippocampal pyramidal neurons to the toxicity of kainic acid in OASIS-deficient mice. Journal of Neurochemistry 110: 956-965, 2009.(The first two authors contributed equally to this study)
Inokuchi Y, Nakajima Y, Shimazawa M, Kurita T, Kubo M, Saito A, Sajiki H, Kudo T, Aihara M, Imaizumi K, Araie M, and Hara H.: Effect of an inducer of BiP, a molecular chaperone, on endoplasmic reticulum (ER) stress-induced retinal cell death. Investigative Ophthalmology & Visual Science 50: 334-344, 2009.
【2008】
Hosoi T, Saito A, Kume A, Okuma Y, Nomura Y, and Ozawa K.: Vanadate inhibits endoplasmic reticulum stress responses. European Journal of Pharmacology 594: 44-48, 2008.(The first two authors contributed equally to this study)
【2007】
Kondo S, Saito A, Hino S-I, Murakami T, Ogata M, Kanemoto S, Nara S, Yamashita A, Yoshinaga K, Hara H, and Imaizumi K.: BBF2H7, a novel transmembrane bZIP transcription factor, is a new type of endoplasmic reticulum stress transducer. Molecular and Cellular Biology 27: 1716-1729, 2007.
Hino S-I, Kondo S, Sekiya H, Saito A, Kanemoto S, Murakami T, Chihara K, Aoki Y, Nakamori M, Takahashi MP, and Imaizumi K.: Molecular mechanisms responsible for aberrant splicing of SERCA1 in myotonic dystrophy type 1. Human Molecular Genetics 16: 2834-2843, 2007.
Murakami T, Hino S-I, Saito A, and Imaizumi K.: Endoplasmic reticulum stress response in dendrites of cultured primary neurons. Neuroscience 146: 1-8, 2007.
Saito A, Hino S-I, Murakami T, Kondo S, and Imaizumi K.: A novel ER stress transducer, OASIS, expressed in astrocytes. Antioxidants & Redox Signaling 9: 563-571, 2007.
【2006】
Ogata M, Hino S-I, Saito A, Morikawa K, Kondo S, Kanemoto S, Murakami T, Taniguchi M, Tanii I, Yoshinaga K, Shiosaka S, Hammarback JA, Urano F, and Imaizumi K.: Autophagy is activated for cell survival after endoplasmic reticulum stress. Molecular and Cellular Biology 26: 9220-9231, 2006.
Murakami T, Kondo S, Ogata M, Kanemoto S, Saito A, Wanaka A, and Imaizumi K.: Cleavage of the membrane-bound transcription factor OASIS in response to endoplasmic reticulum stress. Journal of Neurochemistry 96: 1090-1100, 2006.
【2005】
Okumura M, Kondo S, Ogata M, Kanemoto S, Murakami T, Yanagida K, Saito A, and Imaizumi K.: Candidates for tumor-specific alternative splicing. Biochemical and Biophysical Research Communications 334: 23-29, 2005.
日本語総説
齋藤敦、今泉和則: 小胞体ストレスによる炎症制御と疾患. 臨床免疫・アレルギー科 Vol.76: 607-613, 2021.
今泉和則、齋藤敦: 小胞体における動的恒常性を制御するunfolded protein response. 実験医学 Vol.37(7): 19-26, 2019.
尾﨑陽介、齋藤敦、今泉和則: 小胞体関連分解による変異タンパク質の分解と疾患の発症. CLINICAL CALCIUM Vol.28(12): 1684-1689, 2018.
齋藤敦、今泉和則: 小胞体ストレス応答を介した軟骨形成. THE BONE Vol.32(2): 191-195, 2018.
齋藤敦、今泉和則: 神経活動依存的な小胞体ストレス応答を介した樹状突起の伸長およびスパイン形成制御. Pharma Medica Vol.35(12): 96, 2017.
齋藤敦、今泉和則: 小胞体ストレス応答におけるトランスデューサーBBF2H7の小胞体内腔ドメインによる軟骨細胞の増殖の制御. ライフサイエンス新着論文レビュー http://first.lifesciencedb.jp/archives/8232, 2014.
齋藤敦、今泉和則: 骨形成における小胞体ストレスシグナル． CLINICAL CALCIUM 23(11): 21-27, 2013.
齋藤敦、浅田梨絵、岩本秀雄、泉聡太朗、金本聡自、今泉和則: 小胞体ストレスセンサーBBF2H7の小胞体内腔ドメインの新機能. Pharma Medica 31(2): 158-159, 2013.
木戸美織、齋藤敦、金本聡自、浅田梨絵、今泉和則: 軟骨細胞におけるSox9を介した小胞体ストレスセンサーBBF2H7の発現制御機構. Pharma Medica 31(2): 166, 2013.
近藤慎一、齋藤敦、金本聡自、川崎範隆、浅田梨絵、今泉和則: 小胞体ストレスセンサーOASISおよびBBF2H7の活性化機構の解析. Pharma Medica 30(1): 110, 2012.
浅田梨絵、齋藤敦、今泉和則: 小胞体ストレスセンサーOASISによる大腸粘膜杯細胞の分化制御. Pharma Medica 30(1): 111, 2012.
齋藤敦・今泉和則: 小胞体ストレス応答による骨軟骨代謝の制御. Bio Clinica 26(7): 617-621, 2011
今泉和則、村上智彦、齋藤敦: 小胞体ストレスセンサーによる骨軟骨形成制御. 実験医学 28(4): 563-567, 2010.