分子細胞情報学セミナー
◎平成28年6月7日(火) 17:00～18:30 基礎･社会医学棟2F セミナー室2
「SUMOylation, Synaptic Development and Neurodegeneration」
Prof. Paul Fraser
（Professor, Department of Medical Biophysics,
Professor, Tanz Centre for Research in Neurodegenerative Disease,
Jeno Diener Chair in Neurodegenerative Disease, University of Toronto, Canada）
【要旨】
Small ubiquitin-like modifiers (SUMO) are covalently conjugated to target proteins which modulates their subcellular localization, activity and stability. We have recently generated SUMO transgenic mouse models which display abnormal synaptic function and indicate a key role for SUMOylation in neuronal development. Our investigations have also linked SUMOylation with the amyloid plaque and tau pathology of Alzheimer disease and highlights the unique effects of the SUMO1 and SUMO2 isoforms.