研究業績

論文発表

原著

*: corresponding author

【2020】
  • Matsuhisa K, Cai L, Saito A, Sakaue F, Kamikawa Y, Fujiwara S, Asada R, Kudo Y, Imaizumi K*.: Toxic effects of endoplasmic reticulum stress transducer BBF2H7-derived small peptide fragments on neuronal cells. Brain Research, 1749: 147139, 2020.
  • Matsuhisa K, Saito A, Cai L, Kaneko M, Okamoto T, Sakaue F, Asada R, Urano F, Yanagida K, Okochi M, Kudo Y, Matsumoto M, Nakayama K, Imaizumi K*: Production of BBF2H7-derived small peptide fragments via endoplasmic reticulum stress-dependent regulated intramembrane proteolysis. The FASEB Journal, 34(1): 865-880, 2020.
  • Okamoto T, Wu Y, Matsuhisa K, Saito A, Sakaue F, Imaizumi K, and Kaneko M.: Hypertonicity-responsive ubiquitin ligase RNF183 promotes Na, K-ATPase lysosomal degradation through ubiquitination of its beta1 subunit. Biochemical and Biophysical Research Communications, 521(4): 1030-1035, 2020.
【2019】
  • Osaki Y, Matsuhisa K, Che W, Kaneko M, Asada R, Masaki T, Imaizumi K*, Saito A*: Calnexin promotes the folding of mutant iduronate 2-sulfatase related to mucopolysaccharidosis type II. Biochemical and Biophysical Research Communications, 514(1), 217-223, 2019.
  • Wu Y, Kimura Y, Okamoto T, Matsuhisa K, Asada R, Saito A, Sakaue F, Imaizumi K, and Kaneko M.: Inflammatory bowel disease-associated ubiquitin ligase RNF183 promotes lysosomal degradation of DR5 and TRAIL-induced caspase activation. Scientific Reports, 9(1): 20301, 2019.
  • Maeoka Y, Okamoto T, Wu Y, Saito A, Asada R, Matsuhisa K, Terao M, Takeda S,  Masaki T, Imaizumi K*, Kaneko M*: Renal medullary tonicity regulates RNF183 expression in the collecting ducts via NFAT5. Biochemical and Biophysical Research Communications, 514(2), 436-442, 2019.
  • Maeoka Y, Wu Y, Okamoto T, Kanemoto S, Guo XP, Saito A, Asada R, Matsuhisa K, Masaki T, Imaizumi K*, Kaneko M*: NFAT5 up-regulates expression of the kidney-specific ubiquitin ligase gene Rnf183 under hypertonic conditions in inner-medullary collecting duct cells. The Journal of Biological Chemistry, 294(1): 101-115, 2019.
【2018】
  • Saito A*, Imaizumi K.: Unfolded Protein Response-Dependent Communication and Contact among Endoplasmic Reticulum, Mitochondria and Plasma Membrane. International Journal of Molecular Sciences, 19(10): 3215, 2018.
  • Osaki Y, Saito A*, Kanemoto S, Kaneko M, Matsuhisa K, Asada R, Masaki T, Orii K, Fukao T, Tomatsu S, Imaizumi K* : Shutdown of ER-associated degradation pathway rescues functions of mutant iduronate 2-sulfatase linked to mucopolysaccharidosis type II. Cell Death and Disease, 9(8), 808, 2018.
  • Ohtake Y, Matsuhisa K, Kaneko M, Kanemoto S, Asada R, Imaizumi K*, Saito A*: Axonal Activation of the Unfolded Protein Response Promotes Axonal Regeneration Following Peripheral Nerve Injury. Neuroscience, 375:34-48, 2018.
  • Saito A*, Cai L, Matsuhisa K, Ohtake Y, Kaneko M, Kanemoto S, Asada R, Imaizumi K*: Neuronal activity-dependent local activation of dendritic unfolded protein response promotes expression of brain-derived neurotrophic factor in cell soma. Journal of Neurochemistry, 144(1), 35-49, 2018. 
  • Wu Y, Guo XP, Kanemoto S, Maeoka Y, Saito A, Asada R, Matsuhisa K, Ohtake Y, Imaizumi K*, Kaneko M*: Sec16A, a key protein in COPII vesicle formation, regulates the stability and localization of the novel ubiquitin ligase RNF183. Plos One, 13: e0190407, 2018.
  • Ohtake Y, Saito A, Li S*.: Diverse functions of protein tyrosine phosphatase σ in the nervous and immune systems. Experimental Neurology, 302: 196-204, 2018.
【2017】
  • Saito A*, Imaizumi K: The Broad Spectrum of Signaling Pathways Regulated by Unfolded Protein Response in Neuronal Homeostasis. Neurochemistry International, S0197-0186, 30300-30305, 2017. 
  • Kaneko M*, Imaizumi K, Saito A, Kanemoto S, Asada R, Matsuhisa K, Ohtake Y: ER Stress and Disease: Toward Prevention and Treatment, Biological and Pharmaceutical Bulletin, 40, 1337-1343, 2017.
【2016】
  • Matsuhisa K, Saito A*, Asada R, Kanemoto S, Kaneko M, Imaizumi K*: The physiological roles of ER stress transducer BBF2H7/CREB3L2 and its potential as a target of disease therapy. Medical Research Archives, 4(3), 2016.
  • Saito A, Cavalli V*: Signaling Over Distances. Molecular and Cellular Proteomics, 15(2): 382-393, 2016.
  • Cui X, Cui M, Asada R, Kanemoto S, Saito A, Matsuhisa K, Kaneko M, Imaizumi K*: The androgen-induced protein AIbZIP facilitates proliferation of prostate cancer cells through downregulation of p21 expression. Scientific Reports, 6: 37310, 2016.
  • Kaneko M*, Iwase I, Yamasaki Y, Takai T, Wu Y, Kanemoto S, Matsuhisa K, Asada R, Okuma Y, Watanabe T, Imaizumi K*, Nomura Y: Genome-wide identification and gene expression profiling of ubiquitin ligases for endoplasmic reticulum protein degradation. Scientific Reports, 6: 30955, 2016.
  • Arima Y, Shiraishi H, Saito A, Yoshimoto K, Namera A, Makita R, Murata K, Imaizumi K, Nagao M*: The sarin-like organophosphorus agent bis(isopropyl methyl)phosphonate induces ER stress in human astrocytoma cells. The Journal of Toxicological Sciences, 41(5):617-625,2016.
【2015】
  • Iwamoto H#, Matsuhisa K#, Saito A, Kanemoto S, Asada R, Hino K, Takai T, Cui M, Cui X, Kaneko M, Arihiro K, Sugiyama K, Kurisu K, Matsubara A, Imaizumi K*: Promotion of cancer cell proliferation by cleaved and secreted luminal domains of ER stress transducer BBF2H7. PLoS One, 10(5): e0125982, 2015. (#: contributed equally in this study)
  • Kanemoto S*, Kobayashi Y, Yamashita T, Miyamoto T, Cui M, Asada R, Cui X, Hino K, Kaneko M, Takai T, Matsuhisa K, Takahashi N, Imaizumi K*: Luman is involved in osteoclastogenesis through the regulation of DC-STAMP expression, stability and localization. Journal of Cell Science, 128(23): 4353-4365, 2015.
  • Asada R*, Kanemoto S, Matsuhisa K, Hino K, Cui M, Cui X, Kaneko M, Imaizumi K*: IRE1a-XBP1 is a novel branch in the transcriptional regulation of Ucp1 in brown adipocytes. Scientific Reports, 5: 16580, 2015.
  • Cui M, Kanemoto S, Cui X, Kaneko M, Asada R, Matsuhisa K, Tanimoto K, Yoshimoto Y, Shukunami C, Imaizumi K*: OASIS modulates hypoxia pathway activity to regulate bone angiogenesis. Scientific Reports, 5: 16455, 2015.
  • Okada M, Ikegawa S, Morioka M, Yamashita A, Saito A, Sawai H, Murotsuki J, Ohashi H, Okamoto T, Nishimura G, Imaizumi K, Tsumaki N*: Modeling type II collagenopathy skeletal dysplasia by directed conversion and induced pluripotent stem cells. Human Molecular Genetics, 24(2): 299-313, 2015.
【2014】
  • Saito A, Kanemoto S, Zhang Y, Asada R, Hino K, Imaizumi K*: Chondrocyte Proliferation Regulated by Secreted Luminal Domain of ER Stress Transducer BBF2H7/CREB3L2. Molecular Cell, 53(1): 127-139, 2014.
  • Hino K, Saito A*, Kido M, Kanemoto S, Asada R, Takai T, Cui M, Cui X, Imaizumi K*: Master Regulator for Chondrogenesis, Sox9, Regulates Transcriptional Activation of the ER Stress Transducer BBF2H7/CREB3L2 in Chondrocytes. Journal of Biological Chemistry, 289(20): 13810-13820, 2014.
  • Hino K, Saito A, Asada R, Kanemoto S, Imaizumi K*: Increased Susceptibility to Dextran Sulfate Sodium-Induced Colitis in the Endoplasmic Reticulum Stress Transducer OASIS Deficient Mice. PLoS One, 9(2): e88048, 2014.
  • Saito A*: Physiological functions of endoplasmic reticulum stress transducer OASIS in central nervous system. Anatomical Science International, 89(1): 11-20, 2014.
【2013】
  • Miyagi H, Kanemoto S, Saito A, Asada R, Iwamoto H, Izumi S, Kido M, Gomi F, Nishida K , Kiuchi Y, Imaizumi K*: Transcriptional Regulation of VEGFA by the Endoplasmic Reticulum Stress Transducer OASIS in ARPE-19 Cells. PLoS One, 8(1): e55155, 2013.
【2012】
  • Saito A, Kanemoto S, Kawasaki N, Asada R, Iwamoto H, Oki M, Miyagi H, Izumi S, Sanosaka T, Nakashima K, Imaizumi K*: Unfolded protein response, activated by OASIS family transcription factors, promotes astrocyte differentiation. Nature Communications, 3: 967, 2012.
  • Kondo S, Hino S, Saito A, Kanemoto S, Kawasaki N, Asada R, Izumi S, Iwamoto H, Oki M, Miyagi H, Kaneko M, Nomura Y, Urano F, Imaizumi K*: Activation of OASIS family, ER stress transducers, is dependent on its stabilization. Cell Death and Differentiation, 19(12): 1939-1949, 2012.
  • Izumi S, Saito A*, Kanemoto S, Kawasaki N, Asada R, Iwamoto H, Oki M, Miyagi H, Ochi M, Imaizumi K*: The Endoplasmic Reticulum Stress Transducer BBF2H7 Suppresses Apoptosis by Activating the ATF5-MCL1 Pathway in Growth Plate Cartilage. Journal of Biological Chemistry, 287(43): 36190-36200, 2012.
  • Kawasaki N, Asada R, Saito A, Kanemoto S, Imaizumi K*: Obesity-induced endoplasmic reticulum stress causes chronic inflammation in adipose tissue. Scientific Reports, 2: 799, 2012.
  • Asada R, Saito A, Kawasaki N, Kanemoto S, Iwamoto H, Oki M, Miyagi H, Izumi S, Imaizumi K*: The endoplasmic reticulum stress transducer OASIS is involved in the terminal differentiation of goblet cells in the large intestine. Journal of Biological Chemistry, 287(11): 8144-8153, 2012.
【2011】
  • Asada R, Kanemoto S, Kondo S, Saito A, Imaizumi K*: The signaling from endoplasmic reticulum-resident bZIP transcription factors involved in diverse cellullar physiology. Journal of Biochemistry, 149(5): 507-518, 2011.
  • Kondo S, Saito A, Asada R, Kanemoto S, Imaizumi K*: Physiological unfolded protein response regulated by OASIS family members, transmembrane bZIP transcription factors. IUBMB Life, 63(4): 233-239, 2011.
  • Saito A, Ochiai K, Kondo S, Tsumagari K, Murakami T, Cavener DR, Imaizumi K*: ER stress response mediated by the PERK-eIF2α-ATF4 pathway is involved in osteoblast differentiation induced by BMP2. Journal of Biological Chemistry, 286(6): 4809-4818, 2011.
【2010】
  • Hino S-I, Kondo S, Yoshinaga K, Saito A, Murakami T, Kanemoto S, Sekiya H, Chihara K, Aikawa Y, Hara H, Kudo T, Sekimoto T, Funamoto T, Chosa E, Imaizumi K*: Regulation of ER molecular chaperone prevents bone loss in a murine model for osteoporosis. Journal of Bone and Mineral Metabolism, 28(2): 131-138, 2010.
  • Sekiya H, Murakami T, Saito A, Hino S-I, Tsumagari K, Ochiai K, Imaizumi K*: Effects of the bisphosphonate risedronate on osteopenia in OASIS-deficient mice. Journal of Bone and Mineral Metabolism, 28(4): 384-394, 2010
【2009】
  • Murakami T, Saito A, Hino S-I, Kondo S, Kanemoto S, Chihara K, Sekiya H, Tsumagari K, Ochiai K, Yoshinaga K, Saitoh M, Nishimura R, Yoneda T, Kou I, Furuichi T, Ikegawa S, Ikawa M, Okabe M, Wanaka A, Imaizumi K*: Signalling mediated by the endoplasmic reticulum stress transducer OASIS is involved in bone formation. Nature Cell Biology, 11(10): 1205-1211, 2009.
  • Saito A, Hino S-I, Murakami T, Kanemoto S, Kondo S, Saitoh M, Nishimura R, Yoneda T, Furuichi T, Ikegawa S, Ikawa M, Okabe M, Imaizumi K*: Regulation of endoplasmic reticulum stress response by a BBF2H7-mediated Sec23a pathway is essential for chondrogenesis. Nature Cell Biology, 11(10): 1197-1204, 2009.
  • Chihara K#, Saito A#, Murakami T, Hino S-I, Aoki Y, Sekiya H, Aikawa Y, Wanaka A, Imaizumi K*: Increased vulnerability of hippocampal pyramidal neurons to the toxicity of kainic acid in OASIS-deficient mice. Journal of Neurochemistry, 110(3): 956-965, 2009.(# contributed equally to this study)
  • Inokuchi Y, Nakajima Y, Shimazawa M, Kurita T, Kubo M, Saito A, Sajiki H, Kudo T, Aihara M, Imaizumi K, Araie M, Hara H*: Effect of an inducer of BiP, a molecular chaperone, on endoplasmic reticulum (ER) stress-induced retinal cell death. Investigative Ophthalmology & Visual Science, 50(1): 334-344, 2009.
【2008】
  • Hosoi T#, Saito A#, Kume A, Okuma Y, Nomura Y, Ozawa K*: Vanadate inhibits endoplasmic reticulum stress responses. European Journal of Pharmacology, 594(1-3): 44-48, 2008.(#: contributed equally to this study)
【2007】
  • Kondo S*, Saito A, Hino S-I, Murakami T, Ogata M, Kanemoto S, Nara S, Yamashita A, Yoshinaga K, Hara H, Imaizumi K*: BBF2H7, a novel transmembrane bZIP transcription factor, is a new type of endoplasmic reticulum stress transducer. Molecular and Cellular Biology, 27(5): 1716-1729, 2007.
  • Hino S-I, Kondo S, Sekiya H, Saito A, Kanemoto S, Murakami T, Chihara K, Aoki Y, Nakamori M, Takahashi MP, Imaizumi K*: Molecular mechanisms responsible for aberrant splicing of SERCA1 in myotonic dystrophy type 1. Human Molecular Genetics, 16(23): 2834-2843, 2007.
  • Murakami T, Hino S-I, Saito A, Imaizumi K*: Endoplasmic reticulum stress response in dendrites of cultured primary neurons. Neuroscience, 146(1): 1-8, 2007.
  • Saito A, Hino S-I, Murakami T, Kondo S, Imaizumi K*: A novel ER stress transducer, OASIS, expressed in astrocytes. Antioxidants & Redox Signaling, 9(5): 563-571, 2007.
【2006】
  • Ogata M, Hino S-I, Saito A, Morikawa K, Kondo S, Kanemoto S, Murakami T, Taniguchi M, Tanii I, Yoshinaga K, Shiosaka S, Hammarback JA, Urano F, Imaizumi K*: Autophagy is activated for cell survival after endoplasmic reticulum stress. Molecular and Cellular Biology, 26(24): 9220-9231, 2006.
  • Murakami T, Kondo S, Ogata M, Kanemoto S, Saito A, Wanaka A, Imaizumi K*: Cleavage of the membrane-bound transcription factor OASIS in response to endoplasmic reticulum stress. Journal of Neurochemistry, 96(4): 1090-1100, 2006.
【2005】
  • Okumura M, Kondo S, Ogata M, Kanemoto S, Murakami T, Yanagida K, Saito A, Imaizumi K*: Candidates for tumor-specific alternative splicing. Biochemical and Biophysical Research Communications, 334(1): 23-29, 2005.

総説

  • 齋藤 敦、今泉和則：小胞体ストレス応答におけるトランスデューサーBBF2H7の小胞体内腔ドメインによる軟骨細胞の増殖の制御. ライフサイエンス新着論文レビュー, http://first.lifesciencedb.jp/archives/8232, 2014.
  • 齋藤 敦、今泉和則：骨形成における小胞体ストレスシグナル. CLINICAL CALCIUM, 23(11): 21-27, 2013.
  • 齋藤 敦、浅田 梨絵、岩本 秀雄、泉 聡太朗、金本 聡自、今泉 和則：小胞体ストレスセンサーBBF2H7の小胞体内腔ドメインの新機能. Pharma Medica, 31(2): 158-159, 2013.
  • 木戸 美織、齋藤 敦、金本 聡自、浅田 梨絵、今泉 和則：軟骨細胞におけるSox9を介した小胞体ストレスセンサーBBF2H7の発現制御機構. Pharma Medica, 31(2): 166, 2013.
  • 近藤 慎一、齋藤 敦、金本 聡自、川崎 範隆、浅田 梨絵、今泉 和則：小胞体ストレスセンサーOASISおよびBBF2H7の活性化機構の解析. Pharma Medica, 30(1): 110, 2012.
  • 浅田 梨絵、齋藤 敦、今泉 和則：小胞体ストレスセンサーOASISによる大腸粘膜杯細胞の分化制御. Pharma Medica, 30(1): 111, 2012.
  • 齋藤 敦、今泉 和則：小胞体ストレス応答による骨軟骨代謝の制御. Bio Clinica, 26(7): 617-621, 2011.
  • 今泉 和則、村上 智彦、齋藤 敦：小胞体ストレスセンサーによる骨軟骨形成制御. 実験医学, 28: 563-567, 2010.