List of publication (from 2005)
Francis Reuben Paul A. Padayao, Owen Brylle L. Acosta, Rosanna I. Ramos, Reyna Marie Therese S. Sanchez, Mary Hannah Rose A. Padayao, Jonie C. Yee, Kenji Arakawa, and Norman G. Quilantang*
“Bioactivity screening and chemical profiling of Halymenia durvillei fermented by indigenous seaweed-associated Bacillus species
The Microbe, 8, 100491 (2025).
Asahi Hirata†, Miho Sumiyoshi†, Hazuki Fujita, Momoko Akimoto, Mary Hannah Rose A. Padayao, Yuto Eguchi, Maki Matsuura, Miyuki Otsuka, Kuninobu Inada, Aiko Teshima, and Kenji Arakawa*.“Rare distribution of butenolide-type signaling molecules among Streptomyces strains and functional importance as inducing factors for secondary metabolite production in Streptomyces rochei 7434AN4”
The Journal of Antibiotics, 78, 488-499 (2025).
Koji Kakugawa*, Shion Uehara, Syunya Katoh, Naoki Arimatsu, Sho Ogaki, Koji Masumura, Hideki Murakawa, Kenji Arakawa, Masaki Mizunuma.
“Date, a major dried fruit, extends the lifespan of Caenorhabditis elegans”
Journal of Bioscience and Bioengineering, 140, 36-41 (2025).
Tomoki Kodama, Ayana Yokoyama, Yuki Nishioka, Riku Kawasaki, Aiko Teshima, Akira Maeda, Ayano Hojo, Takumi Suizu, Hideto Torii, Kotaro Fujioka, Shinsuke Kishida, Takashi Fujimura, Kenji Arakawa, Atsushi Ikeda, Seiji Kawamoto *.
“Fermented plant product (FPP) suppresses immediate hypersensitivity reactions with impaired high-affinity IgE receptor (FcεRI) signaling”
Cytotechnology, 77, 69 (2025).
Keigo Horiuchi, Goshi Matsushima, Momoe Wada, Mina Thon, Mohamed Hossam Sobhy, Ahmed Taha Ayoub, Misato Hara, Michiko Yoshii, Kenji Arakawa, Koichiro Ozawa*, Toru Hosoi*.
“A unique compound ameliorating endoplasmic reticulum stress and insulin resistance by binding to β tubulin”
The FASEB Journal, 38, e70150 (2024).
Awet Alem Teklemichael†, Aiko Teshima†, Asahi Hirata, Momoko Akimoto, Mayumi Taniguchi, Gholam Khodakaramian, Takashi Fujimura, Fuyuki Tokumasu, Kenji Arakawa*, and Shusaku Mizukami*.
“Discovery of antimalarial drugs from secondary metabolites in actinomycetes culture library”
Tropical Medicine and Health, 52, 47 (2024).
Rukman Muslimin†, Alimuddin Ali†, Sho Ogaki, Nurjannah, Ummu Kalsum Alam, Sisun Choi, Eung-Soo Kim, and Kenji Arakawa*.
“Detection of seco-macrotetrolides caused by regiospecific hydrolysis in Indonesian Streptomyces strains isolated at the karst area in Sulawesi Island7434AN4”
Tetrahedron
160, 134045 (2024).
Yu Tanaka†, Haruka Nagano†, Mei Okano, Takuya Kishimoto, Ayaka Tatsukawa, Hirofumi Kunitake, Atsushi Fukumoto, Yojiro Anzai, and Kenji Arakawa*.
“Isolation of hydrazide-alkenes with different amino-acid origins from an azoxy-alkene-producing mutant of Streptomyces rochei 7434AN4”
Journal of Natural Products, 86, 2185-2192 (2023).
Yuya Misaki, Tomomi Hirashima, Karin Fujii, Asahi Hirata, Yutaro Hoshino, Miho Sumiyoshi, Sachiko Masaki, Toshihiro Suzuki, Kuninobu Inada, Hiroki Koyama, Hisato Kuniyoshi*, and Kenji Arakawa*.
“4-Methoxy-2,2’-bipyrrole-5-carbaldehyde, a biosynthetic intermediate of bipyrrole-containing natural products from the Streptomyces culture, arrests the strobilation of moon jellyfish Aurelia coerulea”
Frontiers in Marine Science,10, 1198136 (2023).
Mingge Zhang, Bao Shuang, and Kenji Arakawa*.
“New lankamycin derivative with a branched-chain sugar from a blocked mutant of chalcose
biosynthesis in Streptomyces rochei 7434AN4”
Bioorg. Med. Chem. Lett., 80, 129125 (2023).
Islam A.T.M. Rafuqul, Keita Shinzato, Hiroki Miyaoka, Kenji Komaguchi, Kanae Koike, Kenji Arakawa, Kenji Kitamura, Nobukazu Tanaka*.
”Isolation and characterization of blackish-brown BY2-melanin accumulated in cultured tobacco
BY-2 cells”
Biosci. Biotechnol. Biochem., 87, 395-410 (2023).
Aoi Takeuchi, Asahi Hirata, Aiko Teshima, Miu Ueki, Takumi Satoh, Kenichi, Matsuda, Toshiyuki Wakimoto, Kenji Arakawa, Morio Ishikawa, and Toshihiro Suzuki*.
“Characterization of the surugamide biosynthetic gene cluster of TUA-NUK25, a Streptomyces diastaticus strain isolated from Kusaya and its effects on salt-dependent growth”
Biosci. Biotechnol. Biochem., 87, 320-329 (2023).
Ahmed Taha Ayoub, Natsumi Nishiura, Aiko Teshima, Mohamed Ali Elrefaiy, Rukman Muslimin, Kiep Minh Do, Takeshi Kodama, Cody Wayne Lewis, Gordon Chan, Hiroyuki Morita, and Kenji Arakawa*.
“Bio-inspored computational design of lankacidin derivatives for the improvement of antitumor activity”
Future Medicinal Chemistry, 14, 1349-1360 (2022).
Ayaka Tatsukawa, Yu Tanaka, Haruka Nagano, Atsushi Fukumoto, Yojiro Anzai, and Kenji Arakawa*.
“Isolation, biosynthetic investigation, and biological evaluation of maniwamycin G, an azoxyalkene compound from Streptomyces sp. TOHO-M025”
Journal of Natural Products, 85, 1867-1871 (2022).
Yuya Misaki, Yuzuru Takahashi, Keisuke Hara, Satoshi Tatsuno, and Kenji Arakawa*.
“Three 4-monosubstituted butyrolactones from a regulatory gene mutant of Streptomyces rochei 7434AN4”
J. Biosci. Bioeng.,133, 329-334 (2022).
Kenji Arakawa* and Toshihiro Suzuki.
“Regulation of secondary metabolites through signaling molecules in Streptomyces”
in Natural Products from Actinomycetes – Diversity, Ecology and Drug Discovery -, Eds Ravishankar V. Rai and Jamuna A. Bai, pp. 167-184, Springer Nature (2022).
Kazuya Yamanaka*, Hibiki Fukumoto, Naoki Yoshimura, Kenji Arakawa, Yasuo Kato, Yoshimitsu Hamano, and Tadao Oikawa.
“Discovery of a poly-amino acid antibiotic solely comprising of L-beta-lysine by potential producer prioritization-guided genome mining”
ACS Chemical Biology, 17, 171-180 (2022).
Rukman Muslimin, Natsumi Nishiura, Aiko Teshima, Kiep Minh Do, Takeshi Kodama, Hiroyuki Morita, Cody Wayne Lewis, Gordon Chan, Ahmed Taha Ayoub, and Kenji Arakawa*.
“Chemoenzymatic synthesis, computational investigation, and antitumor activity of monocyclic lankacidin derivatives”
Bioorganic & Medicinal Chemistry, 53, 116551 (2022).
Yuya Misaki, Yosi Nindita, Kota Fujita, Amirudin Akhmad Fauzi, Kenji Arakawa*.
“Overexpression of SRO_3163, a homolog of Streptomyces antibiotic regulatory protein, induces the production of novel cyclohexene-containing enamide in Streptomyces rochei”
Biosci. Biotechnol. Biochem., 86, 177-184 (2022).
Aiko Tanaka, Maarten H. Ryder, Takamasa Suzuki, Kazuma Uesaka, Nobuo Yamaguchi, Tomoko Amimoto, Motoyasu Otani, Osamu Nakayachi, Kenji Arakawa, Nobukazu Tanaka, and Daigo Takemoto*.
“Production of agrocinopine A by Ipomoea batatas agrocinopine synthase in transgenic tobacco and its effect on the rhizosphere microbial community”
Molecular Plant-Microbe Interactions, 35, 73-84 (2022).
Aiko Teshima, Hisashi Kondo, Yu Tanaka, Yosi Nindita, Yuya Misaki, Yuji Konaka, Yasuhuri Itakura, Tsugumi Tonokawa, Haruyasu Kinashi, and Kenji Arakawa*.
“Substrate specificity of two cytochrome P450 monooxygenases involved in lankamycin biosynthesis”
Biosci. Biotechnol.
Biochem., 85, 115-125 (2021).
Aiko Teshima, Nozomi Hadae, Naoto Tsuda, and Kenji Arakawa*.
“Functional analysis of P450 monooxygenase
SrrO in the biosynthesis of butenolide-type signaling molecules in Streptomyces rochei”
Biomolecules, 10, 1237 (2020).
Yuya Misaki, Shouji Yamamoto, Toshihiro Suzuki, Miyuki Iwakuni, Hiroaki Sasaki, Yuzuru Takahashi,
Kuninobu Inada, Haruyasu Kinashi, and Kenji Arakawa.*
“SrrB, a pseudo-receptor protein, acts as a negative regulator for lankacidin
and lankamycin production in Streptomyces rochei”
Tetsuya Yamamoto*, Ryo Furuta, Kenji Arakawa, Aiko Teshima.
“Relationship
between dispersion-forming capability of poly(4-vinylaniline) colloids and
antimicrobial activity”
Colloids and Surfaces A: Physicochemical and
Engineering Aspects, 596, 124736 (2020).
Tetsuya Yamamoto*, Kenji Arakawa, Ryo Furuta, Aiko Teshima.
“Influence of the morphology and size of
polystyrene synthesized through soap-free emulsion polymerization on
antimicrobial activity”
Materials Today Communications, 20, 100572 (2019).
Yosi Nindita, Zhisheng Cao, Amirudin Akhmad Fauzi, Aiko Teshima, Yuya Misaki,
Rukman Muslimin, Yingjie Yang, Yuh Shiwa, Hirofumi Yoshikawa, Michihira
Tagami, Alexander Lezhava, Jun Ishikawa, Makoto Kuroda, Tsuyoshi Sekizuka,
Kuninobu Inada, Haruyasu Kinashi, and Kenji Arakawa.*
“The genome sequence of Streptomyces rochei 7434AN4, which carries a
linear chromosome and three characteristic linear plasmids”
Scientific Reports, 9, 10973 (2019).
Ahmed Taha Ayoub, Mohamed Ali Elrefaiy, Kenji Arakawa.
“Computational prediction of the mode of binding
of antitumor lankacidin C to tubulin”
ACS
Omega, 4, 4461-4471 (2019).
Naoya Toyoda, Tetsuya Yamamoto, Kenji Arakawa, Aiko Teshima.
“Preparation of PVA/polymer colloid nanocomposite hydrogel using PS-PNVA
particles”
Chem. Lett., 48, 378-381 (2019).
Tetsuya
Yamamoto, Kenji Arakawa, Yuya Takahashi, Miho Sumiyoshi.
“Antimicrobial
activities of low molecular weight polymers synthesized through soap-free
emulsion polymerization”
Eur. Polym. J., 109, 532-536 (2018).
Tetsuya
Yamamoto, Kenji Arakawa, Ryo Furuta, Aiko Teshima.
“Antimicrobial
activities of polymers synthesized through soap-free emulsion polymerization
using a cationic initiator and styrene derivative monomers”
Chem. Lett., 47, 1402-1404 (2018). DOI: 10.1246/cl.180762
Yusuke Yamauchi, Yosi Nindita, Keisuke Hara, Asako Umeshiro, Yu Yabuuchi,
Toshihiro Suzuki, Haruyasu Kinashi, Kenji Arakawa.
“Quinoprotein dehydrogenase functions at the final oxidation step of lankacidin
biosynthesis in Streptomyces rochei 7434AN4”
J. Biosci. Bioeng., 126, 145-152 (2018).
Kenji Arakawa.
“Manipulation of
metabolic pathway controlled by signaling molecules, inducers of antibiotic
production, for genome mining in Streptomyces
spp.”
Antonie van Leeuwenhoek., 111, 743-751 (2018).
Natsumi Tsujita, Hiroyuki Kuwahara, Hiroki Koyama, Noriyuki Yanaka, Kenji Arakawa, Hisato
Kuniyoshi.
“Molecular characterization of aspartylglucosaminidase, a lysosomal
hydrolase upregulated during strobilation in the moon jellyfish, Aurelia aurita”
Biosci. Biotechnol.
Biochem., 81, 938-950 (2017).
Rikiya Kamei, Takashi Fujimura, Miki Matsuda, Kotaro Kakihara, Noriko Hirakawa,
Kenji Baba, Kazuhisa Ono, Kenji Arakawa, Seiji Kawamoto.
“A flavanone derivative from the Asian medicinal herb (Perilla
frutescens) potently suppresses
IgE-mediated immediate hypersensitivity reactions”
Biochem.
Biophys. Res. Commun., 483, 674-679 (2017).
Ahmed Taha Ayoub, Rabab M. Abou El-Magd, Jack Xiao, Cody Wayne Lewis, Tatiana Martins Tilli,
Kenji Arakawa, Yosi Nindita, Gordon Chan, Luxin Sun, Mark Glover, Mariusz
Klobukowski, Jack Tuszynski.
“Antitumor activity of lankacidin antibiotics is due to microtubule
stabilization via a paclitaxel-like mechanism”
J. Med. Chem., 59, 9532-9540 (2016).
Hirofumi Kunitake, Takahiro Hiramatsu, Haruyasu Kinashi, Kenji Arakawa.
“Isolation and biosynthesis of an azoxyalkene compound produced by a multiple
gene disruptant of Streptomyces rochei”
ChemBioChem,16, 2237-2243 (2015).
Yosi Nindita, Zhisheng Cao, Yingjie Yang, Kenji Arakawa, Yuh Shiwa, Hirofumi
Yoshikawa, Michihira Tagami, Alexander Lezhava, Haruyasu Kinashi.
“The tap-tpg gene pair on the linear plasmid functions to maintain a linear topology
of the chromosome in Streptomyces rochei”
Mol. Microbiol., 95, 846-858 (2015).
Zhisheng Cao, Ryuhei Yoshida, Haruyasu Kinashi, Kenji Arakawa.
“Blockage of the early step of lankacidin biosynthesis caused a large
production of pentamycin, citreodiol, and epi-citreodiol in Streptomyces rochei”
J. Antibiot., 68, 328-333 (2015).
Kenji Arakawa.
“Genetic and
biochemical analysis of the antibiotic biosynthetic gene clusters on the Streptomyces linear plasmid”
Biosci. Biotechnol. Biochem., 78, 183-189 (2014).
Yosi Nindita, Tomoya Nishikawa, Kenji Arakawa, Guojun Wang, Kozo Ochi,
Zhongjun Qin, Haruyasu Kinashi.
“Chromosome circularization of the model Streptomyces species, Streptomycescoelicolor A3(2)”
FEMS Microbiol. Lett., 347, 149-155 (2013).
Hisato Kuniyoshi, Izumi Okumura, Rie Kuroda, Kenji Arakawa, Jun Shoji, Tamio Saito, Hiroyuki
Osada.
“Indomethacin induces transition from asexual stage to sexual state in the
moon jellyfish, Aurelia aurita”
Biosci. Biotechnol. Biochem., 76, 1397-1400 (2012).
Kenji Arakawa, Naoto Tsuda, Akihiro Taniguchi, Haruyasu Kinashi.
“The butenolide signaling molecules SRB1 and SRB2 induce lankacidin and
lankamycin production in Streptomycesrochei”
ChemBioChem,13, 1447-1457 (2012).
Zhisheng Cao, Gholam Khodakaramian, Kenji Arakawa, Haruyasu Kinashi.
“Isolation of borrelidin as a phytotoxic compound from a potato pathogenic
Streptomyces strain”
Biosci. Biotechnol. Biochem., 76, 353-357 (2012).
Kenji Arakawa.
“Diversity
between PKS and FAS”
Nature
Chem. Biol., 8, 604-605 (2012).
Yingjie Yang, Toru Kurokawa, Yoshifumi Takahama, Yosi Nindita, Susumu Mochizuki,
Kenji Arakawa, Satoru Endo, Haruyasu Kinashi.
“pSLA2-M of Streptomycesrochei is a composite linear
plasmid characterized by self-defense genes and homology with pSLA2-L”
Biosci.
Biotechnol. Biochem., 75, 1147-1153 (2011).
Kenji Arakawa, Zhisheng Cao,
Natsumi Suzuki, Haruyasu Kinashi.
“Isolation, structural elucidation, and biosynthesis of 15-norlankamycin
derivatives produced by a type-II thioesterase disruptant of Streptomycesrochei”
Tetrahedron, 67, 5199-5205 (2011).
Matthew J. Belousoff, Tal Shapira, Anat Bashan, Ella Zimmerman, Haim Rozenberg,
Kenji Arakawa, Haruyasu Kinashi, Ada Yonath.
“Crystal structure of the synergistic antibiotic pair, lankamycin and
lankacidin, in complex with the large ribosomal subunit”,
Proc. Natl. Acad. Sci. USA, 108, 2717-2722 (2011).
Heinz G. Floss*, Tin-Wein Yu, Kenji Arakawa
“The biosynthesis
of 3-amino-5-hydroxybenzoic acid (AHBA), the precursor of mC7N-units
in ansamycin and mitomycin antibiotics - A review”
J.
Antibiot., 64, 35-44 (2011).
Toshihiro Suzuki, Susumu Mochizuki, Shouji Yamamoto, Kenji Arakawa, Haruyasu
Kinashi.
“Regulation of lankamycin biosynthesis in Streptomyces rochei by
two SARP genes, srrY and srrZ”
Biosci. Biotechnol. Biochem., 74, 819-827 (2010).
Kenji Arakawa.
“Characterization
of the biosynthetic gene clusters located on the Streptomyces linear plasmid”
Actinomycetol., 24, 24-30 (2010).
Tamar Auerbach, Inbal Mermershtain, Chen Davidovich, Anat Bashan, Matthew
Belousoff, Itai Wekselman, Ella Zimmerman, Liqun Xiong, Dorota Klepacki,
Kenji Arakawa, Haruyasu Kinashi, Alexander Mankin, Ada Yonath.
“The structure of ribosome-lankacidin complex reveals ribosomal sites for
synergistic antibiotics”
Proc. Natl. Acad. Sci. USA, 107, 1983-1988 (2010).
Satoshi Tatsuno, Kenji Arakawa, Haruyasu Kinashi.
“Extensive mutational analysis of modular-iterative mixed polyketide biosynthesis
of lankacidin in Streptomycesrochei”
Biosci. Biotechnol. Biochem., 73, 2712-2719 (2009).
Kenji Arakawa, Toshihiro Suzuki, Haruyasu Kinashi.
“Gene disruption analysis of two glycosylation steps in lankamycin biosynthesis
in Streptomycesrochei”
Actinomycetol., 22, 35-41 (2008).
Shouji Yamamoto, Yuxi He, Kenji Arakawa, Haruyasu Kinashi.
“Gamma-Butyrolactone-dependent expression of the SARP gene srrY plays a
central role in the regulatory cascade leading to lankacidin and lankamycin
production in Streptomyces rochei”
J. Bacteriol., 190, 1308-1316 (2008).
Satoshi Tatsuno, Kenji Arakawa, Haruyasu Kinashi.
“Analysis of modular-iterative mixed biosynthesis of lankacidin by heterologous
expression and gene fusion”
J. Antibiot., 60, 700-708 (2007).
Kenji Arakawa, Susumu
Mochizuki, Kohei Yamada, Takenori Noma, Haruyasu Kinashi.
”Gamma-Butyrolactone
autoregulator-receptor system involved in lankacidin and lankamycin production
and morphological differentiation in Streptomyces rochei”
Microbiology, 153, 1817-1827 (2007).
Kenji Arakawa, Kazuya Kodama, Satoshi Tatsuno, Sayoko Ide, Haruyasu Kinashi.
"Analysis of the loading and hydroxylation
steps in lankamycin biosynthesis in Streptomyces rochei”
Antimicrob. Agents Chemother., 50, 1946-1952 (2006).
Kenji Arakawa, Fuminori Sugino, Kazuya Kodama, Tatsuya Ishii, Haruyasu Kinashi.
"Cyclization mechanism for the synthesis of
macrocyclic antibiotic lankacidin in Streptomyces rochei"
Chem. Biol., 12, 249-256 (2005).
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